A panoramic view of cell population dynamics in mammalian aging

Cite

Zhang, Z., Schaefer, C., Jiang, W., Lu, Z., Lee, J., Sziraki, A., Abdulraouf, A., Wick, B., Haeussler, M., Li, Z. and Molla, G., 2024. A panoramic view of cell population dynamics in mammalian aging. Science, 387(6731), p.eadn3949. https://doi.org/10.1126/science.adn3949

Abstract

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.

Datasets

1. Inguinal white adipose tissue

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 2154964 cells

Cluster 3101191 cells

Cluster 1043277 cells

Cluster 839178 cells

Cluster 1235145 cells

Cluster 1434423 cells

Cluster 3127978 cells

Cluster 2826673 cells

Cluster 2622771 cells

Cluster 2221123 cells

Cluster 2521105 cells

Cluster 2920440 cells

Cluster 2720360 cells

Cluster 1820355 cells

Cluster 2420334 cells

Cluster 119391 cells

Cluster 1718253 cells

Cluster 3417598 cells

Cluster 3217571 cells

Cluster 3614543 cells

Cluster 2313771 cells

Cluster 1113069 cells

Cluster 3012759 cells

Cluster 512033 cells

Cluster 411934 cells

Cluster 1310609 cells

Cluster 3310363 cells

Cluster 2110087 cells

Cluster 199564 cells

Cluster 69535 cells

Cluster 169238 cells

Cluster 378372 cells

Cluster 158054 cells

Cluster 356781 cells

Cluster 96633 cells

Cluster 404350 cells

Cluster 394013 cells

Cluster 202167 cells

Cluster 38650 cells

Cluster 7461 cells

WT592116 cells

Prkdc148982 cells

Rag120018 cells

Male504106 cells

Female357010 cells

3 months250338 cells

23 months181636 cells

16 months176842 cells

6 months137795 cells

12 months114505 cells

Inguinal white adipose tissue (iWAT)861116 cells

Adipocytes234867 cells

Lymphoid cells_B cells154011 cells

Lymphoid cells_T cells142589 cells

Vascular endothelial cells95908 cells

Adipoce stem and progenitor cells94483 cells

Myeloid cells82119 cells

Mural cells28428 cells

Myeloid cells_Dendritic cells14114 cells

Neural cells7058 cells

Lymphoid cells_Plasma cells4180 cells

Skeletal muscle cells1754 cells

Lymphatic endothelial cells1605 cells

Immune397013 cells

Adipose329350 cells

Endothelial97513 cells

Stromal28428 cells

Neural7058 cells

Muscle1754 cells

Cluster 10237265 cells

Cluster 11109383 cells

Cluster 182349 cells

Cluster 1778365 cells

Cluster 466275 cells

Cluster 2361654 cells

Cluster 556908 cells

Cluster 1953671 cells

Cluster 241489 cells

Cluster 1237592 cells

Cluster 629138 cells

Cluster 223112 cells

Cluster 271345 cells

Cluster 20798 cells

Cluster 24383 cells

Cluster 37368 cells

Cluster 28326 cells

Cluster 49262 cells

Cluster 3362 cells

Cluster 2160 cells

Cluster 3859 cells

Cluster 1544 cells

Cluster 742 cells

Cluster 4338 cells

Cluster 326 cells

Cluster 4024 cells

Cluster 1620 cells

Cluster 1311 cells

Cluster 4210 cells

Cluster 3010 cells

Cluster 396 cells

Cluster 355 cells

Cluster 464 cells

Cluster 04 cells

Cluster 482 cells

Cluster 502 cells

Cluster 91 cells

Cluster 471 cells

Cluster 81 cells

Cluster 141 cells

EasySci, single-nucleus861116 cells

flash-freeze in liquid nitrogen861116 cells

normal592116 cells

immuno-deficient269000 cells

C57BL/6592116 cells

B6.Cg-Prkdcscid/SzJ148982 cells

B6.129S7-Rag1tm1Mom/J120018 cells

2. Brown adipose tissue

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 11286454 cells

Cluster 21206168 cells

Cluster 10188372 cells

Cluster 2681893 cells

Cluster 565001 cells

Cluster 1654736 cells

Cluster 1548356 cells

Cluster 646303 cells

Cluster 1240331 cells

Cluster 133097 cells

Cluster 1432390 cells

Cluster 1331199 cells

Cluster 2329955 cells

Cluster 2429341 cells

Cluster 1929318 cells

Cluster 427194 cells

Cluster 327167 cells

Cluster 225614 cells

Cluster 1823132 cells

Cluster 2220900 cells

Cluster 818707 cells

Cluster 2716881 cells

Cluster 2514972 cells

Cluster 2013555 cells

Cluster 1712802 cells

Cluster 79578 cells

Cluster 282817 cells

Cluster 292426 cells

Cluster 91170 cells

Cluster 30994 cells

Cluster 31515 cells

WT991729 cells

Rag242847 cells

Prkdc186762 cells

Female732878 cells

Male688460 cells

16 months362012 cells

3 months297893 cells

23 months277505 cells

12 months256015 cells

6 months227913 cells

Brown adipose tissue (BAT)1421338 cells

Brown adipocytes708421 cells

Vascular endothelial cells466623 cells

Mural cells66449 cells

Adipocytes61301 cells

Adipoce stem and progenitor cells50093 cells

Myeloid cells31685 cells

Lymphoid cells_T cells11335 cells

Lymphoid cells_B cells9413 cells

Skeletal muscle cells8337 cells

Neural cells7057 cells

Fcgbp positive cells557 cells

Circulating hepatoblasts67 cells

Adipose820372 cells

Endothelial466623 cells

Stromal66449 cells

Immune52433 cells

Muscle8337 cells

Neural7057 cells

Epithelial67 cells

Cluster 24378941 cells

Cluster 28340059 cells

Cluster 4232191 cells

Cluster 6231564 cells

Cluster 1063033 cells

Cluster 157405 cells

Cluster 255160 cells

Cluster 1215201 cells

Cluster 513260 cells

Cluster 278578 cells

Cluster 176427 cells

Cluster 225645 cells

Cluster 115438 cells

Cluster 233917 cells

Cluster 193255 cells

Cluster 21615 cells

Cluster 20257 cells

Cluster 37158 cells

Cluster 340 cells

Cluster 4328 cells

Cluster 1320 cells

Cluster 3518 cells

Cluster 4217 cells

Cluster 4915 cells

Cluster 1514 cells

Cluster 3311 cells

Cluster 169 cells

Cluster 478 cells

Cluster 77 cells

Cluster 07 cells

Cluster 386 cells

Cluster 95 cells

Cluster 304 cells

Cluster 84 cells

Cluster 264 cells

Cluster 464 cells

Cluster 403 cells

Cluster 393 cells

Cluster 342 cells

Cluster 411 cells

Cluster 451 cells

Cluster 251 cells

Cluster 181 cells

Cluster 141 cells

EasySci, single-nucleus1421338 cells

flash-freeze in liquid nitrogen1421338 cells

normal991729 cells

immuno-deficient429609 cells

C57BL/6991729 cells

B6.129S7-Rag1tm1Mom/J242847 cells

B6.Cg-Prkdcscid/SzJ186762 cells

3. Perigonadal white adipose tissue

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 10139116 cells

Cluster 15120300 cells

Cluster 14108372 cells

Cluster 13102617 cells

Cluster 378192 cells

Cluster 261587 cells

Cluster 150731 cells

Cluster 948384 cells

Cluster 643774 cells

Cluster 743296 cells

Cluster 1640730 cells

Cluster 527611 cells

Cluster 416437 cells

Cluster 814761 cells

Cluster 1913290 cells

Cluster 119629 cells

Cluster 188568 cells

Cluster 206195 cells

Cluster 173979 cells

Cluster 121283 cells

WT700124 cells

Rag123026 cells

Prkdc115702 cells

Male492514 cells

Female446338 cells

3 months297451 cells

23 months190411 cells

6 months186467 cells

12 months156133 cells

16 months108390 cells

Perigonadal white adipose tissue (gWAT)938852 cells

Adipocytes309666 cells

Vascular endothelial cells166654 cells

Myeloid cells131797 cells

Adipoce stem and progenitor cells112515 cells

Mural cells57749 cells

Lymphoid cells_T cells52066 cells

Lymphoid cells_B cells43173 cells

Skeletal muscle cells16501 cells

Rdh16 positive cells13039 cells

Mesothelial cells9436 cells

Lymphoid cells_Plasma cells8797 cells

Myeloid cells_Dendritic cells8280 cells

Epididymal cells7920 cells

Neural cells683 cells

Erythroblasts576 cells

Adipose422181 cells

Immune244689 cells

Endothelial166654 cells

Stromal57749 cells

Epithelial30395 cells

Muscle16501 cells

Neural683 cells

Cluster 10328853 cells

Cluster 4131692 cells

Cluster 1113281 cells

Cluster 592692 cells

Cluster 648278 cells

Cluster 1247084 cells

Cluster 245334 cells

Cluster 1129714 cells

Cluster 1725432 cells

Cluster 2325181 cells

Cluster 1922568 cells

Cluster 166488 cells

Cluster 505867 cells

Cluster 304890 cells

Cluster 224667 cells

Cluster 201438 cells

Cluster 371397 cells

Cluster 241247 cells

Cluster 281236 cells

Cluster 27815 cells

Cluster 21148 cells

Cluster 0109 cells

Cluster 4371 cells

Cluster 1557 cells

Cluster 745 cells

Cluster 4744 cells

Cluster 337 cells

Cluster 4935 cells

Cluster 4628 cells

Cluster 3826 cells

Cluster 821 cells

Cluster 4218 cells

Cluster 3317 cells

Cluster 1315 cells

Cluster 3511 cells

Cluster 189 cells

Cluster 404 cells

Cluster 482 cells

Cluster 311 cells

EasySci, single-nucleus938852 cells

flash-freeze in liquid nitrogen938852 cells

normal700124 cells

immuno-deficient238728 cells

C57BL/6700124 cells

B6.129S7-Rag1tm1Mom/J123026 cells

B6.Cg-Prkdcscid/SzJ115702 cells

4. Colon

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 1495143 cells

Cluster 1576931 cells

Cluster 3175259 cells

Cluster 2470812 cells

Cluster 468157 cells

Cluster 2063864 cells

Cluster 762768 cells

Cluster 1960624 cells

Cluster 3954137 cells

Cluster 1045317 cells

Cluster 1243899 cells

Cluster 2140516 cells

Cluster 4333640 cells

Cluster 2732735 cells

Cluster 1632699 cells

Cluster 2232403 cells

Cluster 2331757 cells

Cluster 930822 cells

Cluster 125985 cells

Cluster 4518325 cells

Cluster 2516932 cells

Cluster 616044 cells

Cluster 2915462 cells

Cluster 1815354 cells

Cluster 3814677 cells

Cluster 1314652 cells

Cluster 3413999 cells

Cluster 1713667 cells

Cluster 3013254 cells

Cluster 1113227 cells

Cluster 4213216 cells

Cluster 4010908 cells

Cluster 369040 cells

Cluster 328644 cells

Cluster 538302 cells

Cluster 488120 cells

Cluster 497740 cells

Cluster 27355 cells

Cluster 517306 cells

Cluster 446618 cells

Cluster 356178 cells

Cluster 286163 cells

Cluster 85457 cells

Cluster 415450 cells

Cluster 525029 cells

Cluster 375002 cells

Cluster 564873 cells

Cluster 334689 cells

Cluster 504501 cells

Cluster 544185 cells

Cluster 263867 cells

Cluster 53730 cells

Cluster 33073 cells

Cluster 463008 cells

Cluster 472630 cells

Cluster 552051 cells

WT1300196 cells

Male666324 cells

Female633872 cells

3 months293788 cells

23 months277996 cells

12 months266809 cells

16 months238139 cells

6 months223464 cells

Colon1300196 cells

Colonic epithelial cells579844 cells

Goblet cells266702 cells

Fibroblasts154848 cells

Lymphoid cells_B cells63845 cells

Lymphoid cells_T cells46239 cells

Myeloid cells45190 cells

Mural cells35513 cells

Lymphoid cells_Plasma cells30742 cells

Enteroendocrine cells23961 cells

Lymphatic endothelial cells15343 cells

Enteric glia9185 cells

Tuft cells7193 cells

Enteric neurons5521 cells

Ngf positive cells4382 cells

Adipocytes3278 cells

Mesothelial cells2501 cells

Sis positive cells2229 cells

Mfge8 positive cells2220 cells

Myeloid cells_Dendritic cells1460 cells

Epithelial882430 cells

Stromal196963 cells

Immune187476 cells

Endothelial15343 cells

Neural14706 cells

Adipose3278 cells

Cluster 7347419 cells

Cluster 15276309 cells

Cluster 34132941 cells

Cluster 36129786 cells

Cluster 187917 cells

Cluster 274326 cells

Cluster 1153666 cells

Cluster 1939956 cells

Cluster 1728434 cells

Cluster 1227037 cells

Cluster 418457 cells

Cluster 517575 cells

Cluster 2315659 cells

Cluster 2215369 cells

Cluster 469963 cells

Cluster 208473 cells

Cluster 424054 cells

Cluster 103120 cells

Cluster 62433 cells

Cluster 92095 cells

Cluster 262045 cells

Cluster 371960 cells

Cluster 35826 cells

Cluster 14144 cells

Cluster 4967 cells

Cluster 2160 cells

Cluster 1622 cells

Cluster 3315 cells

Cluster 2415 cells

Cluster 3011 cells

Cluster 08 cells

Cluster 398 cells

Cluster 287 cells

Cluster 473 cells

Cluster 503 cells

Cluster 453 cells

Cluster 132 cells

Cluster 32 cells

Cluster 432 cells

Cluster 81 cells

Cluster 441 cells

Cluster 401 cells

Cluster 181 cells

EasySci, single-nucleus1300196 cells

flash-freeze in liquid nitrogen1300196 cells

normal1300196 cells

C57BL/61300196 cells

5. Duodenum

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 191844 cells

Cluster 554613 cells

Cluster 2850812 cells

Cluster 4447140 cells

Cluster 246382 cells

Cluster 3635765 cells

Cluster 1634307 cells

Cluster 3825297 cells

Cluster 322749 cells

Cluster 4520106 cells

Cluster 3419676 cells

Cluster 619426 cells

Cluster 2416115 cells

Cluster 914369 cells

Cluster 4113808 cells

Cluster 412783 cells

Cluster 2912474 cells

Cluster 811840 cells

Cluster 2511354 cells

Cluster 2311262 cells

Cluster 7211115 cells

Cluster 5410951 cells

Cluster 4710588 cells

Cluster 1110476 cells

Cluster 1410365 cells

Cluster 2610203 cells

Cluster 3210061 cells

Cluster 359516 cells

Cluster 209357 cells

Cluster 379146 cells

Cluster 468653 cells

Cluster 188558 cells

Cluster 628426 cells

Cluster 398175 cells

Cluster 438104 cells

Cluster 487721 cells

Cluster 507487 cells

Cluster 177293 cells

Cluster 587160 cells

Cluster 317093 cells

Cluster 536906 cells

Cluster 426648 cells

Cluster 566255 cells

Cluster 516048 cells

Cluster 525928 cells

Cluster 495857 cells

Cluster 135839 cells

Cluster 615837 cells

Cluster 675578 cells

Cluster 215571 cells

Cluster 575452 cells

Cluster 405199 cells

Cluster 715160 cells

Cluster 195104 cells

Cluster 555051 cells

Cluster 604985 cells

Cluster 734967 cells

Cluster 634904 cells

Cluster 104842 cells

Cluster 664761 cells

Cluster 684720 cells

Cluster 274675 cells

Cluster 744646 cells

Cluster 334526 cells

Cluster 304420 cells

Cluster 693957 cells

Cluster 73760 cells

Cluster 123554 cells

Cluster 653270 cells

Cluster 703148 cells

Cluster 222194 cells

Cluster 641561 cells

Cluster 591192 cells

Cluster 15820 cells

WT672673 cells

Prkdc122806 cells

Rag114426 cells

Female476253 cells

Male433652 cells

3 months228606 cells

23 months210096 cells

12 months171588 cells

6 months160103 cells

16 months139512 cells

Duodenum909905 cells

Intestinal epithelial cells507299 cells

Lymphoid cells_T cells93481 cells

Fibroblasts68315 cells

Myeloid cells46299 cells

Muc2-producing goblet cells37793 cells

Lymphoid cells_B cells36971 cells

Lymphoid cells_Plasma cells35264 cells

Myeloid cells_Dendritic cells17951 cells

Paneth cells17370 cells

Enteroendocrine cells11106 cells

Mural cells10650 cells

Muc6-producing goblet cells6954 cells

Tuft cells5531 cells

Lymphatic endothelial cells4268 cells

Muc5ac-producing goblet cells2925 cells

Enteric glia1335 cells

Mfge8 positive cells1276 cells

Enteric neurons1231 cells

Pancreatic acinar cells1136 cells

Mesothelial cells1070 cells

Ngf positive cells811 cells

Adipocytes624 cells

Myeloid cells_Mast cells245 cells

Epithelial591184 cells

Immune230211 cells

Stromal81052 cells

Endothelial4268 cells

Neural2566 cells

Adipose624 cells

Cluster 9240656 cells

Cluster 7155994 cells

Cluster 2687714 cells

Cluster 1575202 cells

Cluster 2347096 cells

Cluster 1745891 cells

Cluster 141977 cells

Cluster 1938051 cells

Cluster 532723 cells

Cluster 1231321 cells

Cluster 1130613 cells

Cluster 3423246 cells

Cluster 215186 cells

Cluster 2013595 cells

Cluster 411774 cells

Cluster 368266 cells

Cluster 224063 cells

Cluster 462177 cells

Cluster 371951 cells

Cluster 42819 cells

Cluster 10606 cells

Cluster 6537 cells

Cluster 35189 cells

Cluster 33111 cells

Cluster 1443 cells

Cluster 4923 cells

Cluster 2116 cells

Cluster 4016 cells

Cluster 3912 cells

Cluster 169 cells

Cluster 307 cells

Cluster 384 cells

Cluster 243 cells

Cluster 473 cells

Cluster 433 cells

Cluster 283 cells

Cluster 02 cells

Cluster 452 cells

Cluster 501 cells

EasySci, single-nucleus909905 cells

flash-freeze in liquid nitrogen909905 cells

normal672673 cells

immuno-deficient237232 cells

C57BL/6672673 cells

B6.Cg-Prkdcscid/SzJ122806 cells

B6.129S7-Rag1tm1Mom/J114426 cells

6. Heart

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 10459269 cells

Cluster 15382421 cells

Cluster 3255334 cells

Cluster 12254935 cells

Cluster 7181829 cells

Cluster 16164458 cells

Cluster 17155654 cells

Cluster 1108100 cells

Cluster 1170123 cells

Cluster 1860082 cells

Cluster 1442566 cells

Cluster 2037532 cells

Cluster 627176 cells

Cluster 423971 cells

Cluster 1323594 cells

Cluster 223362 cells

Cluster 2121746 cells

Cluster 521656 cells

Cluster 918975 cells

Cluster 1918128 cells

Cluster 816973 cells

Cluster 2316591 cells

Cluster 2211695 cells

Cluster 249326 cells

WT1676957 cells

Rag415408 cells

Prkdc313131 cells

Male1223220 cells

Female1182276 cells

16 months582051 cells

3 months520070 cells

6 months455194 cells

12 months440427 cells

23 months407754 cells

Heart2405496 cells

Vascular endothelial cells919747 cells

Fibroblasts374218 cells

Ventricular cardiomyocytes336686 cells

Myeloid cells221527 cells

Mural cells182298 cells

Endocardial endothelial cells168871 cells

Lymphoid cells_T cells39374 cells

Lymphatic endothelial cells35964 cells

Atrial cardiomyocytes33768 cells

Lymphoid cells_B cells28822 cells

Mesothelial cells17840 cells

Neural cells15321 cells

Adipocytes11257 cells

Circulating hepatoblasts10781 cells

Brown adipocytes7347 cells

Colec10 positive cells662 cells

Myeloid cells_Mast cells380 cells

Fut9 positive cells377 cells

Alox15 positive cells256 cells

Endothelial1124582 cells

Stromal557178 cells

Muscle370454 cells

Immune290359 cells

Epithelial28621 cells

Adipose18604 cells

Neural15698 cells

Cluster 21438605 cells

Cluster 25381751 cells

Cluster 6378952 cells

Cluster 2285324 cells

Cluster 1279157 cells

Cluster 4151287 cells

Cluster 12116503 cells

Cluster 22114025 cells

Cluster 5103198 cells

Cluster 4562211 cells

Cluster 1721285 cells

Cluster 1116124 cells

Cluster 2316050 cells

Cluster 1912064 cells

Cluster 1011317 cells

Cluster 137413 cells

Cluster 244364 cells

Cluster 282814 cells

Cluster 31157 cells

Cluster 43677 cells

Cluster 33183 cells

Cluster 20173 cells

Cluster 39158 cells

Cluster 4295 cells

Cluster 3786 cells

Cluster 3583 cells

Cluster 060 cells

Cluster 1654 cells

Cluster 851 cells

Cluster 1839 cells

Cluster 1438 cells

Cluster 3837 cells

Cluster 3031 cells

Cluster 1523 cells

Cluster 4020 cells

Cluster 715 cells

Cluster 4411 cells

Cluster 910 cells

Cluster 4610 cells

Cluster 4710 cells

Cluster 296 cells

Cluster 276 cells

Cluster 495 cells

Cluster 325 cells

Cluster 414 cells

Cluster 262 cells

Cluster 511 cells

Cluster 311 cells

Cluster 361 cells

EasySci, single-nucleus2405496 cells

flash-freeze in liquid nitrogen2405496 cells

normal1676957 cells

immuno-deficient728539 cells

C57BL/61676957 cells

B6.129S7-Rag1tm1Mom/J415408 cells

B6.Cg-Prkdcscid/SzJ313131 cells

7. Ileum

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 22178661 cells

Cluster 25105878 cells

Cluster 189761 cells

Cluster 979382 cells

Cluster 1362497 cells

Cluster 1160985 cells

Cluster 2360730 cells

Cluster 454165 cells

Cluster 2452184 cells

Cluster 2148748 cells

Cluster 1842917 cells

Cluster 1637565 cells

Cluster 1532258 cells

Cluster 3230950 cells

Cluster 2626286 cells

Cluster 617984 cells

Cluster 1415002 cells

Cluster 3314928 cells

Cluster 513250 cells

Cluster 1912828 cells

Cluster 2812755 cells

Cluster 1012326 cells

Cluster 2711098 cells

Cluster 810910 cells

Cluster 710853 cells

Cluster 3110326 cells

Cluster 310188 cells

Cluster 29819 cells

Cluster 297804 cells

Cluster 126770 cells

Cluster 176156 cells

Cluster 365639 cells

Cluster 204804 cells

Cluster 303899 cells

Cluster 352652 cells

Cluster 341353 cells

WT1164311 cells

Female593670 cells

Male570641 cells

3 months265699 cells

23 months259984 cells

6 months229322 cells

12 months213286 cells

16 months196020 cells

Ileum1164311 cells

Intestinal epithelial cells393163 cells

Lymphoid cells_Resting B cells189489 cells

Lymphoid cells_T cells134428 cells

Paneth cells104912 cells

Fibroblasts76215 cells

Lymphoid cells_Cycling B cells52379 cells

Myeloid cells52092 cells

Goblet cells50540 cells

Lymphoid cells_Plasma cells43404 cells

Mural cells14754 cells

Lymphatic endothelial cells11842 cells

Myeloid cells_Dendritic cells11153 cells

Enteroendocrine cells7259 cells

Mfge8 positive cells6031 cells

Tuft cells5282 cells

Enteric glia2579 cells

Ngf positive cells2570 cells

Adipocytes2017 cells

Mesothelial cells1891 cells

Enteric neurons1704 cells

Myeloid cells_Mast cells607 cells

Epithelial563047 cells

Immune483552 cells

Stromal99570 cells

Endothelial11842 cells

Neural4283 cells

Adipose2017 cells

Cluster 11189793 cells

Cluster 9143911 cells

Cluster 26117057 cells

Cluster 1999260 cells

Cluster 1790939 cells

Cluster 778788 cells

Cluster 1576194 cells

Cluster 3675878 cells

Cluster 3468713 cells

Cluster 1244966 cells

Cluster 242080 cells

Cluster 2341942 cells

Cluster 141832 cells

Cluster 518976 cells

Cluster 412010 cells

Cluster 2210848 cells

Cluster 462882 cells

Cluster 101988 cells

Cluster 201944 cells

Cluster 61883 cells

Cluster 421188 cells

Cluster 37710 cells

Cluster 35236 cells

Cluster 49146 cells

Cluster 1448 cells

Cluster 3335 cells

Cluster 2132 cells

Cluster 3912 cells

Cluster 406 cells

Cluster 162 cells

Cluster 242 cells

Cluster 02 cells

Cluster 282 cells

Cluster 442 cells

Cluster 481 cells

Cluster 471 cells

Cluster 451 cells

Cluster 131 cells

EasySci, single-nucleus1164311 cells

flash-freeze in liquid nitrogen1164311 cells

normal1164311 cells

C57BL/61164311 cells

8. Jejunum

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 1149071 cells

Cluster 2296528 cells

Cluster 4795396 cells

Cluster 3287582 cells

Cluster 4473363 cells

Cluster 354284 cells

Cluster 1650800 cells

Cluster 3544957 cells

Cluster 2944396 cells

Cluster 3833153 cells

Cluster 3330868 cells

Cluster 3424511 cells

Cluster 3023692 cells

Cluster 3623110 cells

Cluster 722994 cells

Cluster 2419976 cells

Cluster 3719131 cells

Cluster 2517664 cells

Cluster 217578 cells

Cluster 4317054 cells

Cluster 2316437 cells

Cluster 5716216 cells

Cluster 4815487 cells

Cluster 3114234 cells

Cluster 4214122 cells

Cluster 2613866 cells

Cluster 2713799 cells

Cluster 1913677 cells

Cluster 613628 cells

Cluster 1513569 cells

Cluster 2013222 cells

Cluster 5613138 cells

Cluster 5512926 cells

Cluster 5212372 cells

Cluster 6011298 cells

Cluster 1111177 cells

Cluster 5310797 cells

Cluster 4510580 cells

Cluster 1010352 cells

Cluster 179908 cells

Cluster 139849 cells

Cluster 99847 cells

Cluster 59677 cells

Cluster 409641 cells

Cluster 289373 cells

Cluster 649143 cells

Cluster 148613 cells

Cluster 548564 cells

Cluster 188435 cells

Cluster 638260 cells

Cluster 87674 cells

Cluster 397273 cells

Cluster 687248 cells

Cluster 466566 cells

Cluster 495781 cells

Cluster 125585 cells

Cluster 655532 cells

Cluster 45150 cells

Cluster 504779 cells

Cluster 664218 cells

Cluster 673868 cells

Cluster 623687 cells

Cluster 593614 cells

Cluster 613565 cells

Cluster 413383 cells

Cluster 212471 cells

Cluster 582171 cells

Cluster 511282 cells

WT1008323 cells

Rag199411 cells

Prkdc174428 cells

Female692366 cells

Male689796 cells

3 months322582 cells

12 months282323 cells

23 months263492 cells

16 months262459 cells

6 months251306 cells

Jejunum1382162 cells

Intestinal epithelial cells693901 cells

Lymphoid cells_T cells148970 cells

Paneth cells98346 cells

Lymphoid cells_B cells96036 cells

Fibroblasts89810 cells

Myeloid cells73648 cells

Goblet cells59390 cells

Lymphoid cells_Plasma cells49163 cells

Myeloid cells_Dendritic cells19129 cells

Mural cells12317 cells

Lymphatic endothelial cells10611 cells

Enteroendocrine cells10109 cells

Tuft cells5530 cells

Mesothelial cells3811 cells

Mfge8 positive cells2156 cells

Enteric glia2085 cells

Ngf positive cells1949 cells

Adipocytes1706 cells

Enteric neurons1604 cells

Pde4c positive cells1258 cells

Myeloid cells_Mast cells633 cells

Epithelial871087 cells

Immune387579 cells

Stromal107490 cells

Endothelial10611 cells

Neural3689 cells

Adipose1706 cells

Cluster 9324777 cells

Cluster 7172153 cells

Cluster 26156932 cells

Cluster 15102994 cells

Cluster 1785184 cells

Cluster 1174270 cells

Cluster 3471396 cells

Cluster 1971242 cells

Cluster 2361927 cells

Cluster 154144 cells

Cluster 1253859 cells

Cluster 3645638 cells

Cluster 538715 cells

Cluster 229296 cells

Cluster 415159 cells

Cluster 228354 cells

Cluster 207725 cells

Cluster 462626 cells

Cluster 101660 cells

Cluster 371475 cells

Cluster 61068 cells

Cluster 421037 cells

Cluster 35271 cells

Cluster 3372 cells

Cluster 4952 cells

Cluster 1442 cells

Cluster 2123 cells

Cluster 3920 cells

Cluster 4010 cells

Cluster 438 cells

Cluster 476 cells

Cluster 05 cells

Cluster 245 cells

Cluster 383 cells

Cluster 133 cells

Cluster 282 cells

Cluster 302 cells

Cluster 32 cells

Cluster 162 cells

Cluster 312 cells

Cluster 81 cells

EasySci, single-nucleus1382162 cells

flash-freeze in liquid nitrogen1382162 cells

normal1008323 cells

immuno-deficient373839 cells

C57BL/61008323 cells

B6.129S7-Rag1tm1Mom/J199411 cells

B6.Cg-Prkdcscid/SzJ174428 cells

9. Kidney

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 24232784 cells

Cluster 19210754 cells

Cluster 33162833 cells

Cluster 1157304 cells

Cluster 2149874 cells

Cluster 3141220 cells

Cluster 16139209 cells

Cluster 7124644 cells

Cluster 12124571 cells

Cluster 25109452 cells

Cluster 14108617 cells

Cluster 1589194 cells

Cluster 2386097 cells

Cluster 1183884 cells

Cluster 2678067 cells

Cluster 566877 cells

Cluster 862323 cells

Cluster 3260533 cells

Cluster 1759786 cells

Cluster 1352518 cells

Cluster 3652493 cells

Cluster 2151167 cells

Cluster 2048837 cells

Cluster 2947677 cells

Cluster 643175 cells

Cluster 3442772 cells

Cluster 4040682 cells

Cluster 3838112 cells

Cluster 1037163 cells

Cluster 935928 cells

Cluster 434945 cells

Cluster 4134451 cells

Cluster 3534066 cells

Cluster 3131357 cells

Cluster 1830637 cells

Cluster 3728866 cells

Cluster 3020464 cells

Cluster 2817780 cells

Cluster 2715356 cells

Cluster 398432 cells

Cluster 426646 cells

Cluster 221303 cells

WT1919594 cells

Rag565033 cells

Prkdc518223 cells

Female1505660 cells

Male1497190 cells

3 months808690 cells

16 months775247 cells

12 months491065 cells

6 months475038 cells

23 months452810 cells

Kidney3002850 cells

Proximal tubule cells1969033 cells

Thick ascending limb of LOH cells227753 cells

Distal convoluted tubule cells223027 cells

Vascular endothelial cells156275 cells

Fibroblasts104316 cells

Connecting tubule cells45894 cells

Type B intercalated cells40606 cells

Type A intercalated cells38819 cells

Principal cells35476 cells

Myeloid cells29929 cells

Lymphoid cells_T cells24906 cells

Descending thin limb of LOH cells19739 cells

Ncam1 positive cells11850 cells

Lymphoid cells_B cells11474 cells

Myeloid cells_Dendritic cells9199 cells

Podocytes8835 cells

Juxtaglomerular cells8301 cells

Ascending thin limb of LOH cells8171 cells

Urothelial cells7173 cells

Megf11 positive cells6220 cells

Lgr5 positive cells5491 cells

Lymphoid cells_Plasma cells4738 cells

Macula densa cells3743 cells

Lymphatic endothelial cells1003 cells

Adipocytes879 cells

Epithelial2642790 cells

Endothelial162769 cells

Stromal116166 cells

Immune80246 cells

Adipose879 cells

Cluster 0907472 cells

Cluster 8640126 cells

Cluster 18446760 cells

Cluster 16378444 cells

Cluster 30283506 cells

Cluster 2287626 cells

Cluster 471272 cells

Cluster 255671 cells

Cluster 154135 cells

Cluster 1218881 cells

Cluster 515562 cells

Cluster 1711085 cells

Cluster 239654 cells

Cluster 116330 cells

Cluster 195991 cells

Cluster 63480 cells

Cluster 371685 cells

Cluster 511415 cells

Cluster 201273 cells

Cluster 10649 cells

Cluster 47496 cells

Cluster 33398 cells

Cluster 39220 cells

Cluster 28156 cells

Cluster 38128 cells

Cluster 40112 cells

Cluster 24107 cells

Cluster 5084 cells

Cluster 2139 cells

Cluster 4219 cells

Cluster 4913 cells

Cluster 3513 cells

Cluster 4812 cells

Cluster 1510 cells

Cluster 138 cells

Cluster 38 cells

Cluster 77 cells

Cluster 433 cells

EasySci, single-nucleus3002850 cells

flash-freeze in liquid nitrogen3002850 cells

normal1919594 cells

immuno-deficient1083256 cells

C57BL/61919594 cells

B6.129S7-Rag1tm1Mom/J565033 cells

B6.Cg-Prkdcscid/SzJ518223 cells

10. Liver

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 3362357 cells

Cluster 5258529 cells

Cluster 1199903 cells

Cluster 6190813 cells

Cluster 8155132 cells

Cluster 14128146 cells

Cluster 2124765 cells

Cluster 12122360 cells

Cluster 1397254 cells

Cluster 459996 cells

Cluster 955823 cells

Cluster 743427 cells

Cluster 1034553 cells

Cluster 1533192 cells

Cluster 1129059 cells

Cluster 175224 cells

Cluster 161555 cells

Cluster 18305 cells

WT1235246 cells

Rag336289 cells

Prkdc330858 cells

Female952763 cells

Male949630 cells

3 months645231 cells

16 months407055 cells

6 months386346 cells

23 months276357 cells

12 months187404 cells

Liver1902393 cells

Hepatocytes1476501 cells

Vascular endothelial cells137367 cells

Myeloid cells135576 cells

Hepatic stellate cells60347 cells

Lymphoid cells_B cells39242 cells

Lymphoid cells_T cells34550 cells

Cholangiocytes11669 cells

Cacna1b positive cells3339 cells

Mesothelial cells3036 cells

Adipocytes766 cells

Epithelial1494545 cells

Immune209368 cells

Endothelial137367 cells

Stromal60347 cells

Adipose766 cells

Cluster 3896537 cells

Cluster 13556382 cells

Cluster 12109811 cells

Cluster 22105926 cells

Cluster 4376207 cells

Cluster 245019 cells

Cluster 1126495 cells

Cluster 1722437 cells

Cluster 516446 cells

Cluster 416080 cells

Cluster 17643 cells

Cluster 377069 cells

Cluster 196991 cells

Cluster 235534 cells

Cluster 20791 cells

Cluster 10573 cells

Cluster 6402 cells

Cluster 16389 cells

Cluster 0325 cells

Cluster 39275 cells

Cluster 33244 cells

Cluster 24226 cells

Cluster 15153 cells

Cluster 2785 cells

Cluster 1866 cells

Cluster 3061 cells

Cluster 4243 cells

Cluster 2833 cells

Cluster 731 cells

Cluster 823 cells

Cluster 3820 cells

Cluster 4015 cells

Cluster 5012 cells

Cluster 4911 cells

Cluster 3511 cells

Cluster 4610 cells

Cluster 478 cells

Cluster 214 cells

Cluster 363 cells

Cluster 481 cells

Cluster 261 cells

EasySci, single-nucleus1902393 cells

flash-freeze in liquid nitrogen1902393 cells

normal1235246 cells

immuno-deficient667147 cells

C57BL/61235246 cells

B6.129S7-Rag1tm1Mom/J336289 cells

B6.Cg-Prkdcscid/SzJ330858 cells

11. Lung

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 8312106 cells

Cluster 13277358 cells

Cluster 20201208 cells

Cluster 10198919 cells

Cluster 2184994 cells

Cluster 6159318 cells

Cluster 12144967 cells

Cluster 4137162 cells

Cluster 2693969 cells

Cluster 1886460 cells

Cluster 2583654 cells

Cluster 1163907 cells

Cluster 162850 cells

Cluster 757425 cells

Cluster 1457211 cells

Cluster 2456686 cells

Cluster 945653 cells

Cluster 1541003 cells

Cluster 2335468 cells

Cluster 1628551 cells

Cluster 1728256 cells

Cluster 525965 cells

Cluster 3019898 cells

Cluster 2116782 cells

Cluster 3116680 cells

Cluster 2816354 cells

Cluster 3214796 cells

Cluster 314359 cells

Cluster 2214189 cells

Cluster 2914131 cells

Cluster 1911467 cells

Cluster 2711263 cells

Cluster 344316 cells

Cluster 354169 cells

Cluster 333439 cells

WT1740415 cells

Prkdc466475 cells

Rag338043 cells

Male1276042 cells

Female1268891 cells

3 months782246 cells

16 months465406 cells

12 months443285 cells

6 months442657 cells

23 months411339 cells

Lung2544933 cells

Type II alveolar epithelial cells627546 cells

Vascular endothelial cells_General capillary cells344538 cells

Lymphoid cells_B cells225326 cells

Myeloid cells_Alveolar macrophages218710 cells

Lymphoid cells_T cells203859 cells

Secretory cells197313 cells

Type I alveolar epithelial cells156983 cells

Myeloid cells_Monocytes128240 cells

Fibroblasts107370 cells

Vascular endothelial cells_Aerocytes95824 cells

Mural cells61127 cells

Myeloid cells_Dendritic cells45382 cells

Myeloid cells_Neutrophils44606 cells

Lymphoid cells_Plasma cells20320 cells

Myeloid cells_Interstitial macrophages19380 cells

Ciliated cells17425 cells

Mesothelial cells10739 cells

Lymphatic endothelial cells6758 cells

Adipocytes5137 cells

Myeloid cells_Basophils3126 cells

Pulmonary neuroendocrine cells2656 cells

Basal cells2568 cells

Epithelial1015230 cells

Immune908949 cells

Endothelial447120 cells

Stromal168497 cells

Adipose5137 cells

Cluster 5352339 cells

Cluster 29341926 cells

Cluster 32309089 cells

Cluster 33302463 cells

Cluster 38204058 cells

Cluster 39174455 cells

Cluster 40143013 cells

Cluster 19124175 cells

Cluster 23106390 cells

Cluster 12103860 cells

Cluster 11103463 cells

Cluster 193637 cells

Cluster 1778658 cells

Cluster 255122 cells

Cluster 4821827 cells

Cluster 410753 cells

Cluster 226874 cells

Cluster 104667 cells

Cluster 202330 cells

Cluster 462129 cells

Cluster 371903 cells

Cluster 6234 cells

Cluster 25230 cells

Cluster 15179 cells

Cluster 13163 cells

Cluster 42147 cells

Cluster 35126 cells

Cluster 3093 cells

Cluster 783 cells

Cluster 2782 cells

Cluster 382 cells

Cluster 2178 cells

Cluster 1665 cells

Cluster 4365 cells

Cluster 4953 cells

Cluster 2851 cells

Cluster 2434 cells

Cluster 456 cells

Cluster 86 cells

Cluster 185 cells

Cluster 05 cells

Cluster 504 cells

Cluster 474 cells

Cluster 144 cells

Cluster 442 cells

Cluster 91 cells

EasySci, single-nucleus2544933 cells

flash-freeze in liquid nitrogen2544933 cells

normal1740415 cells

immuno-deficient804518 cells

C57BL/61740415 cells

B6.Cg-Prkdcscid/SzJ466475 cells

B6.129S7-Rag1tm1Mom/J338043 cells

12. Muscle

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Sample ID

Disease

Mouse strand

Cluster 2112477 cells

Cluster 890275 cells

Cluster 1583424 cells

Cluster 1775196 cells

Cluster 152723 cells

Cluster 1445529 cells

Cluster 642820 cells

Cluster 929537 cells

Cluster 426872 cells

Cluster 2022663 cells

Cluster 1118995 cells

Cluster 1215481 cells

Cluster 1010692 cells

Cluster 229342 cells

Cluster 219240 cells

Cluster 168914 cells

Cluster 78774 cells

Cluster 137740 cells

Cluster 197392 cells

Cluster 37386 cells

Cluster 55713 cells

Cluster 185225 cells

WT468980 cells

Rag113804 cells

Prkdc113626 cells

Male373401 cells

Female323009 cells

3 months177440 cells

16 months167407 cells

6 months123664 cells

23 months120445 cells

12 months107454 cells

Muscle696410 cells

Type II myonuclei317825 cells

Vascular endothelial cells116583 cells

Fibro–adipogenic progenitors83177 cells

Mural cells54405 cells

Myeloid cells30431 cells

Adipocytes29714 cells

Muscle satellite cells10504 cells

Myotendinous junction myonuclei8441 cells

Tenocytes8163 cells

Myelinating Schwann cells8112 cells

Lymphoid cells6992 cells

Type I myonuclei6916 cells

Lymphatic endothelial cells4896 cells

Non-myelinating Schwann cells2388 cells

Asic2 positive cells2285 cells

Neuromuscular junction myonuclei1563 cells

Erythroblasts1470 cells

Circulating hepatoblasts1207 cells

Myeloid cells_Mast cells1043 cells

Mirg positive cells289 cells

Osteoblasts6 cells

Muscle345538 cells

Stromal148036 cells

Endothelial121479 cells

Immune39936 cells

Adipose29714 cells

Neural10500 cells

Epithelial1207 cells

Cluster 27341156 cells

Cluster 299124 cells

Cluster 669947 cells

Cluster 158105 cells

Cluster 448543 cells

Cluster 1029443 cells

Cluster 1217714 cells

Cluster 512481 cells

Cluster 2210578 cells

Cluster 172599 cells

Cluster 112031 cells

Cluster 191179 cells

Cluster 23969 cells

Cluster 21563 cells

Cluster 3543 cells

Cluster 13408 cells

Cluster 43220 cells

Cluster 24167 cells

Cluster 37161 cells

Cluster 20128 cells

Cluster 3589 cells

Cluster 2871 cells

Cluster 4240 cells

Cluster 1526 cells

Cluster 4924 cells

Cluster 1615 cells

Cluster 4514 cells

Cluster 3312 cells

Cluster 409 cells

Cluster 148 cells

Cluster 77 cells

Cluster 06 cells

Cluster 184 cells

Cluster 394 cells

Cluster 93 cells

Cluster 383 cells

Cluster 293 cells

Cluster 303 cells

Cluster 412 cells

Cluster 472 cells

Cluster 462 cells

Cluster 322 cells

Cluster 81 cells

Cluster 311 cells

EasySci, single-nucleus696410 cells

flash-freeze in liquid nitrogen696410 cells

20230218_EXP103_768783 cells

20230218_EXP103_758632 cells

20230218_EXP103_078597 cells

20230218_EXP103_618576 cells

20230218_EXP103_778482 cells

20230218_EXP103_038481 cells

20230218_EXP103_058451 cells

20230218_EXP103_238395 cells

20230218_EXP103_788370 cells

20230218_EXP103_748370 cells

20230218_EXP103_798346 cells

20230218_EXP103_478345 cells

20230218_EXP103_838338 cells

20230218_EXP103_068290 cells

20230218_EXP103_518227 cells

20230218_EXP103_408206 cells

20230218_EXP103_398206 cells

20230218_EXP103_558203 cells

20230218_EXP103_448177 cells

20230218_EXP103_858153 cells

20230218_EXP103_218126 cells

20230218_EXP103_488097 cells

20230218_EXP103_338080 cells

20230218_EXP103_228061 cells

20230218_EXP103_548056 cells

20230218_EXP103_808032 cells

20230218_EXP103_048031 cells

20230218_EXP103_608026 cells

20230218_EXP103_868017 cells

20230218_EXP103_357997 cells

20230218_EXP103_247996 cells

20230218_EXP103_717979 cells

20230218_EXP103_627961 cells

20230218_EXP103_847938 cells

20230218_EXP103_437936 cells

20230218_EXP103_207933 cells

20230218_EXP103_387922 cells

20230218_EXP103_687861 cells

20230218_EXP103_827816 cells

20230218_EXP103_567810 cells

20230218_EXP103_087796 cells

20230218_EXP103_697788 cells

20230218_EXP103_877785 cells

20230218_EXP103_427755 cells

20230218_EXP103_347739 cells

20230218_EXP103_507707 cells

20230218_EXP103_317704 cells

20230218_EXP103_527685 cells

20230218_EXP103_367685 cells

20230218_EXP103_197673 cells

20230218_EXP103_307667 cells

20230218_EXP103_647667 cells

20230218_EXP103_277627 cells

20230218_EXP103_177615 cells

20230218_EXP103_377576 cells

20230218_EXP103_327561 cells

20230218_EXP103_297539 cells

20230218_EXP103_637539 cells

20230218_EXP103_897524 cells

20230218_EXP103_467517 cells

20230218_EXP103_907466 cells

20230218_EXP103_537457 cells

20230218_EXP103_457451 cells

20230218_EXP103_737442 cells

20230218_EXP103_257424 cells

20230218_EXP103_707384 cells

20230218_EXP103_267298 cells

20230218_EXP103_597259 cells

20230218_EXP103_677256 cells

20230218_EXP103_817139 cells

20230218_EXP103_957133 cells

20230218_EXP103_187129 cells

20230218_EXP103_667079 cells

20230218_EXP103_927078 cells

20230218_EXP103_157071 cells

20230218_EXP103_657018 cells

20230218_EXP103_937003 cells

20230218_EXP103_126881 cells

20230218_EXP103_726878 cells

20230218_EXP103_916870 cells

20230218_EXP103_136804 cells

20230218_EXP103_106802 cells

20230218_EXP103_096657 cells

20230218_EXP103_496647 cells

20230218_EXP103_116585 cells

20230218_EXP103_146511 cells

20230218_EXP103_576163 cells

20230218_EXP103_286110 cells

20230218_EXP103_885493 cells

20230218_EXP103_945284 cells

20230218_EXP103_414467 cells

20230218_EXP103_163810 cells

20230218_EXP103_96455 cells

20230218_EXP103_58454 cells

normal468980 cells

immuno-deficient227430 cells

C57BL/6468980 cells

B6.129S7-Rag1tm1Mom/J113804 cells

B6.Cg-Prkdcscid/SzJ113626 cells

13. Stomach

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 466847 cells

Cluster 164250 cells

Cluster 2361362 cells

Cluster 2548633 cells

Cluster 1744284 cells

Cluster 2143847 cells

Cluster 1539112 cells

Cluster 937296 cells

Cluster 4832943 cells

Cluster 3932700 cells

Cluster 3724976 cells

Cluster 1022570 cells

Cluster 5620674 cells

Cluster 4519832 cells

Cluster 1119288 cells

Cluster 1217258 cells

Cluster 3217233 cells

Cluster 6015097 cells

Cluster 4614773 cells

Cluster 5114494 cells

Cluster 4414400 cells

Cluster 1412706 cells

Cluster 1312152 cells

Cluster 3011929 cells

Cluster 6311927 cells

Cluster 2911376 cells

Cluster 6111168 cells

Cluster 2411012 cells

Cluster 2210983 cells

Cluster 4910811 cells

Cluster 2610763 cells

Cluster 1810640 cells

Cluster 3310257 cells

Cluster 5710183 cells

Cluster 69852 cells

Cluster 209775 cells

Cluster 279755 cells

Cluster 429543 cells

Cluster 359502 cells

Cluster 289287 cells

Cluster 419083 cells

Cluster 78764 cells

Cluster 317870 cells

Cluster 647577 cells

Cluster 87540 cells

Cluster 57270 cells

Cluster 556992 cells

Cluster 656841 cells

Cluster 536490 cells

Cluster 476195 cells

Cluster 26191 cells

Cluster 366026 cells

Cluster 625796 cells

Cluster 545590 cells

Cluster 584869 cells

Cluster 384792 cells

Cluster 164597 cells

Cluster 194566 cells

Cluster 34418 cells

Cluster 433945 cells

Cluster 663722 cells

Cluster 593593 cells

Cluster 523590 cells

Cluster 673323 cells

Cluster 503009 cells

Cluster 401999 cells

Cluster 681559 cells

Cluster 341298 cells

WT687475 cells

Rag188231 cells

Prkdc147289 cells

Male530209 cells

Female492786 cells

16 months287028 cells

3 months270293 cells

12 months189261 cells

23 months159078 cells

6 months117335 cells

Stomach1022995 cells

Gastric mucous cells286070 cells

Chief cells225113 cells

Fibroblasts101996 cells

Gastric epithelial cells88422 cells

Parietal cells72637 cells

Mural cells54160 cells

Vascular endothelial cells47932 cells

Enteroendocrine cells44919 cells

Myeloid cells40608 cells

Lymphoid cells24495 cells

Lymphatic endothelial cells7114 cells

Enteric glia6058 cells

Sis positive cells4468 cells

Adipocytes4339 cells

Mesothelial cells4299 cells

Interstitial cells of Cajal3563 cells

Skeletal muscle cells3540 cells

Enteric neurons1837 cells

Tuft cells1425 cells

Epithelial727353 cells

Stromal156156 cells

Immune65103 cells

Endothelial55046 cells

Neural7895 cells

Muscle7103 cells

Adipose4339 cells

Cluster 20420697 cells

Cluster 37235316 cells

Cluster 1109570 cells

Cluster 263577 cells

Cluster 4640937 cells

Cluster 431518 cells

Cluster 524788 cells

Cluster 1520937 cells

Cluster 1215741 cells

Cluster 2212403 cells

Cluster 239502 cells

Cluster 67766 cells

Cluster 176658 cells

Cluster 76191 cells

Cluster 103966 cells

Cluster 193295 cells

Cluster 112107 cells

Cluster 271632 cells

Cluster 421401 cells

Cluster 36755 cells

Cluster 34743 cells

Cluster 9711 cells

Cluster 26565 cells

Cluster 16509 cells

Cluster 35374 cells

Cluster 30227 cells

Cluster 38213 cells

Cluster 40164 cells

Cluster 21134 cells

Cluster 43117 cells

Cluster 389 cells

Cluster 2883 cells

Cluster 3368 cells

Cluster 1460 cells

Cluster 2452 cells

Cluster 4732 cells

Cluster 4932 cells

Cluster 3916 cells

Cluster 1315 cells

Cluster 012 cells

Cluster 507 cells

Cluster 324 cells

Cluster 84 cells

Cluster 453 cells

Cluster 482 cells

Cluster 441 cells

Cluster 181 cells

EasySci, single-nucleus1022995 cells

flash-freeze in liquid nitrogen1022995 cells

normal687475 cells

immuno-deficient335520 cells

C57BL/6687475 cells

B6.129S7-Rag1tm1Mom/J188231 cells

B6.Cg-Prkdcscid/SzJ147289 cells

14. Brain

Explore

Leiden clustering

Genotype

Sex

Age

Tissue

Cell type

Cell lineage

Louvain clustering (All cells)

Assay

Sample preservation method

Disease

Mouse strand

Cluster 1381375 cells

Cluster 2172295 cells

Cluster 6146025 cells

Cluster 4105743 cells

Cluster 15104121 cells

Cluster 565902 cells

Cluster 1964444 cells

Cluster 761249 cells

Cluster 1152030 cells

Cluster 1037052 cells

Cluster 2332050 cells

Cluster 830406 cells

Cluster 1427669 cells

Cluster 1322019 cells

Cluster 2020505 cells

Cluster 2520197 cells

Cluster 914771 cells

Cluster 1714356 cells

Cluster 313978 cells

Cluster 2210276 cells

Cluster 289089 cells

Cluster 128388 cells

Cluster 297519 cells

Cluster 307124 cells

Cluster 216580 cells

Cluster 326235 cells

Cluster 264399 cells

Cluster 344168 cells

Cluster 333468 cells

Cluster 242840 cells

Cluster 182699 cells

Cluster 372065 cells

Cluster 271960 cells

Cluster 381790 cells

Cluster 311734 cells

Cluster 36816 cells

Cluster 35784 cells

Cluster 16712 cells

Cluster 39278 cells

WT918396 cells

APOE375042 cells

5xFAD175673 cells

Male768585 cells

Female700526 cells

3 months905557 cells

6 months306537 cells

21 months257017 cells

Brain1469111 cells

Cerebellum granule neurons477790 cells

Cortical projection neurons 1177274 cells

Interbrain and midbrain neurons 1154645 cells

Interbrain and midbrain neurons 2143349 cells

Oligodendrocytes104514 cells

Astrocytes66383 cells

Striatal neurons 156080 cells

Cortical projection neurons 239036 cells

OB neurons 137258 cells

Cerebellum interneurons27566 cells

Interneurons 127475 cells

Oligodendrocyte progenitor cells22718 cells

Endothelial cells20362 cells

Dentate gyrus neurons20110 cells

Microglia16879 cells

Interneurons 216370 cells

Purkinje neurons10439 cells

Bergmann glia9478 cells

Vascular leptomeningeal cells8277 cells

OB neurons 26823 cells

Choroid plexus epithelial cells4379 cells

Cortical projection neurons 34219 cells

Hindbrain neurons 23181 cells

Ependymal cells3049 cells

OB neurons 32539 cells

Striatal neurons 22079 cells

Hindbrain neurons 11854 cells

Habenula neurons1541 cells

Pituitary cells1365 cells

Unipolar brush cells1296 cells

Inferior olivary nucleus neurons783 cells

Neural1416165 cells

Endothelial20362 cells

Immune16879 cells

Stromal8277 cells

Epithelial7428 cells

Cluster 14553574 cells

Cluster 31329157 cells

Cluster 35288876 cells

Cluster 41123287 cells

Cluster 4279650 cells

Cluster 4471124 cells

Cluster 4914962 cells

Cluster 12714 cells

Cluster 22243 cells

Cluster 41060 cells

Cluster 12795 cells

Cluster 22671 cells

Cluster 46321 cells

Cluster 5295 cells

Cluster 6114 cells

Cluster 1771 cells

Cluster 1943 cells

Cluster 2340 cells

Cluster 1129 cells

Cluster 2024 cells

Cluster 3715 cells

Cluster 2115 cells

Cluster 1610 cells

Cluster 74 cells

Cluster 304 cells

Cluster 284 cells

Cluster 152 cells

Cluster 332 cells

Cluster 471 cells

Cluster 431 cells

Cluster 391 cells

Cluster 271 cells

Cluster 251 cells

EasySci, single-nucleus1469111 cells

flash-freeze in liquid nitrogen1469111 cells

normal1469111 cells

C57BL/61469111 cells