4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions

Cite

Lin, J.P., Brake, A., Donadieu, M., Lee, A., Smith, G., Hu, K., Nair, G., Kawaguchi, R., Sati, P., Geschwind, D.H. and Jacobson, S., 2025. 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions. Science, 387(6737), p.eadp6325. https://doi.org/10.1126/science.adp6325

Abstract

Inferring cellular and molecular dynamics of multiple sclerosis (MS) lesions from postmortem tissue collected decades after onset is challenging. Using magnetic resonance image (MRI)–guided spatiotemporal RNA profiling in marmoset experimental autoimmune encephalitis (EAE), we mapped lesion dynamics and modeled molecular perturbations relevant to MS. Five distinct lesion microenvironments emerged, involving neuroglial responses, tissue destruction and repair, and brain border regulation. Before demyelination, MRI identified a high ratio of proton density–weighted signal to T1 relaxation time, capturing early hypercellularity, and elevated astrocytic and ependymal senescence signals marked perivascular and periventricular areas that later became demyelination hotspots. As lesions expanded, concentric glial barriers formed, initially dominated by proliferating and diversifying microglia and oligodendrocyte precursors, later replaced by monocytes and lymphocytes. We highlight SERPINE1+ astrocytes as a signaling hub underlying lesion onset in both marmoset EAE and MS.

Datasets

1. All cells

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

Sequencing platform

Batch ID

LMin days

LMax days

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Leiden clustering

Cell type

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v3.4.621,674 cells

v3.9.521,368 cells

v3.8.520,802 cells

v3.7.820,776 cells

v3.8.320,749 cells

v3.8.720,261 cells

v3.3.420,235 cells

v3.7.620,213 cells

v3.9.719,162 cells

v3.7.718,528 cells

v3.6.818,411 cells

v3.4.518,192 cells

v3.7.418,137 cells

v3.7.317,763 cells

v3.9.217,243 cells

v3.7.216,542 cells

v3.3.116,400 cells

v3.6.415,899 cells

v3.6.715,686 cells

v3.7.115,194 cells

v3.6.314,663 cells

v3.8.414,529 cells

v3.8.114,440 cells

v3.3.713,284 cells

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v3.7.511,521 cells

v3.6.611,366 cells

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v3.9.611,234 cells

v3.3.310,497 cells

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v3.6.26,513 cells

v3.9.86,018 cells

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v3.9.45,256 cells

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v3.1.32,533 cells

v3.1.22,363 cells

v3.1.11,578 cells

CJM07109,559 cells

CJH09102,713 cells

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CJR0286,397 cells

CJH0176,242 cells

CJP0351,415 cells

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CJR0529,634 cells

F479,439 cells

M116,031 cells

4102 days109,559 cells

2810 days102,713 cells

2670 days102,032 cells

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04aCC5,220 cells

WM458,821 cells

GM90,762 cells

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LGN45,887 cells

pCC45,463 cells

aCC5,220 cells

SS08.L.A76,864 cells

SS06.R.B54,685 cells

SS08.R.C45,341 cells

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SS05.L.C36,983 cells

SS06.L.A36,189 cells

SS06.L.B28,969 cells

SS07.L26,759 cells

SS08.L.C24,180 cells

SS05.R.A20,776 cells

SS07.L.A18,704 cells

SS08.L.B18,518 cells

SS05.L18,260 cells

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SS03.L14,833 cells

SS03.L.C13,644 cells

SS08.L13,621 cells

SS06.R.C11,335 cells

SS06.L10,320 cells

SS06.R7,928 cells

SS08.R.A7,620 cells

SS03.R6,157 cells

SS03.R.B1,747 cells

SS03.R.A1,427 cells

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He.Control162,639 cells

NA.Control53,926 cells

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<45D297,856 cells

0D216,565 cells

>1000D81,049 cells

0_0121,883 cells

0~094,682 cells

7~4148,540 cells

10~2229,235 cells

0_1927,508 cells

0~727,296 cells

0~1926,459 cells

7_4114,868 cells

10~2313,782 cells

0~1012,760 cells

0~2012,739 cells

10_2212,199 cells

0~2111,544 cells

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0_711,328 cells

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0~979,009 cells

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0_218,717 cells

0_978,234 cells

0_208,063 cells

0_107,989 cells

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1369_13836,599 cells

1348~13694,996 cells

1369~13834,635 cells

1274_13484,588 cells

1335~13484,557 cells

1239~12744,086 cells

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Ctrl162,639 cells

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He.Control_0D162,639 cells

NA.Control_0D53,926 cells

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T2.Lesion_>1000D35,015 cells

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WM_<45D239,498 cells

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tWM_Re.Lesion41,446 cells

pCTX_He.Control39,866 cells

pCTX_T2.Lesion31,734 cells

pWM_He.Control30,116 cells

pCC_He.Control27,052 cells

LGN_Ab.Tissue26,624 cells

tWM_He.Control24,480 cells

tWM_Gd.Lesion20,802 cells

tWM_T2.Lesion20,749 cells

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pWM_NA.Control20,235 cells

LGN_He.Control19,263 cells

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tWM_NA.Control14,529 cells

OpT_He.Control12,531 cells

aCC_He.Control5,220 cells

pWM_Re.Lesion4,588 cells

fWM_He.Control4,111 cells

NovaS2586,139 cells

Hi40009,331 cells

7th138,674 cells

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6th94,688 cells

3rd85,336 cells

9th80,281 cells

4th39,866 cells

2nd19,263 cells

1st9,331 cells

0.0388,211 cells

7.063,408 cells

10.062,802 cells

1348.016,400 cells

1274.015,194 cells

1239.014,440 cells

1335.013,284 cells

1369.011,234 cells

1447.010,497 cells

0.0216,565 cells

41.063,408 cells

19.053,967 cells

22.041,434 cells

7.038,624 cells

1348.028,478 cells

23.021,368 cells

20.020,802 cells

10.020,749 cells

21.020,261 cells

97.017,243 cells

1369.016,400 cells

1274.014,440 cells

1383.011,234 cells

1460.010,497 cells

this.manuscript432,831 cells

GSE165578162,639 cells

OLI0747,941 cells

OLI0241,299 cells

OLI0639,405 cells

OLI0430,156 cells

OLI0328,414 cells

OLI0526,102 cells

OLI10.eae222,417 cells

OLI0113,667 cells

OLI11.eae311,227 cells

MIC04.mix10,850 cells

MIC03.210,608 cells

MIC03.110,036 cells

MIC09.eae59,783 cells

MIC03.39,755 cells

AST039,231 cells

OPC039,198 cells

MIC10.eae68,633 cells

OLI09.eae18,353 cells

OPC06.mix8,262 cells

MIC11.eae78,158 cells

IMM02.Mo28,087 cells

OLI08.mix8,009 cells

IMM03.Mo37,522 cells

IMM05.Mo57,120 cells

AST10.eae26,740 cells

AST01.36,421 cells

MIC07.eae35,873 cells

OPC11.eae55,698 cells

AST01.45,644 cells

MIC05.eae15,596 cells

MIC06.eae25,013 cells

OPC09.eae34,504 cells

IMM01.Mo13,805 cells

IMM07.Mφ23,793 cells

NEU.41.ext3,607 cells

AST09.eae13,572 cells

MIC08.eae43,527 cells

OPC07.eae13,498 cells

OPC10.eae43,495 cells

AST023,461 cells

NEU.44.ext3,309 cells

NEU.25.ext3,262 cells

NEU.13.ext3,227 cells

NEU.06.inh3,201 cells

NEU.30.ext3,169 cells

NEU.35.ext3,039 cells

NEU.36.ext2,918 cells

IMM10.moDC2,880 cells

NEU.34.ext2,835 cells

NEU.03.inh2,824 cells

AST01.22,687 cells

NEU.04.inh2,681 cells

NEU.15.ext2,674 cells

NEU.18.ext2,611 cells

NEU.27.ext2,584 cells

IMM04.Mo42,577 cells

NEU.19.ext2,542 cells

IMM22.Mo5cyc2,523 cells

NEU.28.ext2,519 cells

NEU.39.ext2,516 cells

NEU.24.ext2,473 cells

NEU.37.ext2,385 cells

MIC13.eae92,316 cells

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NEU.26.ext528 cells

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IMM13.cDC1413 cells

IMM31.CD8Tnk407 cells

VE1391 cells

NEU.45.ext382 cells

IMM24.moDCcyc359 cells

AST01.1285 cells

VLMC2266 cells

VE.eae1242 cells

Pericyte1240 cells

IMM27.γδT227 cells

MIC03.4214 cells

IMM09.Mφ4205 cells

IMM12.cDC2162 cells

IMM17.prePB151 cells

NEU.02.inh145 cells

VE.eae2144 cells

IMM14.pDC143 cells

IMM23.Mφcyc135 cells

IMM19.PBcyc121 cells

NEU.01.inh109 cells

NEU.10.inh105 cells

IMM06.Mφ193 cells

NEU.08.inh60 cells

VSMC48 cells

IMM16.Bact35 cells

VLMC432 cells

OLI07_SNCG47,941 cells

OLI02_LDB341,299 cells

OLI06_FRY39,405 cells

OLI04_MUSK30,156 cells

OLI03_SLCO1A228,414 cells

OLI05_MUSK26,102 cells

OLI10.eae2_SH3RF122,417 cells

OLI01_MARCH1013,667 cells

OLI11.eae3_SERPINB111,227 cells

MIC04.mix_CPE.S100A9.PCSK210,850 cells

MIC03.2_IGF1.CSF1.PCSK210,608 cells

MIC03.1_IGF1.C3.C510,036 cells

MIC09.eae5_S100A9.IGKC.C1QB9,783 cells

MIC03.3_IGF1.CPE.NAV29,755 cells

AST03_CPAMD8.HS3ST3A19,231 cells

OPC03_CCBE1.SLIT29,198 cells

MIC10.eae6_PPARG.PLTP.IGKC8,633 cells

OLI09.eae1_VAT1L8,353 cells

OPC06.mix_S100A9.CD748,262 cells

MIC11.eae7_PPARG.PLTP.ILDR18,158 cells

IMM02.Mo2_TMEM150C8,087 cells

OLI08.mix_TUBB2A8,009 cells

IMM03.Mo3_CD36.TSHR7,522 cells

IMM05.Mo5_CD36.TSHR.SLCO4C1.SLCO6A17,120 cells

AST10.eae2_CHI3L1.SERPINE16,740 cells

AST01.3_GRIA2.OLFM26,421 cells

MIC07.eae3_S100A9.IGFBP3.TUBB2B5,873 cells

OPC11.eae5_A2M.RASEF.CD44+5,698 cells

AST01.4_GRIA2.NEFL5,644 cells

MIC05.eae1_S100A9.CENPP.LCT5,596 cells

MIC06.eae2_S100A9.CENPP.TOP2A5,013 cells

OPC09.eae3_ALDH1A3.ERRFI1.CD44+4,504 cells

IMM01.Mo1_TMEM150C.SELL3,805 cells

IMM07.Mφ2_CD36.TSHR.PDK43,793 cells

NEU.41.ext3,607 cells

AST09.eae1_CHI3L1.GAP433,572 cells

MIC08.eae4_S100A9.IGKC.C1QA3,527 cells

OPC07.eae1_SDK2.S100A8.CD44-3,498 cells

OPC10.eae4_GAS7.CDH19.CD44+3,495 cells

AST02_MARCH4.CD743,461 cells

NEU.44.ext3,309 cells

NEU.25.ext3,262 cells

NEU.13.ext3,227 cells

NEU.06.inh3,201 cells

NEU.30.ext3,169 cells

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NEU.36.ext2,918 cells

IMM10.moDC_CD36.WARS.MRC12,880 cells

NEU.34.ext2,835 cells

NEU.03.inh2,824 cells

AST01.2_WIF1.SDS2,687 cells

NEU.04.inh2,681 cells

NEU.15.ext2,674 cells

NEU.18.ext2,611 cells

NEU.27.ext2,584 cells

IMM04.Mo4_CD36.TSHR2,577 cells

NEU.19.ext2,542 cells

IMM22.Mo5cyc2,523 cells

NEU.28.ext2,519 cells

NEU.39.ext2,516 cells

NEU.24.ext2,473 cells

NEU.37.ext2,385 cells

MIC13.eae9_ZNF804A.NABP1.C52,316 cells

MIC12.eae8_ZNF804A.ILDR1.SLCO6A12,294 cells

IMM21.Mo2-4cyc2,279 cells

NEU.05.inh2,252 cells

NEU.31.ext2,228 cells

NEU.14.ext2,162 cells

NEU.38.ext2,161 cells

VE3_FLT1.KIRREL32,055 cells

OPC01_STMN2.ATP1B12,049 cells

NEU.33.ext1,992 cells

NEU.17.ext1,837 cells

NEU.22.ext1,823 cells

NEU.11.inh1,774 cells

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NEU.07.inh1,680 cells

NEU.21.ext1,590 cells

NEU.16.ext1,531 cells

AST05_GMPR.EPHA61,496 cells

IMM30.CD8Tem_SKAP1.LEF11,462 cells

NEU.43.ext1,419 cells

Ependyma1,418 cells

NEU.40.ext1,398 cells

OPC08.eae2_CENPP.TOP2A.CD44+1,268 cells

NEU.12.ext1,188 cells

NEU.32.ext1,158 cells

NEU.20.ext1,122 cells

NEU.09.inh1,115 cells

IMM18.Plasma_OSBPL10.FCRL5.EAF2.ECE1.ACE.FRMPD31,089 cells

OPC05_GPC3.BMPER.ENPP6915 cells

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VE2_FLT1.ADGRG6893 cells

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NEU.29.ext844 cells

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OPC12.eae6_PTPRC.ITGAM.ITGAX.CD44+562 cells

VLMC1_CEMIP.PDGFRA555 cells

IMM11.DC3_CCSER1.IL17RA555 cells

IMM26.Tcyc538 cells

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NEU.26.ext528 cells

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IMM25.DCcyc469 cells

IMM13.cDC1_CCSER1.SLCO5A1.CPVL.IRF8413 cells

IMM31.CD8Tnk_SKAP1.KLRK1.KLRD1407 cells

VE1_FLT1.LAMA3391 cells

NEU.45.ext382 cells

IMM24.moDCcyc359 cells

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IMM27.γδT_SKAP1.ITGAM.ITGAX.PTPRG227 cells

MIC03.4_IGF1.GPC6.PFKFB2214 cells

IMM09.Mφ4_CD36.LYVE1.PDGFC205 cells

IMM12.cDC2_CCSER1.SLCO5A1.CCR7162 cells

IMM17.prePB_OSBPL10.FCRL5.EAF2.ACE151 cells

NEU.02.inh145 cells

VE.eae2_FLT1.S100A4.TIMP1144 cells

IMM14.pDC_SELL.OSBPL10.IRF8143 cells

IMM23.Mφcyc135 cells

IMM19.PBcyc121 cells

NEU.01.inh109 cells

NEU.10.inh105 cells

IMM06.Mφ1_CD36.IL17RA.ARHGAP3393 cells

NEU.08.inh60 cells

VSMC_KCNAB1.ACTA248 cells

IMM16.Bact_OSBPL10.FCRL5.EAF2.ARHGAP33.ECE135 cells

VLMC4_CEMIP.SLC47A132 cells

OLI276,990 cells

MIC92,656 cells

NEU87,590 cells

IMM51,658 cells

AST40,368 cells

OPC39,449 cells

VAS6,759 cells

10x Chromium 3’, single-nucleus595,470 cells

5-12 years595,470 cells

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Cluster 890,676 cells

Cluster 455,799 cells

Cluster 351,727 cells

Cluster 1046,015 cells

Cluster 139,989 cells

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Cluster 2018,978 cells

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Cluster 137,683 cells

Cluster 157,182 cells

Cluster 96,220 cells

Cluster 175,307 cells

Cluster 193,286 cells

Cluster 242,571 cells

Cluster 221,806 cells

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AST40,368 cells

OPC39,449 cells

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VE3,725 cells

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VLMC853 cells

IMM.CD4Tm740 cells

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IMM.γδT227 cells

IMM.cDC2162 cells

IMM.prePB151 cells

IMM.pDC143 cells

IMM.PBcyc121 cells

VSMC48 cells

IMM.Bact35 cells

2. Astrocytes

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

LMin days

LMax days

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Cell type

Leiden clustering

v3.9.22,289 cells

v3.2.22,127 cells

v3.9.51,900 cells

v3.9.71,825 cells

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v3.7.11,404 cells

v3.7.61,227 cells

v3.3.41,192 cells

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v3.6.31,172 cells

v3.3.11,154 cells

v3.8.51,146 cells

v3.8.31,015 cells

v3.9.6988 cells

v3.8.2944 cells

v3.6.4915 cells

v3.8.7887 cells

v3.7.5843 cells

v3.9.8832 cells

v3.8.1822 cells

v3.2.6818 cells

v3.7.3765 cells

v3.7.8748 cells

v3.8.4747 cells

v3.6.2732 cells

v3.3.2708 cells

v3.7.7666 cells

v3.9.4611 cells

v3.6.8540 cells

v3.3.3522 cells

v3.7.4492 cells

v3.6.6445 cells

v3.3.7416 cells

v3.6.5387 cells

v3.3.8371 cells

v3.1.1256 cells

v3.1.2238 cells

v3.1.3215 cells

v3.3.6212 cells

v3.1.4188 cells

CJR027,324 cells

CJH016,913 cells

CJH096,735 cells

CJM075,366 cells

CJP085,243 cells

CJG043,481 cells

CJP033,080 cells

CJR052,226 cells

F30,818 cells

M9,550 cells

2035 days7,324 cells

2051 days6,913 cells

2810 days6,735 cells

4102 days5,366 cells

2670 days5,243 cells

2503 days3,481 cells

2456 days3,080 cells

3246 days2,226 cells

20pWM8,390 cells

11pGM7,259 cells

19tWM6,536 cells

03fWM6,093 cells

06LGN5,456 cells

17OpT4,038 cells

18pCC2,170 cells

04aCC426 cells

WM27,653 cells

GM7,259 cells

other5,456 cells

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tWM7,940 cells

pCTX7,259 cells

pWM6,986 cells

fWM6,093 cells

LGN5,456 cells

OpT4,038 cells

pCC2,170 cells

aCC426 cells

SS08.R.C5,189 cells

SS05.L.C4,038 cells

SS03.L.C3,277 cells

SS08.L.B3,266 cells

SS06.R.B3,105 cells

SS06.R.C2,945 cells

SS08.L.A2,859 cells

SS06.L.C2,511 cells

SS04.L.A2,345 cells

SS07.L.A2,170 cells

SS08.L.C2,070 cells

SS06.L.A1,926 cells

SS06.L.B1,569 cells

SS05.L.A1,453 cells

SS05.R.A748 cells

SS03.R.A471 cells

SS03.R.B426 cells

T2.Lesion14,443 cells

He.Control14,237 cells

NA.Control3,764 cells

Re.Lesion3,380 cells

Ab.Tissue2,511 cells

Gd.Lesion2,033 cells

0D18,001 cells

<45D17,061 cells

>1000D5,306 cells

0~018,001 cells

7~413,476 cells

0~192,586 cells

0~972,289 cells

10~221,995 cells

10~231,900 cells

0~71,767 cells

1274~13481,404 cells

1348~13691,154 cells

0~201,146 cells

0~101,015 cells

1369~1383988 cells

0~21887 cells

1239~1274822 cells

1447~1460522 cells

1335~1348416 cells

experimental autoimmune encephalitis (EAE)26,131 cells

Ctrl14,237 cells

He.Control_0D14,237 cells

T2.Lesion_<45D12,517 cells

NA.Control_0D3,764 cells

Re.Lesion_>1000D3,380 cells

Ab.Tissue_<45D2,511 cells

Gd.Lesion_<45D2,033 cells

T2.Lesion_>1000D1,926 cells

WM_<45D12,480 cells

WM_0D9,867 cells

WM_>1000D5,306 cells

GM_0D5,189 cells

other_0D2,945 cells

other_<45D2,511 cells

GM_<45D2,070 cells

fWM_T2.Lesion4,735 cells

pWM_T2.Lesion3,609 cells

tWM_Re.Lesion3,380 cells

pCTX_He.Control3,364 cells

LGN_He.Control2,945 cells

LGN_Ab.Tissue2,511 cells

OpT_T2.Lesion2,474 cells

pWM_He.Control2,185 cells

pCTX_T2.Lesion2,070 cells

pCTX_NA.Control1,825 cells

tWM_He.Control1,652 cells

pCC_He.Control1,630 cells

OpT_He.Control1,564 cells

pWM_NA.Control1,192 cells

tWM_Gd.Lesion1,146 cells

tWM_T2.Lesion1,015 cells

fWM_Gd.Lesion887 cells

tWM_NA.Control747 cells

pCC_T2.Lesion540 cells

fWM_He.Control471 cells

aCC_He.Control426 cells

0.027,691 cells

10.03,895 cells

7.03,476 cells

1274.01,404 cells

1348.01,154 cells

1369.0988 cells

1239.0822 cells

1447.0522 cells

1335.0416 cells

0.018,001 cells

41.03,476 cells

19.02,586 cells

97.02,289 cells

22.01,995 cells

23.01,900 cells

1348.01,820 cells

7.01,767 cells

1369.01,154 cells

20.01,146 cells

10.01,015 cells

1383.0988 cells

21.0887 cells

1274.0822 cells

1460.0522 cells

this.manuscript26,131 cells

GSE16557814,237 cells

AST039,231 cells

AST10.eae26,740 cells

AST01.36,421 cells

AST01.45,644 cells

AST09.eae13,572 cells

AST023,461 cells

AST01.22,687 cells

AST051,496 cells

AST04831 cells

AST01.1285 cells

AST03_CPAMD8.HS3ST3A19,231 cells

AST10.eae2_CHI3L1.SERPINE16,740 cells

AST01.3_GRIA2.OLFM26,421 cells

AST01.4_GRIA2.NEFL5,644 cells

AST09.eae1_CHI3L1.GAP433,572 cells

AST02_MARCH4.CD743,461 cells

AST01.2_WIF1.SDS2,687 cells

AST05_GMPR.EPHA61,496 cells

AST04_GMPR.GRK5831 cells

AST01.1_WIF1.ADAMTS19285 cells

AST40,368 cells

10x Chromium 3’, single-nucleus40,368 cells

5-12 years40,368 cells

AST40,368 cells

Cluster 115,735 cells

Cluster 210,175 cells

Cluster 56,060 cells

Cluster 33,986 cells

Cluster 42,896 cells

Cluster 61,222 cells

Cluster 7294 cells

3. Mircroglia

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

LMin days

LMax days

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Cell type

Leiden clustering

v3.8.67,390 cells

v3.7.46,452 cells

v3.8.55,426 cells

v3.7.65,326 cells

v3.6.85,166 cells

v3.7.85,081 cells

v3.8.74,961 cells

v3.8.34,947 cells

v3.9.54,297 cells

v3.7.34,244 cells

v3.6.44,197 cells

v3.6.53,801 cells

v3.7.73,465 cells

v3.6.33,299 cells

v3.3.73,008 cells

v3.3.12,560 cells

v3.3.32,151 cells

v3.9.61,754 cells

v3.3.41,490 cells

v3.8.11,289 cells

v3.8.41,192 cells

v3.7.51,090 cells

v3.7.2926 cells

v3.8.2924 cells

v3.9.2903 cells

v3.6.2716 cells

v3.6.7647 cells

v3.7.1644 cells

v3.9.4618 cells

v3.9.8546 cells

v3.3.8526 cells

v3.3.2491 cells

v3.9.7468 cells

v3.2.6422 cells

v3.2.2389 cells

v3.6.6384 cells

v3.3.6342 cells

v3.4.5303 cells

v3.4.6268 cells

v3.1.3153 cells

v3.1.1152 cells

v3.1.2125 cells

v3.1.4122 cells

CJP0829,149 cells

CJM0723,424 cells

CJH0918,847 cells

CJP039,473 cells

CJR024,178 cells

CJH013,258 cells

CJG042,393 cells

CJR051,933 cells

F86,544 cells

M6,111 cells

2670 days29,149 cells

4102 days23,424 cells

2810 days18,847 cells

2456 days9,473 cells

2035 days4,178 cells

2051 days3,258 cells

2503 days2,393 cells

3246 days1,933 cells

20pWM28,329 cells

19tWM16,829 cells

03fWM15,313 cells

17OpT12,559 cells

11pGM7,455 cells

18pCC6,197 cells

06LGN5,726 cells

04aCC247 cells

WM79,474 cells

GM7,455 cells

other5,726 cells

Telencephalon74,370 cells

Diencephalon18,285 cells

pWM27,685 cells

tWM17,473 cells

fWM15,313 cells

OpT12,559 cells

pCTX7,455 cells

pCC6,197 cells

LGN5,726 cells

aCC247 cells

SS05.L.C12,559 cells

SS04.L.A12,351 cells

SS08.L.A11,622 cells

SS06.R.B11,297 cells

SS05.L.A6,999 cells

SS08.L.C6,416 cells

SS07.L.A6,197 cells

SS05.R.A5,081 cells

SS06.L.C4,915 cells

SS06.L.A3,983 cells

SS08.L.B3,695 cells

SS03.L.C2,657 cells

SS06.L.B2,481 cells

SS08.R.C1,039 cells

SS06.R.C811 cells

SS03.R.A305 cells

SS03.R.B247 cells

T2.Lesion62,274 cells

Gd.Lesion10,387 cells

He.Control7,436 cells

Ab.Tissue4,915 cells

Re.Lesion4,493 cells

NA.Control3,150 cells

<45D70,663 cells

>1000D11,406 cells

0D10,586 cells

7~4118,657 cells

0~1911,845 cells

0~010,586 cells

0~710,492 cells

10~229,135 cells

0~205,426 cells

0~214,961 cells

0~104,947 cells

10~234,297 cells

1335~13483,008 cells

1348~13692,560 cells

1447~14602,151 cells

1369~13831,754 cells

1239~12741,289 cells

0~97903 cells

1274~1348644 cells

experimental autoimmune encephalitis (EAE)85,219 cells

Ctrl7,436 cells

T2.Lesion_<45D55,361 cells

Gd.Lesion_<45D10,387 cells

He.Control_0D7,436 cells

T2.Lesion_>1000D6,913 cells

Ab.Tissue_<45D4,915 cells

Re.Lesion_>1000D4,493 cells

NA.Control_0D3,150 cells

WM_<45D59,332 cells

WM_>1000D11,406 cells

WM_0D8,736 cells

GM_<45D6,416 cells

other_<45D4,915 cells

GM_0D1,039 cells

other_0D811 cells

pWM_T2.Lesion24,401 cells

OpT_T2.Lesion11,297 cells

fWM_T2.Lesion10,047 cells

pCTX_T2.Lesion6,416 cells

tWM_Gd.Lesion5,426 cells

pCC_T2.Lesion5,166 cells

fWM_Gd.Lesion4,961 cells

tWM_T2.Lesion4,947 cells

LGN_Ab.Tissue4,915 cells

tWM_Re.Lesion4,493 cells

pWM_He.Control1,794 cells

pWM_NA.Control1,490 cells

tWM_He.Control1,415 cells

OpT_He.Control1,262 cells

tWM_NA.Control1,192 cells

pCC_He.Control1,031 cells

LGN_He.Control811 cells

pCTX_He.Control571 cells

pCTX_NA.Control468 cells

fWM_He.Control305 cells

aCC_He.Control247 cells

0.049,160 cells

7.018,657 cells

10.013,432 cells

1335.03,008 cells

1348.02,560 cells

1447.02,151 cells

1369.01,754 cells

1239.01,289 cells

1274.0644 cells

41.018,657 cells

19.011,845 cells

0.010,586 cells

7.010,492 cells

22.09,135 cells

20.05,426 cells

21.04,961 cells

10.04,947 cells

23.04,297 cells

1348.03,652 cells

1369.02,560 cells

1460.02,151 cells

1383.01,754 cells

1274.01,289 cells

97.0903 cells

this.manuscript85,219 cells

GSE1655787,436 cells

MIC04.mix10,850 cells

MIC03.210,608 cells

MIC03.110,036 cells

MIC09.eae59,783 cells

MIC03.39,755 cells

MIC10.eae68,633 cells

MIC11.eae78,158 cells

MIC07.eae35,873 cells

MIC05.eae15,596 cells

MIC06.eae25,013 cells

MIC08.eae43,527 cells

MIC13.eae92,315 cells

MIC12.eae82,294 cells

MIC03.4214 cells

MIC04.mix_CPE.S100A9.PCSK210,850 cells

MIC03.2_IGF1.CSF1.PCSK210,608 cells

MIC03.1_IGF1.C3.C510,036 cells

MIC09.eae5_S100A9.IGKC.C1QB9,783 cells

MIC03.3_IGF1.CPE.NAV29,755 cells

MIC10.eae6_PPARG.PLTP.IGKC8,633 cells

MIC11.eae7_PPARG.PLTP.ILDR18,158 cells

MIC07.eae3_S100A9.IGFBP3.TUBB2B5,873 cells

MIC05.eae1_S100A9.CENPP.LCT5,596 cells

MIC06.eae2_S100A9.CENPP.TOP2A5,013 cells

MIC08.eae4_S100A9.IGKC.C1QA3,527 cells

MIC13.eae9_ZNF804A.NABP1.C52,315 cells

MIC12.eae8_ZNF804A.ILDR1.SLCO6A12,294 cells

MIC03.4_IGF1.GPC6.PFKFB2214 cells

MIC92,655 cells

10x Chromium 3’, single-nucleus92,655 cells

5-12 years92,655 cells

MIC92,655 cells

Cluster 632,252 cells

Cluster 131,804 cells

Cluster 810,171 cells

Cluster 48,096 cells

Cluster 34,371 cells

Cluster 23,548 cells

Cluster 72,351 cells

Cluster 562 cells

4. Neurons

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

LMin days

LMax days

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Cell type

Leiden clustering

v3.4.615,632 cells

v3.4.511,314 cells

v3.9.79,842 cells

v3.7.17,773 cells

v3.7.55,443 cells

v3.9.24,732 cells

v3.7.64,531 cells

v3.9.54,348 cells

v3.2.24,006 cells

v3.6.72,702 cells

v3.2.62,259 cells

v3.7.21,791 cells

v3.8.31,317 cells

v3.8.61,282 cells

v3.9.61,079 cells

v3.8.71,025 cells

v3.3.2972 cells

v3.3.4895 cells

v3.8.1821 cells

v3.6.2656 cells

v3.9.4652 cells

v3.9.8501 cells

v3.3.8471 cells

v3.6.3463 cells

v3.1.4427 cells

v3.1.2335 cells

v3.3.3296 cells

v3.7.3290 cells

v3.6.4242 cells

v3.8.5239 cells

v3.3.7216 cells

v3.1.3170 cells

v3.3.1163 cells

v3.8.2152 cells

v3.1.1151 cells

v3.7.8119 cells

v3.7.7104 cells

v3.8.480 cells

v3.3.679 cells

v3.6.511 cells

v3.6.64 cells

v3.6.83 cells

v3.7.42 cells

CJR0223,789 cells

CJH0921,251 cells

CJH0117,833 cells

CJR058,594 cells

CJP086,712 cells

CJG045,627 cells

CJM072,030 cells

CJP031,754 cells

F55,207 cells

M32,383 cells

2035 days23,789 cells

2810 days21,251 cells

2051 days17,833 cells

3246 days8,594 cells

2670 days6,712 cells

2503 days5,627 cells

4102 days2,030 cells

2456 days1,754 cells

11pGM46,762 cells

20pWM12,036 cells

06LGN11,265 cells

03fWM8,439 cells

19tWM3,744 cells

18pCC2,709 cells

17OpT1,873 cells

04aCC762 cells

GM46,762 cells

WM29,563 cells

other11,265 cells

Telencephalon74,452 cells

Diencephalon13,138 cells

pCTX46,762 cells

tWM11,517 cells

LGN11,265 cells

fWM8,439 cells

pWM4,263 cells

pCC2,709 cells

OpT1,873 cells

aCC762 cells

SS08.R.C36,788 cells

SS08.L.C9,974 cells

SS08.L.B8,908 cells

SS06.R.C6,265 cells

SS03.L.C5,811 cells

SS06.L.C5,000 cells

SS07.L.A2,709 cells

SS04.L.A2,307 cells

SS08.L.A2,083 cells

SS05.L.C1,873 cells

SS06.R.B1,708 cells

SS06.L.A1,270 cells

SS06.L.B901 cells

SS05.L.A791 cells

SS03.R.B762 cells

SS03.R.A321 cells

SS05.R.A119 cells

He.Control41,622 cells

T2.Lesion20,130 cells

NA.Control10,817 cells

Re.Lesion8,757 cells

Ab.Tissue5,000 cells

Gd.Lesion1,264 cells

0D52,439 cells

<45D24,803 cells

>1000D10,348 cells

0~052,439 cells

1274~13487,773 cells

10~225,744 cells

0~974,732 cells

0~74,534 cells

10~234,348 cells

7~412,178 cells

0~101,317 cells

1369~13831,079 cells

0~211,025 cells

1239~1274821 cells

0~19686 cells

1447~1460296 cells

0~20239 cells

1335~1348216 cells

1348~1369163 cells

experimental autoimmune encephalitis (EAE)45,968 cells

Ctrl41,622 cells

He.Control_0D41,622 cells

T2.Lesion_<45D18,539 cells

NA.Control_0D10,817 cells

Re.Lesion_>1000D8,757 cells

Ab.Tissue_<45D5,000 cells

T2.Lesion_>1000D1,591 cells

Gd.Lesion_<45D1,264 cells

GM_0D36,788 cells

WM_>1000D10,348 cells

GM_<45D9,974 cells

WM_<45D9,829 cells

WM_0D9,386 cells

other_0D6,265 cells

other_<45D5,000 cells

pCTX_He.Control26,946 cells

pCTX_T2.Lesion9,974 cells

pCTX_NA.Control9,842 cells

tWM_Re.Lesion8,757 cells

fWM_T2.Lesion7,093 cells

LGN_He.Control6,265 cells

LGN_Ab.Tissue5,000 cells

pCC_He.Control2,706 cells

pWM_He.Control2,341 cells

tWM_T2.Lesion1,317 cells

OpT_He.Control1,157 cells

tWM_He.Control1,124 cells

pWM_T2.Lesion1,027 cells

fWM_Gd.Lesion1,025 cells

pWM_NA.Control895 cells

aCC_He.Control762 cells

OpT_T2.Lesion716 cells

fWM_He.Control321 cells

tWM_Gd.Lesion239 cells

tWM_NA.Control80 cells

pCC_T2.Lesion3 cells

0.064,972 cells

10.010,092 cells

1274.07,773 cells

7.02,178 cells

1369.01,079 cells

1239.0821 cells

1447.0296 cells

1335.0216 cells

1348.0163 cells

0.052,439 cells

1348.07,989 cells

22.05,744 cells

97.04,732 cells

7.04,534 cells

23.04,348 cells

41.02,178 cells

10.01,317 cells

1383.01,079 cells

21.01,025 cells

1274.0821 cells

19.0686 cells

1460.0296 cells

20.0239 cells

1369.0163 cells

this.manuscript45,968 cells

GSE16557841,622 cells

NEU.41.ext3,607 cells

NEU.44.ext3,309 cells

NEU.25.ext3,262 cells

NEU.13.ext3,227 cells

NEU.06.inh3,201 cells

NEU.30.ext3,169 cells

NEU.35.ext3,039 cells

NEU.36.ext2,918 cells

NEU.34.ext2,835 cells

NEU.03.inh2,824 cells

NEU.04.inh2,681 cells

NEU.15.ext2,674 cells

NEU.18.ext2,611 cells

NEU.27.ext2,584 cells

NEU.19.ext2,542 cells

NEU.28.ext2,519 cells

NEU.39.ext2,516 cells

NEU.24.ext2,473 cells

NEU.37.ext2,385 cells

NEU.05.inh2,252 cells

NEU.31.ext2,228 cells

NEU.14.ext2,162 cells

NEU.38.ext2,161 cells

NEU.33.ext1,992 cells

NEU.17.ext1,837 cells

NEU.22.ext1,823 cells

NEU.11.inh1,774 cells

NEU.23.ext1,756 cells

NEU.07.inh1,680 cells

NEU.21.ext1,590 cells

NEU.16.ext1,531 cells

NEU.43.ext1,419 cells

NEU.40.ext1,398 cells

NEU.12.ext1,188 cells

NEU.32.ext1,158 cells

NEU.20.ext1,122 cells

NEU.09.inh1,115 cells

NEU.42.ext855 cells

NEU.29.ext844 cells

NEU.26.ext528 cells

NEU.45.ext382 cells

NEU.02.inh145 cells

NEU.01.inh109 cells

NEU.10.inh105 cells

NEU.08.inh60 cells

NEU.41.ext3,607 cells

NEU.44.ext3,309 cells

NEU.25.ext3,262 cells

NEU.13.ext3,227 cells

NEU.06.inh3,201 cells

NEU.30.ext3,169 cells

NEU.35.ext3,039 cells

NEU.36.ext2,918 cells

NEU.34.ext2,835 cells

NEU.03.inh2,824 cells

NEU.04.inh2,681 cells

NEU.15.ext2,674 cells

NEU.18.ext2,611 cells

NEU.27.ext2,584 cells

NEU.19.ext2,542 cells

NEU.28.ext2,519 cells

NEU.39.ext2,516 cells

NEU.24.ext2,473 cells

NEU.37.ext2,385 cells

NEU.05.inh2,252 cells

NEU.31.ext2,228 cells

NEU.14.ext2,162 cells

NEU.38.ext2,161 cells

NEU.33.ext1,992 cells

NEU.17.ext1,837 cells

NEU.22.ext1,823 cells

NEU.11.inh1,774 cells

NEU.23.ext1,756 cells

NEU.07.inh1,680 cells

NEU.21.ext1,590 cells

NEU.16.ext1,531 cells

NEU.43.ext1,419 cells

NEU.40.ext1,398 cells

NEU.12.ext1,188 cells

NEU.32.ext1,158 cells

NEU.20.ext1,122 cells

NEU.09.inh1,115 cells

NEU.42.ext855 cells

NEU.29.ext844 cells

NEU.26.ext528 cells

NEU.45.ext382 cells

NEU.02.inh145 cells

NEU.01.inh109 cells

NEU.10.inh105 cells

NEU.08.inh60 cells

NEU87,590 cells

10x Chromium 3’, single-nucleus87,590 cells

5-12 years87,590 cells

NEU.ext71,644 cells

NEU.inh15,946 cells

Cluster 114,586 cells

Cluster 1712,190 cells

Cluster 611,101 cells

Cluster 138,826 cells

Cluster 108,529 cells

Cluster 166,892 cells

Cluster 76,652 cells

Cluster 53,098 cells

Cluster 83,028 cells

Cluster 142,540 cells

Cluster 152,349 cells

Cluster 31,995 cells

Cluster 41,935 cells

Cluster 181,739 cells

Cluster 21,160 cells

Cluster 9687 cells

Cluster 11243 cells

Cluster 1240 cells

5. Oligodendrocytes

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

Sequencing platform

Batch ID

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Cell type

Leiden clustering

v3.3.415,241 cells

v3.7.711,414 cells

v3.3.111,404 cells

v3.7.211,352 cells

v3.8.411,140 cells

v3.8.110,354 cells

v3.6.710,155 cells

v3.7.810,110 cells

v3.8.29,913 cells

v3.6.69,787 cells

v3.3.78,727 cells

v3.8.78,717 cells

v3.3.28,430 cells

v3.9.28,234 cells

v3.8.58,063 cells

v3.8.37,989 cells

v3.9.57,586 cells

v3.7.37,014 cells

v3.3.36,943 cells

v3.6.86,817 cells

v3.8.66,607 cells

v3.9.66,599 cells

v3.3.86,272 cells

v3.9.76,067 cells

v3.6.35,984 cells

v3.7.14,588 cells

v3.2.24,558 cells

v3.7.64,511 cells

v3.3.64,509 cells

v3.4.54,225 cells

v3.6.23,728 cells

v3.9.83,583 cells

v3.4.63,395 cells

v3.2.63,370 cells

v3.7.53,043 cells

v3.6.42,823 cells

v3.9.42,734 cells

v3.7.42,704 cells

v3.6.52,142 cells

v3.1.41,970 cells

v3.1.31,820 cells

v3.1.21,503 cells

v3.1.1864 cells

CJM0755,428 cells

CJR0245,703 cells

CJH0143,731 cells

CJH0933,841 cells

CJP0333,673 cells

CJP0826,196 cells

CJG0423,475 cells

CJR0514,942 cells

F216,344 cells

M60,645 cells

4102 days55,428 cells

2035 days45,703 cells

2051 days43,731 cells

2810 days33,841 cells

2456 days33,673 cells

2670 days26,196 cells

2503 days23,475 cells

3246 days14,942 cells

20pWM88,874 cells

19tWM67,293 cells

03fWM32,841 cells

18pCC26,759 cells

11pGM21,241 cells

17OpT18,260 cells

06LGN18,248 cells

04aCC3,473 cells

WM237,500 cells

GM21,241 cells

other18,248 cells

Telencephalon240,481 cells

Diencephalon36,508 cells

pWM84,286 cells

tWM71,881 cells

fWM32,841 cells

pCC26,759 cells

pCTX21,241 cells

OpT18,260 cells

LGN18,248 cells

aCC3,473 cells

SS08.L.A45,492 cells

SS07.L26,759 cells

SS06.L.A26,693 cells

SS05.L.A26,413 cells

SS06.R.B25,965 cells

SS06.L.B21,494 cells

SS05.L18,260 cells

SS04.L.A15,324 cells

SS03.L14,833 cells

SS08.L13,621 cells

SS06.L10,320 cells

SS05.R.A10,110 cells

SS06.R7,928 cells

SS08.R.A7,620 cells

SS03.R6,157 cells

T2.Lesion101,661 cells

He.Control89,434 cells

NA.Control32,448 cells

Re.Lesion26,346 cells

Gd.Lesion16,780 cells

Ab.Tissue10,320 cells

0D121,882 cells

<45D106,492 cells

>1000D48,615 cells

0_0121,882 cells

0_1927,508 cells

7_4114,868 cells

10_2212,199 cells

1348_136911,404 cells

0_711,328 cells

1239_127410,354 cells

1335_13488,727 cells

0_218,717 cells

0_978,234 cells

0_208,063 cells

0_107,989 cells

10_237,586 cells

1447_14606,943 cells

1369_13836,599 cells

1274_13484,588 cells

experimental autoimmune encephalitis (EAE)187,555 cells

Ctrl89,434 cells

He.Control_0D89,434 cells

T2.Lesion_<45D79,392 cells

NA.Control_0D32,448 cells

Re.Lesion_>1000D26,346 cells

T2.Lesion_>1000D22,269 cells

Gd.Lesion_<45D16,780 cells

Ab.Tissue_<45D10,320 cells

WM_0D100,267 cells

WM_<45D88,618 cells

WM_>1000D48,615 cells

GM_0D13,687 cells

other_<45D10,320 cells

other_0D7,928 cells

GM_<45D7,554 cells

pWM_T2.Lesion46,912 cells

pWM_He.Control22,133 cells

tWM_Re.Lesion21,758 cells

fWM_T2.Lesion21,440 cells

pCC_He.Control19,942 cells

tWM_He.Control18,343 cells

pWM_NA.Control15,241 cells

tWM_NA.Control11,140 cells

OpT_T2.Lesion10,949 cells

LGN_Ab.Tissue10,320 cells

fWM_Gd.Lesion8,717 cells

tWM_Gd.Lesion8,063 cells

tWM_T2.Lesion7,989 cells

LGN_He.Control7,928 cells

pCTX_He.Control7,620 cells

pCTX_T2.Lesion7,554 cells

OpT_He.Control7,311 cells

pCC_T2.Lesion6,817 cells

pCTX_NA.Control6,067 cells

pWM_Re.Lesion4,588 cells

aCC_He.Control3,473 cells

fWM_He.Control2,684 cells

NovaS2270,832 cells

Hi40006,157 cells

8th62,783 cells

3rd61,526 cells

7th54,736 cells

6th41,436 cells

9th34,803 cells

2nd7,928 cells

4th7,620 cells

1st6,157 cells

this.manuscript187,555 cells

GSE16557889,434 cells

OLI0747,941 cells

OLI0241,299 cells

OLI0639,405 cells

OLI0430,156 cells

OLI0328,413 cells

OLI0526,102 cells

OLI10.eae222,417 cells

OLI0113,667 cells

OLI11.eae311,227 cells

OLI09.eae18,353 cells

OLI08.mix8,009 cells

OLI07_SNCG47,941 cells

OLI02_LDB341,299 cells

OLI06_FRY39,405 cells

OLI04_MUSK30,156 cells

OLI03_SLCO1A228,413 cells

OLI05_MUSK26,102 cells

OLI10.eae2_SH3RF122,417 cells

OLI01_MARCH1013,667 cells

OLI11.eae3_SERPINB111,227 cells

OLI09.eae1_VAT1L8,353 cells

OLI08.mix_TUBB2A8,009 cells

OLI276,989 cells

10x Chromium 3’, single-nucleus276,989 cells

5-12 years276,989 cells

OLI276,989 cells

Cluster 288,122 cells

Cluster 179,919 cells

Cluster 375,777 cells

Cluster 432,385 cells

Cluster 5786 cells

6. OPCs

Explore

Sample ID

Subject ID

Sex

Age

Tissue (detail)

Tissue (coarse)

Tissue

Tissue (fine)

Location

Disease - status

Disease - maxDay

Disease - range

Disease

Disease - status - maxDays

Disease - Tissue - maxDays

Disease - Tissue - status

Sample source

Cell type (cluster)

Cell type (marker)

Cell type (major)

Assay

Age group

Cell type

Leiden clustering

v3.6.42,399 cells

v3.8.52,377 cells

v3.7.81,936 cells

v3.8.61,933 cells

v3.6.81,764 cells

v3.6.31,755 cells

v3.8.31,626 cells

v3.7.31,622 cells

v3.8.71,429 cells

v3.7.71,379 cells

v3.6.51,354 cells

v3.3.41,264 cells

v3.9.51,188 cells

v3.7.61,107 cells

v3.8.41,038 cells

v3.7.41,013 cells

v3.8.2974 cells

v3.9.2911 cells

v3.8.1905 cells

v3.3.1866 cells

v3.7.2775 cells

v3.9.7730 cells

v3.9.6678 cells

v3.3.2648 cells

v3.3.7598 cells

v3.6.6585 cells

v3.6.7546 cells

v3.2.2537 cells

v3.6.2523 cells

v3.7.1520 cells

v3.7.5509 cells

v3.4.6483 cells

v3.4.5478 cells

v3.3.3476 cells

v3.9.8463 cells

v3.3.8459 cells

v3.2.6396 cells

v3.9.4356 cells

v3.3.6303 cells

v3.1.3149 cells

v3.1.2138 cells

v3.1.1137 cells

v3.1.4122 cells

CJM079,914 cells

CJP088,572 cells

CJH097,029 cells

CJR023,968 cells

CJH013,748 cells

CJP032,618 cells

CJG042,175 cells

CJR051,425 cells

F34,056 cells

M5,393 cells

4102 days9,914 cells

2670 days8,572 cells

2810 days7,029 cells

2035 days3,968 cells

2051 days3,748 cells

2456 days2,618 cells

2503 days2,175 cells

3246 days1,425 cells

20pWM10,345 cells

19tWM8,434 cells

17OpT6,494 cells

03fWM5,237 cells

11pGM3,307 cells

18pCC2,895 cells

06LGN2,477 cells

04aCC260 cells

WM33,665 cells

GM3,307 cells

other2,477 cells

Telencephalon30,478 cells

Diencephalon8,971 cells

pWM9,825 cells

tWM8,954 cells

OpT6,494 cells

fWM5,237 cells

pCTX3,307 cells

pCC2,895 cells

LGN2,477 cells

aCC260 cells

SS05.L.C6,494 cells

SS06.R.B4,977 cells

SS08.L.A3,410 cells

SS04.L.A3,362 cells

SS07.L.A2,895 cells

SS05.L.A2,436 cells

SS06.L.A2,043 cells

SS08.L.B2,034 cells

SS06.L.B1,943 cells

SS05.R.A1,936 cells

SS08.R.C1,691 cells

SS08.L.C1,616 cells

SS03.L.C1,589 cells

SS06.L.C1,544 cells

SS06.R.C933 cells

SS03.R.A286 cells

SS03.R.B260 cells

T2.Lesion21,060 cells

He.Control7,716 cells

Gd.Lesion3,806 cells

NA.Control3,032 cells

Re.Lesion2,291 cells

Ab.Tissue1,544 cells

<45D24,658 cells

0D10,748 cells

>1000D4,043 cells

0~010,748 cells

7~415,701 cells

0~195,070 cells

10~223,485 cells

0~72,871 cells

0~202,377 cells

0~101,626 cells

0~211,429 cells

10~231,188 cells

0~97911 cells

1239~1274905 cells

1348~1369866 cells

1369~1383678 cells

1335~1348598 cells

1274~1348520 cells

1447~1460476 cells

experimental autoimmune encephalitis (EAE)31,733 cells

Ctrl7,716 cells

T2.Lesion_<45D19,308 cells

He.Control_0D7,716 cells

Gd.Lesion_<45D3,806 cells

NA.Control_0D3,032 cells

Re.Lesion_>1000D2,291 cells

T2.Lesion_>1000D1,752 cells

Ab.Tissue_<45D1,544 cells

WM_<45D21,498 cells

WM_0D8,124 cells

WM_>1000D4,043 cells

GM_0D1,691 cells

GM_<45D1,616 cells

other_<45D1,544 cells

other_0D933 cells

pWM_T2.Lesion7,024 cells

OpT_T2.Lesion5,508 cells

fWM_T2.Lesion3,522 cells

tWM_Gd.Lesion2,377 cells

tWM_Re.Lesion2,291 cells

pCC_T2.Lesion1,764 cells

tWM_T2.Lesion1,626 cells

tWM_He.Control1,622 cells

pCTX_T2.Lesion1,616 cells

LGN_Ab.Tissue1,544 cells

pWM_He.Control1,537 cells

fWM_Gd.Lesion1,429 cells

pWM_NA.Control1,264 cells

pCC_He.Control1,131 cells

tWM_NA.Control1,038 cells

OpT_He.Control986 cells

pCTX_He.Control961 cells

LGN_He.Control933 cells

pCTX_NA.Control730 cells

fWM_He.Control286 cells

aCC_He.Control260 cells

this.manuscript31,733 cells

GSE1655787,716 cells

OPC039,198 cells

OPC06.mix8,262 cells

OPC11.eae55,698 cells

OPC09.eae34,504 cells

OPC07.eae13,498 cells

OPC10.eae43,495 cells

OPC012,049 cells

OPC08.eae21,268 cells

OPC05915 cells

OPC12.eae6562 cells

OPC03_CCBE1.SLIT29,198 cells

OPC06.mix_S100A9.CD748,262 cells

OPC11.eae5_A2M.RASEF.CD44+5,698 cells

OPC09.eae3_ALDH1A3.ERRFI1.CD44+4,504 cells

OPC07.eae1_SDK2.S100A8.CD44-3,498 cells

OPC10.eae4_GAS7.CDH19.CD44+3,495 cells

OPC01_STMN2.ATP1B12,049 cells

OPC08.eae2_CENPP.TOP2A.CD44+1,268 cells

OPC05_GPC3.BMPER.ENPP6915 cells

OPC12.eae6_PTPRC.ITGAM.ITGAX.CD44+562 cells

OPC39,449 cells

10x Chromium 3’, single-nucleus39,449 cells

5-12 years39,449 cells

OPC39,449 cells

Cluster 219,168 cells

Cluster 812,141 cells

Cluster 34,583 cells

Cluster 61,112 cells

Cluster 71,032 cells

Cluster 4732 cells

Cluster 5579 cells

Cluster 1102 cells