The Immunoregulatory Architecture of the Adult Oral Cavity
Cite
Matuck, B.F., Huynh, K., Pereira, D., Zhang, X., Kunz, M., Kumar, N., Easter, Q.T., Fernandes, A., Ghodke, A., Predeus, A. and Szabo, L., 2024. The Immunoregulatory Architecture of the Adult Oral Cavity. bioRxiv. https://doi.org/10.1101/2024.12.01.626279
Abstract
The oral cavity is a critical barrier with immunosurveillance capabilities. A detailed understanding of its cellular, molecular, and spatial architecture is essential for advancing precision medicine across aerodigestive tissues. Here, we present the first integrated atlas of human adult oral and craniofacial tissues, derived from single-cell RNA sequencing of ∼250,000 cells from 70 samples across 13 niches, including salivary glands and oral mucosae. Complementary spatial atlases using a 40-plex protein and 300-plex transcriptomics panels were developed, covering >2 million cells. Using our new AstroSuite package, we identified 8 tissue cellular neighborhoods (TCNs) and 17 multicellular interaction modules (MCIMs) across gland and mucosae in health. Diverse fibrovascular TCNs emerged as centralized hubs, coordinating immune cell migration and activation. Mucosal hubs within stroma displayed higher immune cell density, diversity, and activation than glands, underscoring differences in functional architecture. In keratinized and nonkeratinized mucosae, common fibrovascular hubs, and MCIMs revealed a specialized biogeography of immunoregulation. Under chronic inflammation, mucosal TCNs were fragmented, and MCIMs involving fibroblasts and immune cells were reorganized and expanded. Focused analysis of tertiary lymphoid structures (TLS) and fibroblasts identified TLS-associated MCIMs and drug candidates targeting these spatial interactions, offering a foundational framework for broadly dissecting mucosal immunity to guide precision medicine approaches.
Datasets
1. Oral and Craniofacial Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
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Collection relative time point
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Sample collection year
Library preparation batch
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Epithelial cells62303 cells
Vasculature58065 cells
Lymphoid cells49863 cells
Fibroblasts46247 cells
Myeloid cells19492 cells
Neural Crest-derived9664 cells
Mineralized443 cells
Muscle cells26 cells
P513265 cells
DP1010895 cells
MSG710842 cells
P29837 cells
SMG18952 cells
B78738 cells
B48734 cells
HP28233 cells
DP17725 cells
G97436 cells
DP26639 cells
G56461 cells
MSG66023 cells
G125974 cells
Tong25679 cells
G115487 cells
SMG25191 cells
SLG15180 cells
DP35098 cells
DP65005 cells
G74564 cells
MSG94345 cells
Tong44221 cells
Tong33933 cells
G103796 cells
DP53720 cells
B83512 cells
DP73434 cells
P13385 cells
DP43229 cells
G153059 cells
B53032 cells
Tong12999 cells
G132916 cells
DP82803 cells
MSG82800 cells
G22559 cells
P32526 cells
G182221 cells
MSG52198 cells
G172002 cells
G12002 cells
G81991 cells
P41970 cells
B31904 cells
MSG31855 cells
G31626 cells
B61475 cells
MSG21473 cells
G161455 cells
DP121445 cells
Pd41074 cells
MSG41033 cells
MSG1904 cells
SP1835 cells
L5748 cells
L4738 cells
DP11579 cells
HP1574 cells
G19498 cells
B2480 cells
Pd3472 cells
Pd2467 cells
L3393 cells
DP9393 cells
G14389 cells
Pd5322 cells
L1175 cells
L2156 cells
Pd129 cells
Williams et al.72687 cells
Tabula Sapiens35234 cells
Pagella et al.28775 cells
Costa-da-Silva et al.24010 cells
Krivanek et al.22530 cells
Horeth et al.14143 cells
Huang et al.13639 cells
Chen et al.13265 cells
Ko et al.8807 cells
Pringle et al.4496 cells
Caetano et al.3448 cells
Warner et al.2210 cells
Opasawatchai et al.2024 cells
Kretzschmar et al.835 cells
Gingival Mucosa54436 cells
Dental Pulp50965 cells
Minor Salivary Gland31473 cells
Parotid Salivary Gland30983 cells
Buccal Mucosa27875 cells
Dorsal Tongue16832 cells
Submandibular Gland14143 cells
Hard Palate8807 cells
Sublingual Gland5180 cells
Periodontium2364 cells
Labial Mucosa2210 cells
Soft Palate835 cells
Tabula Sapiens_TSP1423171 cells
Chen_parotid gland 113265 cells
Tabula Sapiens_TSP712063 cells
Krivanek_510895 cells
Costa-da-Silva_HV210842 cells
Horeth_Submandibular Gland 128952 cells
Williams_BM1688738 cells
Williams_BM1578734 cells
Ko_replicate 28233 cells
Pagella_Pulp17725 cells
Williams_GM2387436 cells
Pagella_Pulp26639 cells
Williams_GM1486461 cells
Costa-da-Silva_HV16023 cells
Williams_GM2835974 cells
Williams_GM2425487 cells
Horeth_Submandibular Gland 155191 cells
Pagella_Pulp35098 cells
Krivanek_15005 cells
Williams_GM1834564 cells
Costa-da-Silva_HV44345 cells
Williams_GM2413796 cells
Pagella_Pulp53720 cells
Williams_BM1693512 cells
Krivanek_23434 cells
Pagella_Pulp43229 cells
Caetano_Healthy23059 cells
Williams_BM1583032 cells
Williams_GM2892916 cells
Krivanek_32803 cells
Costa-da-Silva_HV32800 cells
Williams_GM1432559 cells
Pringle_12526 cells
Huang_ATL0032221 cells
Huang_MSG132198 cells
Williams_GM1362002 cells
Huang_ATL0022002 cells
Williams_GM1841991 cells
Pringle_21970 cells
Williams_BM1561904 cells
Huang_MSG91855 cells
Williams_GM1441626 cells
Williams_BM1651475 cells
Huang_MSG81473 cells
Huang_ATL0011455 cells
Opasawatchai_Donor C1445 cells
Pagella_Perio41074 cells
Huang_MSG111033 cells
Huang_MSG7904 cells
Kretzschmar_1835 cells
Warner_3633748 cells
Warner_3632738 cells
Opasawatchai_Donor A579 cells
Ko_replicate 1574 cells
Huang_ATL005498 cells
Williams_BM152480 cells
Pagella_Perio3472 cells
Pagella_Perio2467 cells
Krivanek_4393 cells
Warner_3631393 cells
Caetano_Healthy1389 cells
Pagella_Perio5322 cells
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Warner_3630156 cells
Pagella_Perio129 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359928/72687 cells
https://www.science.org/stoken/author-tokens/ST-495/full35234 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099559/28775 cells
https://www.sciencedirect.com/science/article/pii/S2589004221015625?via%3Dihub24010 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511944/22530 cells
https://journals.sagepub.com/doi/10.1177/00220345221147908?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed14143 cells
https://www.nature.com/articles/s41591-021-01296-813639 cells
https://journals.sagepub.com/doi/full/10.1177/0022034522107606913265 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827523/8807 cells
Unassigned7541 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781605/3448 cells
https://www.frontiersin.org/articles/10.3389/fdmed.2021.806294/full2024 cells
National Institute of Dental and Craniofacial Research (NIDCR)112546 cells
Chan-Zuckerberg BioHub35234 cells
University of Zurich26411 cells
Medical University of Vienna22530 cells
University at Buffalo14143 cells
Sichuan University13265 cells
University of Pennsylvania8807 cells
University Medical Center Groningen4496 cells
King's College London3448 cells
University of Zurich (UZH)2364 cells
Mahidol University2024 cells
MSNZ University of Würzburg835 cells
site_1_USA110336 cells
site_2_USA35234 cells
site_1_Switzerland28775 cells
site_1_Austria22530 cells
site_3_USA14143 cells
site_1_China13265 cells
site_4_USA8807 cells
site_1_Netherlands4496 cells
site_1_UK3448 cells
Unassigned2210 cells
site_1_Thailand2024 cells
site_1_Germany835 cells
Unassigned210869 cells
day135234 cells
TSP1423171 cells
parotid gland 113265 cells
TSP712063 cells
Donor510895 cells
HV210842 cells
Submandibular Gland 12 scRNA8952 cells
BM1688738 cells
BM1578734 cells
replicate 28233 cells
Pulp17725 cells
GM2387436 cells
Pulp26639 cells
GM1486461 cells
HV16023 cells
GM2835974 cells
GM2425487 cells
N/A5331 cells
Submandibular Gland 15 scRNA5191 cells
Pulp35098 cells
Donor15005 cells
GM1834564 cells
HV44345 cells
GM2413796 cells
Pulp53720 cells
BM1693512 cells
Donor23434 cells
Pulp43229 cells
Healthy23059 cells
BM1583032 cells
GM2892916 cells
Donor32803 cells
HV32800 cells
GM1432559 cells
ATL0032221 cells
MSG132198 cells
GM1362002 cells
ATL0022002 cells
GM1841991 cells
BM1561904 cells
MSG91855 cells
GM1441626 cells
BM1651475 cells
MSG81473 cells
ATL0011455 cells
DTP_041445 cells
Perio41074 cells
MSG111033 cells
MSG7904 cells
Muc26748 cells
Muc25738 cells
DTP_01579 cells
replicate 1574 cells
ATL005498 cells
BM152480 cells
Perio3472 cells
Perio2467 cells
Donor4393 cells
Muc24393 cells
Healthy1389 cells
Perio5322 cells
Muc22175 cells
Muc23156 cells
Perio129 cells
Unassigned56414 cells
GSM5683602 13265 cells
GSM4365610 10895 cells
GSM5464616 10842 cells
GSM5965738 8952 cells
GSM51770378738 cells
GSM50050468734 cells
GSM67254568233 cells
GSM49984577725 cells
GSM50050557436 cells
GSM49984586639 cells
GSM50050526461 cells
GSM54646156023 cells
GSM51770405974 cells
GSM50050575487 cells
GSM5965739 5191 cells
GSM49984595098 cells
GSM4365608 5005 cells
GSM50050534564 cells
GSM54646184345 cells
GSM50050563796 cells
GSM49984613720 cells
GSM51770383512 cells
GSM43656073434 cells
GSM49984603229 cells
GSM46008973059 cells
GSM50050473032 cells
GSM51770412916 cells
GSM43656022803 cells
GSM54646172800 cells
GSM50050492559 cells
GSM50050482002 cells
GSM50050541991 cells
GSM50050451904 cells
GSM50050501626 cells
GSM51770361475 cells
GSM56084291445 cells
GSM4904137 1074 cells
GSM5608427579 cells
GSM6725455574 cells
GSM5005044480 cells
GSM4904136 472 cells
GSM4904135 467 cells
GSM4365603 393 cells
GSM4600896389 cells
GSM4904138 322 cells
GSM4904134 29 cells
not applicable210869 cells
235234 cells
surgical donor210869 cells
postmortem donor35234 cells
biopsy175226 cells
surgical resection42102 cells
scraping28775 cells
healthy228342 cells
adjacent17761 cells
Unassigned89009 cells
Labial minor salivary gland24010 cells
Third molar22530 cells
Parotid salivary gland17718 cells
Submandibular gland14143 cells
Lower pole of the parotid salivary gland 13265 cells
Posterior tongue: circumvallate papilla anterior to sulcus terminalis9900 cells
Rugous Area anterior Hard palate8807 cells
Mandibular labial minor salivary glands7463 cells
Anterior tongue: tongue dorsum 6932 cells
13-146461 cells
Palatal side, interdental papilla #14 distal/15 mesial 6176 cells
Sublingual gland5180 cells
Buccal gingival margin UR3/UL33059 cells
Mandibular labial mucosa3045 cells
Apical two-thirds of the roots of extracted third molars2364 cells
Tooh number 18 (upper maxillary right third molar)2024 cells
14-162002 cells
16-171626 cells
Buccal gingival margin UR6
389 cells
fresh238562 cells
frozen at -80C6706 cells
frozen at -150C835 cells
Unassigned239927 cells
20196176 cells
Unassigned177783 cells
batch0145138 cells
batch0223182 cells
Unassigned137005 cells
run180237 cells
run220707 cells
run44221 cells
run33933 cells
3 prime tag246103 cells
GRCh38246103 cells
v98246103 cells
STAR v2.7.10a_alpha_220818 / STARsolo246103 cells
no246103 cells
N/A121017 cells
White84843 cells
Asian29785 cells
Black6465 cells
Latino2002 cells
American Indian1991 cells
18-39157412 cells
50-5941064 cells
60-6934622 cells
40-4913005 cells
epithelial cell62303 cells
lymphocyte49863 cells
fibroblast46247 cells
endothelial cell of vascular tree43549 cells
myeloid cell19492 cells
mural cell14516 cells
Schwann cell9366 cells
odontoblast443 cells
melanocyte298 cells
muscle cell26 cells
10x 3' v3183135 cells
10x 3' v262968 cells
normal246103 cells
male102224 cells
female92574 cells
Unassigned51305 cells
gingiva54436 cells
dental pulp50965 cells
minor salivary gland31473 cells
parotid gland30983 cells
buccal mucosa27875 cells
mucosa of dorsum of tongue16832 cells
submandibular gland14143 cells
hard palate8807 cells
sublingual gland5180 cells
periodontium2364 cells
mucosa of lip2210 cells
soft palate835 cells
Unassigned121017 cells
European84843 cells
Asian29785 cells
African6465 cells
Hispanic or Latin American2002 cells
Native American1991 cells
Cluster 1147060 cells
Cluster 336771 cells
Cluster 832567 cells
Cluster 431273 cells
Cluster 122836 cells
Cluster 716806 cells
Cluster 515303 cells
Cluster 210982 cells
Cluster 96695 cells
Cluster 66099 cells
Cluster 105176 cells
Cluster 123074 cells
Cluster 142797 cells
Cluster 132342 cells
Cluster 191506 cells
Cluster 161107 cells
Cluster 18568 cells
Cluster 25497 cells
Cluster 15491 cells
Cluster 22459 cells
Cluster 23434 cells
Cluster 21388 cells
Cluster 24327 cells
Cluster 17245 cells
Cluster 20210 cells
Cluster 2690 cells
2. Mucosal Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Vascular endothelial cells23920 cells
Fibroblasts19235 cells
CD4 T cells7644 cells
Mural cells7375 cells
Keratinocytes6802 cells
CD8 T cells5367 cells
Plasma cells2768 cells
Lymphatic endothelial cells2278 cells
Mast cells1960 cells
Monocytes/Macrophages1925 cells
Natural Killer cells1604 cells
B cells1544 cells
Dendritic cells1497 cells
Neutrophils814 cells
Langerhans cells618 cells
Acinar cells558 cells
Melanocytes374 cells
Schwann cells323 cells
Ductal epithelial cells265 cells
Merkel cells52 cells
Muscle cells51 cells
Myoepithelial cells26 cells
B48611 cells
B78456 cells
HP27863 cells
G97435 cells
G56461 cells
G125974 cells
G115487 cells
G74564 cells
G103796 cells
B83425 cells
G153059 cells
B53012 cells
G132916 cells
G22559 cells
G12002 cells
G81991 cells
B31870 cells
G31626 cells
B61455 cells
SP1831 cells
L5745 cells
L4732 cells
HP1569 cells
B2460 cells
G14389 cells
L3388 cells
L1174 cells
L2150 cells
Williams et al.72100 cells
Ko et al.8432 cells
Caetano et al.3448 cells
Warner, et al.2189 cells
Kretzschmar et al.831 cells
Gingival Mucosa48259 cells
Buccal Mucosa27289 cells
Hard Palate8432 cells
Labial Mucosa2189 cells
Soft Palate831 cells
Williams_BM1578611 cells
Williams_BM1688456 cells
Ko_replicate 27863 cells
Williams_GM2387435 cells
Williams_GM1486461 cells
Williams_GM2835974 cells
Williams_GM2425487 cells
Williams_GM1834564 cells
Williams_GM2413796 cells
Williams_BM1693425 cells
Caetano_Healthy23059 cells
Williams_BM1583012 cells
Williams_GM2892916 cells
Williams_GM1432559 cells
Williams_GM1362002 cells
Williams_GM1841991 cells
Williams_BM1561870 cells
Williams_GM1441626 cells
Williams_BM1651455 cells
Kretzschmar_1831 cells
Warner_3633745 cells
Warner_3632732 cells
Ko_replicate 1569 cells
Williams_BM152460 cells
Caetano_Healthy1389 cells
Warner_3631388 cells
Warner_3629174 cells
Warner_3630150 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359928/72100 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827523/8432 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781605/3448 cells
Unassigned3020 cells
National Institute of Dental and Craniofacial Research (NIDCR)74289 cells
University of Pennsylvania8432 cells
King's College London3448 cells
MSNZ University of Würzburg831 cells
site_1_USA72100 cells
site_4_USA8432 cells
site_1_UK3448 cells
Unassigned2189 cells
site_1_Germany831 cells
BM1578611 cells
BM1688456 cells
replicate 27863 cells
GM2387435 cells
GM1486461 cells
GM2835974 cells
GM2425487 cells
GM1834564 cells
GM2413796 cells
BM1693425 cells
Healthy23059 cells
BM1583012 cells
GM2892916 cells
GM1432559 cells
GM1362002 cells
GM1841991 cells
BM1561870 cells
GM1441626 cells
BM1651455 cells
N/A831 cells
Muc26745 cells
Muc25732 cells
replicate 1569 cells
BM152460 cells
Healthy1389 cells
Muc24388 cells
Muc22174 cells
Muc23150 cells
GSM50050468611 cells
GSM51770378456 cells
GSM67254567863 cells
GSM50050557435 cells
GSM50050526461 cells
GSM51770405974 cells
GSM50050575487 cells
GSM50050534564 cells
GSM50050563796 cells
GSM51770383425 cells
GSM46008973059 cells
Unassigned3020 cells
GSM50050473012 cells
GSM51770412916 cells
GSM50050492559 cells
GSM50050482002 cells
GSM50050541991 cells
GSM50050451870 cells
GSM50050501626 cells
GSM51770361455 cells
GSM6725455569 cells
GSM5005044460 cells
GSM4600896389 cells
not applicable87000 cells
surgical donor87000 cells
biopsy82721 cells
surgical resection4279 cells
healthy87000 cells
Unassigned62011 cells
Rugous Area anterior Hard palate8432 cells
13-146461 cells
Buccal gingival margin UR3/UL33059 cells
Mandibular labial mucosa3020 cells
14-162002 cells
16-171626 cells
Buccal gingival margin UR6
389 cells
fresh83980 cells
frozen at -80C2189 cells
frozen at -150C831 cells
Unassigned78568 cells
run18432 cells
3 prime tag87000 cells
GRCh3887000 cells
v9887000 cells
STAR v2.7.10a_alpha_220818 / STARsolo87000 cells
no87000 cells
White40663 cells
Asian29483 cells
Unassigned8432 cells
Black4429 cells
Latino2002 cells
American Indian1991 cells
18-3970060 cells
50-5912856 cells
60-694084 cells
blood vessel endothelial cell23920 cells
fibroblast19235 cells
CD4-positive helper T cell7644 cells
mural cell7375 cells
keratinocyte6802 cells
CD8-positive, alpha-beta T cell5367 cells
plasma cell2768 cells
endothelial cell of lymphatic vessel2278 cells
mast cell1960 cells
macrophage1925 cells
natural killer cell1604 cells
B cell1544 cells
dendritic cell1497 cells
neutrophil814 cells
Langerhans cell618 cells
acinar cell of salivary gland558 cells
melanocyte374 cells
Schwann cell323 cells
salivary gland glandular cell265 cells
Merkel cell52 cells
adult skeletal muscle myoblast51 cells
myoepithelial cell26 cells
10x 3' v351079 cells
10x 3' v235921 cells
normal87000 cells
female59388 cells
male27612 cells
gingiva48259 cells
buccal mucosa27289 cells
hard palate8432 cells
mucosa of lip2189 cells
soft palate831 cells
European40663 cells
Asian29483 cells
Unassigned8432 cells
African4429 cells
Hispanic or Latin American2002 cells
Native American1991 cells
Cluster 519901 cells
Cluster 319271 cells
Cluster 414697 cells
Cluster 77314 cells
Cluster 16761 cells
Cluster 106648 cells
Cluster 24683 cells
Cluster 63599 cells
Cluster 82203 cells
Cluster 91923 cells
3. Pulp Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection ite
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Age
Cell type
Assay
Disease
Sex
Tissue
Leiden clustering
Fibroblasts23077 cells
Vascular endothelial cells10658 cells
Mural cells6281 cells
Schwann cells6166 cells
Monocytes/Macrophages1555 cells
CD4 T cells1060 cells
CD8 T cells1053 cells
Odontoblasts620 cells
Natural Killer cells217 cells
Neutrophils89 cells
Dendritic cells81 cells
Peripherial neurons51 cells
B cells19 cells
DP1010895 cells
DP17725 cells
DP26619 cells
DP35077 cells
DP65005 cells
DP53722 cells
DP73434 cells
DP43230 cells
DP82803 cells
DP121445 cells
DP11579 cells
DP9393 cells
Pagella et al.26373 cells
Krivanek et al.22530 cells
Opasawatchai et al.2024 cells
Dental Pulp50927 cells
Krivanek_510895 cells
Pagella_Pulp17725 cells
Pagella_Pulp26619 cells
Pagella_Pulp35077 cells
Krivanek_15005 cells
Pagella_Pulp53722 cells
Krivanek_23434 cells
Pagella_Pulp43230 cells
Krivanek_32803 cells
Opasawatchai_Donor C1445 cells
Opasawatchai_Donor A579 cells
Krivanek_4393 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099559/26373 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511944/22530 cells
https://www.frontiersin.org/articles/10.3389/fdmed.2021.806294/full2024 cells
University of Zurich26373 cells
Medical University of Vienna22530 cells
Mahidol University2024 cells
site_1_Switzerland26373 cells
site_1_Austria22530 cells
site_1_Thailand2024 cells
Donor510895 cells
Pulp17725 cells
Pulp26619 cells
Pulp35077 cells
Donor15005 cells
Pulp53722 cells
Donor23434 cells
Pulp43230 cells
Donor32803 cells
DTP_041445 cells
DTP_01579 cells
Donor4393 cells
GSM4365610 10895 cells
GSM49984577725 cells
GSM49984586619 cells
GSM49984595077 cells
GSM4365608 5005 cells
GSM49984613722 cells
GSM43656073434 cells
GSM49984603230 cells
GSM43656022803 cells
GSM56084291445 cells
GSM5608427579 cells
GSM4365603 393 cells
not applicable50927 cells
surgical donor50927 cells
scraping26373 cells
surgical resection24554 cells
healthy50927 cells
Unassigned26373 cells
Third molar22530 cells
Tooh number 18 (upper maxillary right third molar)2024 cells
fresh50927 cells
3 prime tag50927 cells
GRCh3850927 cells
v9850927 cells
STAR v2.7.10a_alpha_220818 / STARsolo50927 cells
no50927 cells
18-3950927 cells
fibroblast23077 cells
blood vessel endothelial cell10658 cells
mural cell6281 cells
Schwann cell6166 cells
macrophage1555 cells
CD4-positive helper T cell1060 cells
CD8-positive, alpha-beta T cell1053 cells
odontoblast620 cells
natural killer cell217 cells
neutrophil89 cells
dendritic cell81 cells
peripheral nervous system neuron51 cells
B cell19 cells
10x 3' v326286 cells
10x 3' v224641 cells
normal50927 cells
Unassigned48903 cells
female2024 cells
dental pulp50927 cells
Cluster 112408 cells
Cluster 610323 cells
Cluster 29783 cells
Cluster 76349 cells
Cluster 53761 cells
Cluster 82320 cells
Cluster 42226 cells
Cluster 91704 cells
Cluster 31648 cells
Cluster 10356 cells
Cluster 1149 cells
4. Gland Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Sample collection relative time point
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sample site condition
Tooth region
Sample preservation method
Library preparation batch
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Acinar cells29997 cells
Ductal epithelial cells3846 cells
Fibroblasts3630 cells
Plasma cells2979 cells
Vascular endothelial cells2205 cells
CD8 T cells2063 cells
Monocytes/Macrophages1092 cells
Mural cells778 cells
Neutrophils665 cells
CD4 T cells657 cells
Keratinocytes586 cells
Schwann cells529 cells
Dendritic cells331 cells
Ionocytes315 cells
Myoepithelial cells220 cells
Natural Killer cells155 cells
Lymphatic endothelial cells81 cells
Muscle cells56 cells
B cells55 cells
MSG710842 cells
SMG18952 cells
MSG66023 cells
SMG25190 cells
MSG94345 cells
MSG82798 cells
P32526 cells
MSG52198 cells
P41958 cells
MSG31853 cells
MSG21472 cells
MSG41033 cells
MSG1904 cells
P2104 cells
P142 cells
Costa-da-Silva et al.24008 cells
Horeth et al.14142 cells
Huang et al.7460 cells
Pringle et al.4484 cells
Tabula Sapiens146 cells
Minor Salivary Gland31468 cells
Submandibular Gland14142 cells
Parotid Salivary Gland4630 cells
Costa-da-Silva_HV210842 cells
Horeth_Submandibular Gland 128952 cells
Costa-da-Silva_HV16023 cells
Horeth_Submandibular Gland 155190 cells
Costa-da-Silva_HV44345 cells
Costa-da-Silva_HV32798 cells
Pringle_12526 cells
Huang_MSG132198 cells
Pringle_21958 cells
Huang_MSG91853 cells
Huang_MSG81472 cells
Huang_MSG111033 cells
Huang_MSG7904 cells
Tabula Sapiens_TSP14104 cells
Tabula Sapiens_TSP742 cells
https://www.sciencedirect.com/science/article/pii/S2589004221015625?via%3Dihub24008 cells
https://journals.sagepub.com/doi/10.1177/00220345221147908?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed14142 cells
https://www.nature.com/articles/s41591-021-01296-87460 cells
Unassigned4484 cells
https://www.science.org/stoken/author-tokens/ST-495/full146 cells
National Institute of Dental and Craniofacial Research (NIDCR)31468 cells
University at Buffalo14142 cells
University Medical Center Groningen4484 cells
Chan-Zuckerberg BioHub146 cells
site_1_USA31468 cells
site_3_USA14142 cells
site_1_Netherlands4484 cells
site_2_USA146 cells
Unassigned50094 cells
day1146 cells
HV210842 cells
Submandibular Gland 12 scRNA8952 cells
HV16023 cells
Submandibular Gland 15 scRNA5190 cells
N/A4484 cells
HV44345 cells
HV32798 cells
MSG132198 cells
MSG91853 cells
MSG81472 cells
MSG111033 cells
MSG7904 cells
TSP14104 cells
TSP742 cells
Unassigned12090 cells
GSM5464616 10842 cells
GSM5965738 8952 cells
GSM54646156023 cells
GSM5965739 5190 cells
GSM54646184345 cells
GSM54646172798 cells
not applicable50094 cells
2146 cells
surgical donor50094 cells
postmortem donor146 cells
biopsy50240 cells
healthy45756 cells
adjacent4484 cells
Labial minor salivary gland24008 cells
Submandibular gland14142 cells
Mandibular labial minor salivary glands7460 cells
Parotid salivary gland4630 cells
fresh45756 cells
frozen at -80C4484 cells
Unassigned35952 cells
batch018994 cells
batch025294 cells
run140462 cells
run25294 cells
Unassigned4484 cells
3 prime tag50240 cells
GRCh3850240 cells
v9850240 cells
STAR v2.7.10a_alpha_220818 / STARsolo50240 cells
no50240 cells
Unassigned45610 cells
White4630 cells
18-3926870 cells
40-4913003 cells
60-695232 cells
50-595135 cells
acinar cell of salivary gland29997 cells
salivary gland glandular cell3846 cells
fibroblast3630 cells
plasma cell2979 cells
blood vessel endothelial cell2205 cells
CD8-positive, alpha-beta T cell2063 cells
macrophage1092 cells
mural cell778 cells
neutrophil665 cells
CD4-positive helper T cell657 cells
keratinocyte586 cells
Schwann cell529 cells
dendritic cell331 cells
ionocyte315 cells
myoepithelial cell220 cells
natural killer cell155 cells
endothelial cell of lymphatic vessel81 cells
adult skeletal muscle myoblast56 cells
B cell55 cells
10x 3' v350240 cells
normal50240 cells
male33636 cells
female16604 cells
minor salivary gland31468 cells
submandibular gland14142 cells
parotid gland4630 cells
Unassigned45610 cells
European4630 cells
Cluster 714525 cells
Cluster 17160 cells
Cluster 36387 cells
Cluster 25610 cells
Cluster 103551 cells
Cluster 62734 cells
Cluster 92319 cells
Cluster 112187 cells
Cluster 52064 cells
Cluster 81522 cells
Cluster 12804 cells
Cluster 13779 cells
Cluster 4598 cells
5. Minor Salivary Gland Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protoco url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Age
Cell type
Assay
Disease
Sex
Tissue
Leiden clustering
Acinar cells18786 cells
Fibroblasts2800 cells
Plasma cells2455 cells
Ductal epithelial cells2361 cells
Vascular endothelial cells1513 cells
CD8 T cells1025 cells
Mural cells606 cells
Myoepithelial cells431 cells
Monocytes/Macrophages416 cells
CD4 T cells300 cells
Keratinocytes214 cells
Dendritic cells168 cells
Ionocytes110 cells
Neutrophils92 cells
Lymphatic endothelial cells78 cells
Muscle cells47 cells
B cells35 cells
Natural Killer cells31 cells
MSG710842 cells
MSG66023 cells
MSG94345 cells
MSG82798 cells
MSG52198 cells
MSG31853 cells
MSG21472 cells
MSG41033 cells
MSG1904 cells
Costa-da-Silva et al.24008 cells
Huang et al.7460 cells
Minor Salivary Gland31468 cells
Costa-da-Silva_HV210842 cells
Costa-da-Silva_HV16023 cells
Costa-da-Silva_HV44345 cells
Costa-da-Silva_HV32798 cells
Huang_MSG132198 cells
Huang_MSG91853 cells
Huang_MSG81472 cells
Huang_MSG111033 cells
Huang_MSG7904 cells
https://www.sciencedirect.com/science/article/pii/S2589004221015625?via%3Dihub24008 cells
https://www.nature.com/articles/s41591-021-01296-87460 cells
National Institute of Dental and Craniofacial Research (NIDCR)31468 cells
site_1_USA31468 cells
HV210842 cells
HV16023 cells
HV44345 cells
HV32798 cells
MSG132198 cells
MSG91853 cells
MSG81472 cells
MSG111033 cells
MSG7904 cells
GSM5464616 10842 cells
Unassigned7460 cells
GSM54646156023 cells
GSM54646184345 cells
GSM54646172798 cells
not applicable31468 cells
surgical donor31468 cells
biopsy31468 cells
healthy31468 cells
Labial minor salivary gland24008 cells
Mandibular labial minor salivary glands7460 cells
fresh31468 cells
run131468 cells
3 prime tag31468 cells
GRCh3831468 cells
v9831468 cells
STAR v2.7.10a_alpha_220818 / STARsolo31468 cells
no31468 cells
18-3924912 cells
40-494051 cells
50-592505 cells
acinar cell of salivary gland18786 cells
fibroblast2800 cells
plasma cell2455 cells
salivary gland glandular cell2361 cells
blood vessel endothelial cell1513 cells
CD8-positive, alpha-beta T cell1025 cells
mural cell606 cells
myoepithelial cell431 cells
macrophage416 cells
CD4-positive helper T cell300 cells
keratinocyte214 cells
dendritic cell168 cells
ionocyte110 cells
neutrophil92 cells
endothelial cell of lymphatic vessel78 cells
adult skeletal muscle myoblast47 cells
B cell35 cells
natural killer cell31 cells
10x 3' v331468 cells
normal31468 cells
male20096 cells
female11372 cells
minor salivary gland31468 cells
Cluster 310604 cells
Cluster 15986 cells
Cluster 23721 cells
Cluster 52784 cells
Cluster 111680 cells
Cluster 41597 cells
Cluster 91565 cells
Cluster 61326 cells
Cluster 8686 cells
Cluster 12641 cells
Cluster 10632 cells
Cluster 7246 cells
6. Buccal and Labial Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Vascular endothelial cells9788 cells
Fibroblasts6524 cells
Mural cells2641 cells
CD4 T cells2167 cells
CD8 T cells1932 cells
Keratinocytes1738 cells
Lymphatic endothelial cells877 cells
Dendritic cells744 cells
Monocytes/Macrophages699 cells
Natural Killer cells603 cells
Acinar cells451 cells
Langerhans cells365 cells
Plasma cells203 cells
Melanocytes202 cells
Ductal epithelial cells176 cells
Neutrophils171 cells
Mast cells105 cells
Schwann cells70 cells
Myoepithelial cells22 cells
B48611 cells
B78456 cells
B83425 cells
B53012 cells
B31870 cells
B61455 cells
L5745 cells
L4732 cells
B2460 cells
L3388 cells
L1174 cells
L2150 cells
Williams et al.27289 cells
Warner, et al.2189 cells
Buccal Mucosa27289 cells
Labial Mucosa2189 cells
Williams_BM1578611 cells
Williams_BM1688456 cells
Williams_BM1693425 cells
Williams_BM1583012 cells
Williams_BM1561870 cells
Williams_BM1651455 cells
Warner_3633745 cells
Warner_3632732 cells
Williams_BM152460 cells
Warner_3631388 cells
Warner_3629174 cells
Warner_3630150 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359928/27289 cells
Unassigned2189 cells
National Institute of Dental and Craniofacial Research (NIDCR)29478 cells
site_1_USA27289 cells
Unassigned2189 cells
BM1578611 cells
BM1688456 cells
BM1693425 cells
BM1583012 cells
BM1561870 cells
BM1651455 cells
Muc26745 cells
Muc25732 cells
BM152460 cells
Muc24388 cells
Muc22174 cells
Muc23150 cells
GSM50050468611 cells
GSM51770378456 cells
GSM51770383425 cells
GSM50050473012 cells
Unassigned2189 cells
GSM50050451870 cells
GSM51770361455 cells
GSM5005044460 cells
not applicable29478 cells
surgical donor29478 cells
biopsy29478 cells
healthy29478 cells
Unassigned27289 cells
Mandibular labial mucosa2189 cells
fresh27289 cells
frozen at -80C2189 cells
3 prime tag29478 cells
GRCh3829478 cells
v9829478 cells
STAR v2.7.10a_alpha_220818 / STARsolo29478 cells
no29478 cells
White18692 cells
Asian8916 cells
Black1870 cells
18-3927463 cells
60-691627 cells
50-59388 cells
blood vessel endothelial cell9788 cells
fibroblast6524 cells
mural cell2641 cells
CD4-positive helper T cell2167 cells
CD8-positive, alpha-beta T cell1932 cells
keratinocyte1738 cells
endothelial cell of lymphatic vessel877 cells
dendritic cell744 cells
macrophage699 cells
natural killer cell603 cells
acinar cell of salivary gland451 cells
Langerhans cell365 cells
plasma cell203 cells
melanocyte202 cells
salivary gland glandular cell176 cells
neutrophil171 cells
mast cell105 cells
Schwann cell70 cells
myoepithelial cell22 cells
10x 3' v329478 cells
normal29478 cells
female15604 cells
male13874 cells
buccal mucosa27289 cells
mucosa of lip2189 cells
European18692 cells
Asian8916 cells
African1870 cells
Cluster 68140 cells
Cluster 56579 cells
Cluster 44737 cells
Cluster 72627 cells
Cluster 101918 cells
Cluster 31716 cells
Cluster 11597 cells
Cluster 21061 cells
Cluster 8855 cells
Cluster 9207 cells
Cluster 1141 cells
7. Major Salivary Gland Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Sample collection relative time point
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Library preparation batch
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Acinar cells11211 cells
Ductal epithelial cells1485 cells
CD8 T cells1038 cells
Fibroblasts830 cells
Vascular endothelial cells741 cells
Monocytes/Macrophages676 cells
Neutrophils572 cells
Plasma cells523 cells
Myoepithelial cells381 cells
CD4 T cells357 cells
Keratinocytes274 cells
Ionocytes205 cells
Mural cells172 cells
Dendritic cells163 cells
Natural Killer cells124 cells
B cells20 cells
SMG18952 cells
SMG25190 cells
P32526 cells
P41958 cells
P2104 cells
P142 cells
Horeth et al.14142 cells
Pringle et al.4484 cells
Tabula Sapiens146 cells
Submandibular Gland14142 cells
Parotid Salivary Gland4630 cells
Horeth_Submandibular Gland 128952 cells
Horeth_Submandibular Gland 155190 cells
Pringle_12526 cells
Pringle_21958 cells
Tabula Sapiens_TSP14104 cells
Tabula Sapiens_TSP742 cells
https://journals.sagepub.com/doi/10.1177/00220345221147908?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed14142 cells
Unassigned4484 cells
https://www.science.org/stoken/author-tokens/ST-495/full146 cells
University at Buffalo14142 cells
University Medical Center Groningen4484 cells
Chan-Zuckerberg BioHub146 cells
site_3_USA14142 cells
site_1_Netherlands4484 cells
site_2_USA146 cells
Unassigned18626 cells
day1146 cells
Submandibular Gland 12 scRNA8952 cells
Submandibular Gland 15 scRNA5190 cells
N/A4484 cells
TSP14104 cells
TSP742 cells
GSM5965738 8952 cells
GSM5965739 5190 cells
N/A4630 cells
not applicable18626 cells
2146 cells
surgical donor18626 cells
postmortem donor146 cells
biopsy18772 cells
healthy14288 cells
adjacent4484 cells
Submandibular gland14142 cells
Parotid salivary gland4630 cells
fresh14288 cells
frozen at -80C4484 cells
batch018994 cells
batch025294 cells
Unassigned4484 cells
run18994 cells
run25294 cells
Unassigned4484 cells
3 prime tag18772 cells
GRCh3818772 cells
v9818772 cells
STAR v2.7.10a_alpha_220818 / STARsolo18772 cells
no18772 cells
Unassigned14142 cells
White4630 cells
40-498952 cells
60-695232 cells
50-592630 cells
18-391958 cells
acinar cell of salivary gland11211 cells
salivary gland glandular cell1485 cells
CD8-positive, alpha-beta T cell1038 cells
fibroblast830 cells
blood vessel endothelial cell741 cells
macrophage676 cells
neutrophil572 cells
plasma cell523 cells
myoepithelial cell381 cells
CD4-positive helper T cell357 cells
keratinocyte274 cells
ionocyte205 cells
mural cell172 cells
dendritic cell163 cells
natural killer cell124 cells
B cell20 cells
10x 3' v318772 cells
normal18772 cells
male13540 cells
female5232 cells
submandibular gland14142 cells
parotid gland4630 cells
Unassigned14142 cells
European4630 cells
Cluster 55338 cells
Cluster 113340 cells
Cluster 31858 cells
Cluster 91474 cells
Cluster 41258 cells
Cluster 101177 cells
Cluster 8832 cells
Cluster 6807 cells
Cluster 12657 cells
Cluster 13607 cells
Cluster 1591 cells
Cluster 7347 cells
Cluster 2273 cells
Cluster 14213 cells
8. Palate Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Fibroblasts2814 cells
Mural cells1512 cells
Vascular endothelial cells1057 cells
Keratinocytes889 cells
CD4 T cells858 cells
CD8 T cells412 cells
Dendritic cells284 cells
Plasma cells241 cells
Neutrophils209 cells
Monocytes/Macrophages203 cells
Lymphatic endothelial cells190 cells
Schwann cells175 cells
Natural Killer cells154 cells
B cells75 cells
Merkel cells71 cells
Langerhans cells64 cells
Melanocytes29 cells
Mast cells26 cells
HP27863 cells
SP1831 cells
HP1569 cells
Ko et al.8432 cells
Kretzschmar et al.831 cells
Hard Palate8432 cells
Soft Palate831 cells
Ko_replicate 27863 cells
Kretzschmar_1831 cells
Ko_replicate 1569 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827523/8432 cells
Unassigned831 cells
University of Pennsylvania8432 cells
MSNZ University of Würzburg831 cells
site_4_USA8432 cells
site_1_Germany831 cells
replicate 27863 cells
Unassigned831 cells
replicate 1569 cells
GSM67254567863 cells
Unassigned831 cells
GSM6725455569 cells
not applicable9263 cells
surgical donor9263 cells
biopsy8432 cells
surgical resection831 cells
healthy9263 cells
Rugous Area anterior Hard palate8432 cells
Mandibular labial mucosa831 cells
fresh8432 cells
frozen at -150C831 cells
run18432 cells
Unassigned831 cells
3 prime tag9263 cells
GRCh389263 cells
v989263 cells
STAR v2.7.10a_alpha_220818 / STARsolo9263 cells
no9263 cells
Unassigned8432 cells
White831 cells
18-398432 cells
60-69831 cells
fibroblast2814 cells
mural cell1512 cells
blood vessel endothelial cell1057 cells
keratinocyte889 cells
CD4-positive helper T cell858 cells
CD8-positive, alpha-beta T cell412 cells
dendritic cell284 cells
plasma cell241 cells
neutrophil209 cells
macrophage203 cells
endothelial cell of lymphatic vessel190 cells
Schwann cell175 cells
natural killer cell154 cells
B cell75 cells
Merkel cell71 cells
Langerhans cell64 cells
melanocyte29 cells
mast cell26 cells
10x 3' v39263 cells
normal9263 cells
female7863 cells
male1400 cells
hard palate8432 cells
soft palate831 cells
Unassigned8432 cells
European831 cells
Cluster 41670 cells
Cluster 71421 cells
Cluster 151348 cells
Cluster 11953 cells
Cluster 2707 cells
Cluster 5685 cells
Cluster 1646 cells
Cluster 6456 cells
Cluster 10413 cells
Cluster 3276 cells
Cluster 14153 cells
Cluster 12152 cells
Cluster 9144 cells
Cluster 8120 cells
Cluster 13119 cells
9. Mucosal Immune Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Sample collection year
Library preparation batch
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
CD8 T cells6617 cells
CD4 T cells6151 cells
Innate lymphoid cells2149 cells
Mast cells1982 cells
Dendritic cells1928 cells
Monocytes/Macrophages1878 cells
B cells1516 cells
Neutrophils533 cells
Plasma cells310 cells
GSM50050552905 cells
GSM51770402657 cells
GSM50050462119 cells
GSM67254561763 cells
GSM50050571274 cells
ATL0011218 cells
GSM50050471196 cells
GSM51770371018 cells
GSM50050531012 cells
ATL002882 cells
GSM5005052841 cells
GSM5177041793 cells
ATL003756 cells
GSM5005056610 cells
GSM4600897524 cells
GSM5005048500 cells
GSM5005045481 cells
GSM5005049441 cells
GSM5177036395 cells
GSM5005050389 cells
GSM5005054337 cells
GSM5177038285 cells
GSM4600896228 cells
ATL005123 cells
GSM6725455112 cells
Palate 1104 cells
GSM5005044101 cells
Williams et al.17354 cells
Huang et al.2979 cells
Ko et al.1875 cells
Caetano et al.752 cells
Kretzschmar et al.104 cells
Gingival Mucosa15490 cells
Buccal Mucosa5595 cells
Hard Palate1875 cells
Soft Palate104 cells
Williams_GM2382905 cells
Williams_GM2832657 cells
Williams_BM1572119 cells
Ko_replicate 21763 cells
Williams_GM2421274 cells
Huang_ATL0011218 cells
Williams_BM1581196 cells
Williams_BM1681018 cells
Williams_GM1831012 cells
Huang_ATL002882 cells
Williams_GM148841 cells
Williams_GM289793 cells
Huang_ATL003756 cells
Williams_GM241610 cells
Caetano_Healthy2524 cells
Williams_GM136500 cells
Williams_BM156481 cells
Williams_GM143441 cells
Williams_BM165395 cells
Williams_GM144389 cells
Williams_GM184337 cells
Williams_BM169285 cells
Caetano_Healthy1228 cells
Huang_ATL005123 cells
Ko_replicate 1112 cells
Kretzschmar_1104 cells
Williams_BM152101 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359928/17354 cells
https://www.nature.com/articles/s41591-021-01296-82979 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827523/1875 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781605/752 cells
Unassigned104 cells
National Institute of Dental and Craniofacial Research (NIDCR)20333 cells
University of Pennsylvania1875 cells
King's College London752 cells
MSNZ University of Würzburg104 cells
site_1_USA20333 cells
site_4_USA1875 cells
site_1_UK752 cells
site_1_Germany104 cells
GM2382905 cells
GM2832657 cells
BM1572119 cells
replicate 21763 cells
GM2421274 cells
ATL0011218 cells
BM1581196 cells
BM1681018 cells
GM1831012 cells
ATL002882 cells
GM148841 cells
GM289793 cells
ATL003756 cells
GM241610 cells
Healthy2524 cells
GM136500 cells
BM156481 cells
GM143441 cells
BM165395 cells
GM144389 cells
GM184337 cells
BM169285 cells
Healthy1228 cells
ATL005123 cells
replicate 1112 cells
Unassigned104 cells
BM152101 cells
Unassigned3083 cells
GSM50050552905 cells
GSM51770402657 cells
GSM50050462119 cells
GSM67254561763 cells
GSM50050571274 cells
GSM50050471196 cells
GSM51770371018 cells
GSM50050531012 cells
GSM5005052841 cells
GSM5177041793 cells
GSM5005056610 cells
GSM4600897524 cells
GSM5005048500 cells
GSM5005045481 cells
GSM5005049441 cells
GSM5177036395 cells
GSM5005050389 cells
GSM5005054337 cells
GSM5177038285 cells
GSM4600896228 cells
GSM6725455112 cells
GSM5005044101 cells
not applicable23064 cells
surgical donor23064 cells
biopsy22208 cells
surgical resection856 cells
healthy23064 cells
Unassigned15624 cells
Palatal side, interdental papilla #14 distal/15 mesial 2979 cells
Rugous Area anterior Hard palate1875 cells
13-14841 cells
Buccal gingival margin UR3/UL3524 cells
14-16500 cells
16-17389 cells
Buccal gingival margin UR6
228 cells
Mandibular labial mucosa104 cells
fresh22960 cells
frozen at -150C104 cells
Unassigned20085 cells
20192979 cells
Unassigned20208 cells
batch012856 cells
Unassigned18210 cells
run14854 cells
3 prime tag23064 cells
GRCh3823064 cells
v9823064 cells
STAR v2.7.10a_alpha_220818 / STARsolo23064 cells
no23064 cells
White11304 cells
Asian7244 cells
Unassigned1875 cells
Black1804 cells
Latino500 cells
American Indian337 cells
18-3920537 cells
50-592034 cells
60-69493 cells
CD8-positive, alpha-beta T cell6617 cells
CD4-positive helper T cell6151 cells
innate lymphoid cell2149 cells
mast cell1982 cells
dendritic cell1928 cells
macrophage1878 cells
B cell1516 cells
neutrophil533 cells
plasma cell310 cells
10x 3' v314755 cells
10x 3' v28309 cells
normal23064 cells
female15310 cells
male7754 cells
gingiva15490 cells
buccal mucosa5595 cells
hard palate1875 cells
soft palate104 cells
European11304 cells
Asian7244 cells
Unassigned1875 cells
African1804 cells
Hispanic or Latin American500 cells
Native American337 cells
Cluster 37729 cells
Cluster 44830 cells
Cluster 63865 cells
Cluster 22335 cells
Cluster 11979 cells
Cluster 71589 cells
Cluster 5451 cells
Cluster 8286 cells
10. Gland Immune Atlas
ExploreAuthor cell type
Sample ID
Study
Niche
Subject ID
Protocol url
Institute
Sample collection site
Library ID
GEO accession
Manner of death
Sample source
Sample collection method
Sampled site condition
Tooth region
Sample preservation method
Library preparation batch
Library sequencing run
Sequenced fragment
Reference genome
Gene annotation version
Alignment software
Intron inclusion
Ancestry
Age
Cell type
Assay
Disease
Sex
Tissue
Ethnicity
Leiden clustering
Plasma cells2892 cells
CD8 T cells1325 cells
Monocytes/Macrophages832 cells
CD4 T cells587 cells
Neutrophils370 cells
Innate lymphoid cells146 cells
Dendritic cells120 cells
B cells90 cells
MSG61179 cells
P4959 cells
P3873 cells
MSG9527 cells
MSG5508 cells
SMG1399 cells
MSG3391 cells
MSG7384 cells
SMG2367 cells
MSG8298 cells
MSG2207 cells
MSG1148 cells
MSG4122 cells
Costa-da-Silva et al.2388 cells
Pringle et al.1832 cells
Huang et al.1376 cells
Horeth et al.766 cells
Minor Salivary Gland3764 cells
Parotid Salivary Gland1832 cells
Submandibular Gland766 cells
Costa-da-Silva_HV11179 cells
Pringle_2959 cells
Pringle_1873 cells
Costa-da-Silva_HV4527 cells
Huang_MSG13508 cells
Horeth_Submandibular Gland 12399 cells
Huang_MSG9391 cells
Costa-da-Silva_HV2384 cells
Horeth_Submandibular Gland 15367 cells
Costa-da-Silva_HV3298 cells
Huang_MSG8207 cells
Huang_MSG7148 cells
Huang_MSG11122 cells
https://www.sciencedirect.com/science/article/pii/S2589004221015625?via%3Dihub2388 cells
Unassigned1832 cells
https://www.nature.com/articles/s41591-021-01296-81376 cells
https://journals.sagepub.com/doi/10.1177/00220345221147908?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed766 cells
National Institute of Dental and Craniofacial Research (NIDCR)3764 cells
University Medical Center Groningen1832 cells
University at Buffalo766 cells
site_1_USA3764 cells
site_1_Netherlands1832 cells
site_3_USA766 cells
Unassigned1832 cells
HV11179 cells
HV4527 cells
MSG13508 cells
Submandibular Gland 12 scRNA399 cells
MSG9391 cells
HV2384 cells
Submandibular Gland 15 scRNA367 cells
HV3298 cells
MSG8207 cells
MSG7148 cells
MSG11122 cells
Unassigned3208 cells
GSM54646151179 cells
GSM5464618527 cells
GSM5965738 399 cells
GSM5464616 384 cells
GSM5965739 367 cells
GSM5464617298 cells
not applicable6362 cells
surgical donor6362 cells
biopsy6362 cells
healthy4530 cells
adjacent1832 cells
Labial minor salivary gland2388 cells
Parotid salivary gland1832 cells
Mandibular labial minor salivary glands1376 cells
Submandibular gland766 cells
fresh4530 cells
frozen at -80C1832 cells
Unassigned5596 cells
batch01399 cells
batch02367 cells
run14163 cells
Unassigned1832 cells
run2367 cells
3 prime tag6362 cells
GRCh386362 cells
v986362 cells
STAR v2.7.10a_alpha_220818 / STARsolo6362 cells
no6362 cells
Unassigned4530 cells
White1832 cells
18-393495 cells
40-491298 cells
50-591202 cells
60-69367 cells
plasma cell2892 cells
CD8-positive, alpha-beta T cell1325 cells
macrophage832 cells
CD4-positive helper T cell587 cells
neutrophil370 cells
innate lymphoid cell146 cells
dendritic cell120 cells
B cell90 cells
10x 3' v36362 cells
normal6362 cells
male4424 cells
female1938 cells
minor salivary gland3764 cells
parotid gland1832 cells
submandibular gland766 cells
Unassigned4530 cells
European1832 cells
Cluster 11212 cells
Cluster 51171 cells
Cluster 41021 cells
Cluster 7870 cells
Cluster 9728 cells
Cluster 3575 cells
Cluster 11273 cells
Cluster 10177 cells
Cluster 8135 cells
Cluster 6110 cells
Cluster 290 cells
Alias names
Human Oral and Craniofacial Cell Atlas