A panoramic view of cell population dynamics in mammalian aging

Cite

Zhang, Z., Schaefer, C., Jiang, W., Lu, Z., Lee, J., Sziraki, A., Abdulraouf, A., Wick, B., Haeussler, M., Li, Z. and Molla, G., 2024. A panoramic view of cell population dynamics in mammalian aging. Science, 387(6731), p.eadn3949.

https://doi.org/10.1126/science.adn3949

Abstract

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.

Datasets

1. Inguinal white adipose tissue

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 2154,964 cells
Cluster 3101,191 cells
Cluster 1043,277 cells
Cluster 839,178 cells
Cluster 1235,145 cells
Cluster 1434,423 cells
Cluster 3127,978 cells
Cluster 2826,673 cells
Cluster 2622,771 cells
Cluster 2221,123 cells
Cluster 2521,105 cells
Cluster 2920,440 cells
Cluster 2720,360 cells
Cluster 1820,355 cells
Cluster 2420,334 cells
Cluster 119,391 cells
Cluster 1718,253 cells
Cluster 3417,598 cells
Cluster 3217,571 cells
Cluster 3614,543 cells
Cluster 2313,771 cells
Cluster 1113,069 cells
Cluster 3012,759 cells
Cluster 512,033 cells
Cluster 411,934 cells
Cluster 1310,609 cells
Cluster 3310,363 cells
Cluster 2110,087 cells
Cluster 199,564 cells
Cluster 69,535 cells
Cluster 169,238 cells
Cluster 378,372 cells
Cluster 158,054 cells
Cluster 356,781 cells
Cluster 96,633 cells
Cluster 404,350 cells
Cluster 394,013 cells
Cluster 202,167 cells
Cluster 38650 cells
Cluster 7461 cells
A panoramic view of cell population dynamics in mammalian aging

2. Brown adipose tissue

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 11286,454 cells
Cluster 21206,168 cells
Cluster 10188,372 cells
Cluster 2681,893 cells
Cluster 565,001 cells
Cluster 1654,736 cells
Cluster 1548,356 cells
Cluster 646,303 cells
Cluster 1240,331 cells
Cluster 133,097 cells
Cluster 1432,390 cells
Cluster 1331,199 cells
Cluster 2329,955 cells
Cluster 2429,341 cells
Cluster 1929,318 cells
Cluster 427,194 cells
Cluster 327,167 cells
Cluster 225,614 cells
Cluster 1823,132 cells
Cluster 2220,900 cells
Cluster 818,707 cells
Cluster 2716,881 cells
Cluster 2514,972 cells
Cluster 2013,555 cells
Cluster 1712,802 cells
Cluster 79,578 cells
Cluster 282,817 cells
Cluster 292,426 cells
Cluster 91,170 cells
Cluster 30994 cells
Cluster 31515 cells
A panoramic view of cell population dynamics in mammalian aging

3. Perigonadal white adipose tissue

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 10139,116 cells
Cluster 15120,300 cells
Cluster 14108,372 cells
Cluster 13102,617 cells
Cluster 378,192 cells
Cluster 261,587 cells
Cluster 150,731 cells
Cluster 948,384 cells
Cluster 643,774 cells
Cluster 743,296 cells
Cluster 1640,730 cells
Cluster 527,611 cells
Cluster 416,437 cells
Cluster 814,761 cells
Cluster 1913,290 cells
Cluster 119,629 cells
Cluster 188,568 cells
Cluster 206,195 cells
Cluster 173,979 cells
Cluster 121,283 cells
A panoramic view of cell population dynamics in mammalian aging

4. Colon

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 1495,143 cells
Cluster 1576,931 cells
Cluster 3175,259 cells
Cluster 2470,812 cells
Cluster 468,157 cells
Cluster 2063,864 cells
Cluster 762,768 cells
Cluster 1960,624 cells
Cluster 3954,137 cells
Cluster 1045,317 cells
Cluster 1243,899 cells
Cluster 2140,516 cells
Cluster 4333,640 cells
Cluster 2732,735 cells
Cluster 1632,699 cells
Cluster 2232,403 cells
Cluster 2331,757 cells
Cluster 930,822 cells
Cluster 125,985 cells
Cluster 4518,325 cells
Cluster 2516,932 cells
Cluster 616,044 cells
Cluster 2915,462 cells
Cluster 1815,354 cells
Cluster 3814,677 cells
Cluster 1314,652 cells
Cluster 3413,999 cells
Cluster 1713,667 cells
Cluster 3013,254 cells
Cluster 1113,227 cells
Cluster 4213,216 cells
Cluster 4010,908 cells
Cluster 369,040 cells
Cluster 328,644 cells
Cluster 538,302 cells
Cluster 488,120 cells
Cluster 497,740 cells
Cluster 27,355 cells
Cluster 517,306 cells
Cluster 446,618 cells
Cluster 356,178 cells
Cluster 286,163 cells
Cluster 85,457 cells
Cluster 415,450 cells
Cluster 525,029 cells
Cluster 375,002 cells
Cluster 564,873 cells
Cluster 334,689 cells
Cluster 504,501 cells
Cluster 544,185 cells
Cluster 263,867 cells
Cluster 53,730 cells
Cluster 33,073 cells
Cluster 463,008 cells
Cluster 472,630 cells
Cluster 552,051 cells
A panoramic view of cell population dynamics in mammalian aging

5. Duodenum

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 191,844 cells
Cluster 554,613 cells
Cluster 2850,812 cells
Cluster 4447,140 cells
Cluster 246,382 cells
Cluster 3635,765 cells
Cluster 1634,307 cells
Cluster 3825,297 cells
Cluster 322,749 cells
Cluster 4520,106 cells
Cluster 3419,676 cells
Cluster 619,426 cells
Cluster 2416,115 cells
Cluster 914,369 cells
Cluster 4113,808 cells
Cluster 412,783 cells
Cluster 2912,474 cells
Cluster 811,840 cells
Cluster 2511,354 cells
Cluster 2311,262 cells
Cluster 7211,115 cells
Cluster 5410,951 cells
Cluster 4710,588 cells
Cluster 1110,476 cells
Cluster 1410,365 cells
Cluster 2610,203 cells
Cluster 3210,061 cells
Cluster 359,516 cells
Cluster 209,357 cells
Cluster 379,146 cells
Cluster 468,653 cells
Cluster 188,558 cells
Cluster 628,426 cells
Cluster 398,175 cells
Cluster 438,104 cells
Cluster 487,721 cells
Cluster 507,487 cells
Cluster 177,293 cells
Cluster 587,160 cells
Cluster 317,093 cells
Cluster 536,906 cells
Cluster 426,648 cells
Cluster 566,255 cells
Cluster 516,048 cells
Cluster 525,928 cells
Cluster 495,857 cells
Cluster 135,839 cells
Cluster 615,837 cells
Cluster 675,578 cells
Cluster 215,571 cells
Cluster 575,452 cells
Cluster 405,199 cells
Cluster 715,160 cells
Cluster 195,104 cells
Cluster 555,051 cells
Cluster 604,985 cells
Cluster 734,967 cells
Cluster 634,904 cells
Cluster 104,842 cells
Cluster 664,761 cells
Cluster 684,720 cells
Cluster 274,675 cells
Cluster 744,646 cells
Cluster 334,526 cells
Cluster 304,420 cells
Cluster 693,957 cells
Cluster 73,760 cells
Cluster 123,554 cells
Cluster 653,270 cells
Cluster 703,148 cells
Cluster 222,194 cells
Cluster 641,561 cells
Cluster 591,192 cells
Cluster 15820 cells
A panoramic view of cell population dynamics in mammalian aging

6. Heart

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 10459,269 cells
Cluster 15382,421 cells
Cluster 3255,334 cells
Cluster 12254,935 cells
Cluster 7181,829 cells
Cluster 16164,458 cells
Cluster 17155,654 cells
Cluster 1108,100 cells
Cluster 1170,123 cells
Cluster 1860,082 cells
Cluster 1442,566 cells
Cluster 2037,532 cells
Cluster 627,176 cells
Cluster 423,971 cells
Cluster 1323,594 cells
Cluster 223,362 cells
Cluster 2121,746 cells
Cluster 521,656 cells
Cluster 918,975 cells
Cluster 1918,128 cells
Cluster 816,973 cells
Cluster 2316,591 cells
Cluster 2211,695 cells
Cluster 249,326 cells
A panoramic view of cell population dynamics in mammalian aging

7. Ileum

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 22178,661 cells
Cluster 25105,878 cells
Cluster 189,761 cells
Cluster 979,382 cells
Cluster 1362,497 cells
Cluster 1160,985 cells
Cluster 2360,730 cells
Cluster 454,165 cells
Cluster 2452,184 cells
Cluster 2148,748 cells
Cluster 1842,917 cells
Cluster 1637,565 cells
Cluster 1532,258 cells
Cluster 3230,950 cells
Cluster 2626,286 cells
Cluster 617,984 cells
Cluster 1415,002 cells
Cluster 3314,928 cells
Cluster 513,250 cells
Cluster 1912,828 cells
Cluster 2812,755 cells
Cluster 1012,326 cells
Cluster 2711,098 cells
Cluster 810,910 cells
Cluster 710,853 cells
Cluster 3110,326 cells
Cluster 310,188 cells
Cluster 29,819 cells
Cluster 297,804 cells
Cluster 126,770 cells
Cluster 176,156 cells
Cluster 365,639 cells
Cluster 204,804 cells
Cluster 303,899 cells
Cluster 352,652 cells
Cluster 341,353 cells
A panoramic view of cell population dynamics in mammalian aging

8. Jejunum

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 1149,071 cells
Cluster 2296,528 cells
Cluster 4795,396 cells
Cluster 3287,582 cells
Cluster 4473,363 cells
Cluster 354,284 cells
Cluster 1650,800 cells
Cluster 3544,957 cells
Cluster 2944,396 cells
Cluster 3833,153 cells
Cluster 3330,868 cells
Cluster 3424,511 cells
Cluster 3023,692 cells
Cluster 3623,110 cells
Cluster 722,994 cells
Cluster 2419,976 cells
Cluster 3719,131 cells
Cluster 2517,664 cells
Cluster 217,578 cells
Cluster 4317,054 cells
Cluster 2316,437 cells
Cluster 5716,216 cells
Cluster 4815,487 cells
Cluster 3114,234 cells
Cluster 4214,122 cells
Cluster 2613,866 cells
Cluster 2713,799 cells
Cluster 1913,677 cells
Cluster 613,628 cells
Cluster 1513,569 cells
Cluster 2013,222 cells
Cluster 5613,138 cells
Cluster 5512,926 cells
Cluster 5212,372 cells
Cluster 6011,298 cells
Cluster 1111,177 cells
Cluster 5310,797 cells
Cluster 4510,580 cells
Cluster 1010,352 cells
Cluster 179,908 cells
Cluster 139,849 cells
Cluster 99,847 cells
Cluster 59,677 cells
Cluster 409,641 cells
Cluster 289,373 cells
Cluster 649,143 cells
Cluster 148,613 cells
Cluster 548,564 cells
Cluster 188,435 cells
Cluster 638,260 cells
Cluster 87,674 cells
Cluster 397,273 cells
Cluster 687,248 cells
Cluster 466,566 cells
Cluster 495,781 cells
Cluster 125,585 cells
Cluster 655,532 cells
Cluster 45,150 cells
Cluster 504,779 cells
Cluster 664,218 cells
Cluster 673,868 cells
Cluster 623,687 cells
Cluster 593,614 cells
Cluster 613,565 cells
Cluster 413,383 cells
Cluster 212,471 cells
Cluster 582,171 cells
Cluster 511,282 cells
A panoramic view of cell population dynamics in mammalian aging

9. Kidney

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 24232,784 cells
Cluster 19210,754 cells
Cluster 33162,833 cells
Cluster 1157,304 cells
Cluster 2149,874 cells
Cluster 3141,220 cells
Cluster 16139,209 cells
Cluster 7124,644 cells
Cluster 12124,571 cells
Cluster 25109,452 cells
Cluster 14108,617 cells
Cluster 1589,194 cells
Cluster 2386,097 cells
Cluster 1183,884 cells
Cluster 2678,067 cells
Cluster 566,877 cells
Cluster 862,323 cells
Cluster 3260,533 cells
Cluster 1759,786 cells
Cluster 1352,518 cells
Cluster 3652,493 cells
Cluster 2151,167 cells
Cluster 2048,837 cells
Cluster 2947,677 cells
Cluster 643,175 cells
Cluster 3442,772 cells
Cluster 4040,682 cells
Cluster 3838,112 cells
Cluster 1037,163 cells
Cluster 935,928 cells
Cluster 434,945 cells
Cluster 4134,451 cells
Cluster 3534,066 cells
Cluster 3131,357 cells
Cluster 1830,637 cells
Cluster 3728,866 cells
Cluster 3020,464 cells
Cluster 2817,780 cells
Cluster 2715,356 cells
Cluster 398,432 cells
Cluster 426,646 cells
Cluster 221,303 cells
A panoramic view of cell population dynamics in mammalian aging

10. Liver

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 3362,357 cells
Cluster 5258,529 cells
Cluster 1199,903 cells
Cluster 6190,813 cells
Cluster 8155,132 cells
Cluster 14128,146 cells
Cluster 2124,765 cells
Cluster 12122,360 cells
Cluster 1397,254 cells
Cluster 459,996 cells
Cluster 955,823 cells
Cluster 743,427 cells
Cluster 1034,553 cells
Cluster 1533,192 cells
Cluster 1129,059 cells
Cluster 175,224 cells
Cluster 161,555 cells
Cluster 18305 cells
A panoramic view of cell population dynamics in mammalian aging

11. Lung

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 8312,106 cells
Cluster 13277,358 cells
Cluster 20201,208 cells
Cluster 10198,919 cells
Cluster 2184,994 cells
Cluster 6159,318 cells
Cluster 12144,967 cells
Cluster 4137,162 cells
Cluster 2693,969 cells
Cluster 1886,460 cells
Cluster 2583,654 cells
Cluster 1163,907 cells
Cluster 162,850 cells
Cluster 757,425 cells
Cluster 1457,211 cells
Cluster 2456,686 cells
Cluster 945,653 cells
Cluster 1541,003 cells
Cluster 2335,468 cells
Cluster 1628,551 cells
Cluster 1728,256 cells
Cluster 525,965 cells
Cluster 3019,898 cells
Cluster 2116,782 cells
Cluster 3116,680 cells
Cluster 2816,354 cells
Cluster 3214,796 cells
Cluster 314,359 cells
Cluster 2214,189 cells
Cluster 2914,131 cells
Cluster 1911,467 cells
Cluster 2711,263 cells
Cluster 344,316 cells
Cluster 354,169 cells
Cluster 333,439 cells
A panoramic view of cell population dynamics in mammalian aging

12. Muscle

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 2112,477 cells
Cluster 890,275 cells
Cluster 1583,424 cells
Cluster 1775,196 cells
Cluster 152,723 cells
Cluster 1445,529 cells
Cluster 642,820 cells
Cluster 929,537 cells
Cluster 426,872 cells
Cluster 2022,663 cells
Cluster 1118,995 cells
Cluster 1215,481 cells
Cluster 1010,692 cells
Cluster 229,342 cells
Cluster 219,240 cells
Cluster 168,914 cells
Cluster 78,774 cells
Cluster 137,740 cells
Cluster 197,392 cells
Cluster 37,386 cells
Cluster 55,713 cells
Cluster 185,225 cells
A panoramic view of cell population dynamics in mammalian aging

13. Stomach

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 466,847 cells
Cluster 164,250 cells
Cluster 2361,362 cells
Cluster 2548,633 cells
Cluster 1744,284 cells
Cluster 2143,847 cells
Cluster 1539,112 cells
Cluster 937,296 cells
Cluster 4832,943 cells
Cluster 3932,700 cells
Cluster 3724,976 cells
Cluster 1022,570 cells
Cluster 5620,674 cells
Cluster 4519,832 cells
Cluster 1119,288 cells
Cluster 1217,258 cells
Cluster 3217,233 cells
Cluster 6015,097 cells
Cluster 4614,773 cells
Cluster 5114,494 cells
Cluster 4414,400 cells
Cluster 1412,706 cells
Cluster 1312,152 cells
Cluster 3011,929 cells
Cluster 6311,927 cells
Cluster 2911,376 cells
Cluster 6111,168 cells
Cluster 2411,012 cells
Cluster 2210,983 cells
Cluster 4910,811 cells
Cluster 2610,763 cells
Cluster 1810,640 cells
Cluster 3310,257 cells
Cluster 5710,183 cells
Cluster 69,852 cells
Cluster 209,775 cells
Cluster 279,755 cells
Cluster 429,543 cells
Cluster 359,502 cells
Cluster 289,287 cells
Cluster 419,083 cells
Cluster 78,764 cells
Cluster 317,870 cells
Cluster 647,577 cells
Cluster 87,540 cells
Cluster 57,270 cells
Cluster 556,992 cells
Cluster 656,841 cells
Cluster 536,490 cells
Cluster 476,195 cells
Cluster 26,191 cells
Cluster 366,026 cells
Cluster 625,796 cells
Cluster 545,590 cells
Cluster 584,869 cells
Cluster 384,792 cells
Cluster 164,597 cells
Cluster 194,566 cells
Cluster 34,418 cells
Cluster 433,945 cells
Cluster 663,722 cells
Cluster 593,593 cells
Cluster 523,590 cells
Cluster 673,323 cells
Cluster 503,009 cells
Cluster 401,999 cells
Cluster 681,559 cells
Cluster 341,298 cells
A panoramic view of cell population dynamics in mammalian aging

14. Brain

Explore
Leiden clustering
Genotype
Sex
Age
Tissue
Cell type
Cell subtype
Cell lineage
Louvain clustering (All cells)
Assay
Sample preservation method
Sample ID
Disease
Mouse strand
Cluster 1381,375 cells
Cluster 2172,295 cells
Cluster 6146,025 cells
Cluster 4105,743 cells
Cluster 15104,121 cells
Cluster 565,902 cells
Cluster 1964,444 cells
Cluster 761,249 cells
Cluster 1152,030 cells
Cluster 1037,052 cells
Cluster 2332,050 cells
Cluster 830,406 cells
Cluster 1427,669 cells
Cluster 1322,019 cells
Cluster 2020,505 cells
Cluster 2520,197 cells
Cluster 914,771 cells
Cluster 1714,356 cells
Cluster 313,978 cells
Cluster 2210,276 cells
Cluster 289,089 cells
Cluster 128,388 cells
Cluster 297,519 cells
Cluster 307,124 cells
Cluster 216,580 cells
Cluster 326,235 cells
Cluster 264,399 cells
Cluster 344,168 cells
Cluster 333,468 cells
Cluster 242,840 cells
Cluster 182,699 cells
Cluster 372,065 cells
Cluster 271,960 cells
Cluster 381,790 cells
Cluster 311,734 cells
Cluster 36816 cells
Cluster 35784 cells
Cluster 16712 cells
Cluster 39278 cells
A panoramic view of cell population dynamics in mammalian aging

Alias names

PanSci, GSE247719