An atlas of healthy and injured cell states and niches in the human kidney
Cite
Lake, B.B., Menon, R., Winfree, S., Hu, Q., Melo Ferreira, R., Kalhor, K., Barwinska, D., Otto, E.A., Ferkowicz, M., Diep, D. and Plongthongkum, N., 2023. An atlas of healthy and injured cell states and niches in the human kidney. Nature, 619(7970), pp.585-594.
https://doi.org/10.1038/s41586-023-05769-3
Abstract
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods1. Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main cell types, which include rare and previously undescribed cell populations. The multi-omic approach provides detailed transcriptomic profiles, regulatory factors and spatial localizations spanning the entire kidney. We also define 28 cellular states across nephron segments and interstitium that were altered in kidney injury, encompassing cycling, adaptive (successful or maladaptive repair), transitioning and degenerative states. Molecular signatures permitted the localization of these states within injury neighbourhoods using spatial transcriptomics, while large-scale 3D imaging analysis (around 1.2 million neighbourhoods) provided corresponding linkages to active immune responses. These analyses defined biological pathways that are relevant to injury time-course and niches, including signatures underlying epithelial repair that predicted maladaptive states associated with a decline in kidney function. This integrated multimodal spatial cell atlas of healthy and diseased human kidneys represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.
Datasets
1. Integrated Single-nucleus and Single-cell RNA-seq of the Adult Human Kidney
ExploreSample ID
Experiment
Specimen ID
Disease
Disease (level 1)
Disease (level 2)
Subject ID
Tissue region (level 1)
Tissue region (level 2)
Percent of cortex
Percent of medulla
Sample tissue type
Sample source
Cell type
Cell type (subclass l3)
Cell type (subclass l2)
Cell type (subclass l1)
State l2
State
Cell type (class)
Structure
eGFR
BMI
Diabetes history
Hypertension
Assay
Sex
Tissue
Ethnicity
Age
Age group
Leiden clustering
KPMP_20200115B_10X-R13,763 cells KPMP_20191219C_10X-R8,667 cells KPMP_20200702A_10X-R8,609 cells KPMP_20191219B_10X-R8,216 cells KPMP_20190607K-10X-R7,775 cells KPMP_20190607J-10X-R7,481 cells KPMP_20200115A_10X-R7,019 cells KPMP_20200212H_10X-R6,917 cells BUKMAP_20200304F_10X-R6,488 cells KPMP_20200212E_10X-R6,099 cells BUKMAP_20200702D_10X-R6,089 cells KPMP_20191204A_10X-R6,039 cells BUKMAP_20200304B_10X-R5,815 cells BUKMAP_20190529L_10X-R5,744 cells BUKMAP_20200304A_10X-R5,652 cells BUKMAP_20190607L_10X-R5,520 cells KPMP_20191219A_10X-R5,380 cells KPMP_20200212B_10X-R5,113 cells KPMP_20200513A_10X-R4,885 cells BUKMAP_20191010-10X-R4,837 cells KPMP_20200212C_10X-R4,799 cells KPMP_20190607I-10X-R4,765 cells BUKMAP_20200702C_10X-R4,718 cells KPMP_20200212D_10X-R4,666 cells BUKMAP_20200205A_10X-R3,730 cells KPMP_20191219D_10X-R3,695 cells BUKMAP_20200707B_10X-R3,473 cells KPMP_20190829E_10X-R3,199 cells KPMP_20200513B_10X-R3,190 cells KPMP_20190829D_10X-R3,056 cells BUKMAP_20190822F_10X-R2,962 cells KPMP_20200702B_10X-R2,891 cells BUKMAP_20200205F_10X-R2,468 cells BUKMAP_20190829B_10X-R2,444 cells BUKMAP_20191104A-10X-R2,256 cells KPMP_20200212F_10X-R2,098 cells BUKMAP_20200707A_10X-R2,013 cells BUKMAP_20200707C_10X-R1,678 cells KPMP_20190829C_10X-R1,661 cells KPMP_20200212G_10X-R1,301 cells BUKMAP_20200205D_10X-R1,291 cells KPMP_20200212A_10X-R1,256 cells KPMP_20191204B_10X-R352 cells BUKMAP_20191009-10X-R268 cells S-1910-000149_R113,763 cells S-1908-010077_R18,667 cells COV-02-0094-N18,609 cells S-1908-000858_R18,216 cells S-1909-007161_R17,019 cells S-1910-000196_R16,917 cells S-1908-009890_R16,099 cells S-1908-000952-R16,039 cells S-1908-009653_R15,380 cells S-1908-000905_R15,113 cells S-1908-009843_R14,799 cells S-1908-010125_R14,666 cells S-1910-000055_R13,695 cells COV-02-0096-N12,891 cells S-2001-000055_R12,098 cells Sample1153-EO31,334 cells Sample1162-EO21,329 cells S-2001-000102_R11,301 cells S-1908-010172_R11,256 cells Sample1157-EO21,166 cells Sample1157-EO11,042 cells S-1905-017562-R1352 cells Normal Reference107,701 cells Acute Kidney Injury (AKI)65,171 cells Diabetic Kidney Disease (DKD)64,429 cells Hypertensive CKD (H-CKD)39,860 cells Chronic Kidney Disease7,916 cells Sample1153-EO31,334 cells Sample1162-EO21,329 cells Sample1157-EO21,166 cells Sample1157-EO11,042 cells Deceased Donor19,246 cells Adaptive / Maladaptive / Repairing Proximal Tubule Epithelial Cell26,027 cells Degenerative Proximal Tubule Epithelial Cell25,023 cells Cortical Thick Ascending Limb Cell23,767 cells Proximal Tubule Epithelial Cell Segment 1 / Segment 217,623 cells Adaptive / Maladaptive / Repairing Thick Ascending Limb Cell14,924 cells Degenerative Medullary Thick Ascending Limb Cell11,109 cells Degenerative Outer Medullary Collecting Duct Principal Cell9,801 cells Peritubular Capilary Endothelial Cell9,195 cells Medullary Thick Ascending Limb Cell8,876 cells Distal Convoluted Tubule Cell Type 17,763 cells Cortical Collecting Duct Intercalated Cell Type A7,673 cells Connecting Tubule Cell7,024 cells Proximal Tubule Epithelial Cell Segment 36,549 cells Medullary Fibroblast6,138 cells Ascending Vasa Recta Endothelial Cell5,132 cells Descending Thin Limb Cell Type 14,700 cells Degenerative Distal Convoluted Tubule Cell4,551 cells Monocyte-derived Cell4,441 cells Cortical Collecting Duct Principal Cell4,361 cells Inner Medullary Collecting Duct Cell4,287 cells Descending Vasa Recta Endothelial Cell4,286 cells Natural Killer Cell / Natural Killer T Cell4,201 cells Macula Densa Cell4,115 cells Connecting Tubule Principal Cell3,975 cells Glomerular Capillary Endothelial Cell3,764 cells Degenerative Cortical Thick Ascending Limb Cell3,466 cells Vascular Smooth Muscle Cell / Pericyte3,449 cells Intercalated Cell Type B3,216 cells Degenerative Cortical Intercalated Cell Type A3,194 cells Descending Thin Limb Cell Type 23,130 cells Outer Medullary Collecting Duct Principal Cell2,897 cells Non-classical Monocyte2,435 cells Parietal Epithelial Cell2,417 cells Ascending Thin Limb Cell2,230 cells Degenerative Connecting Tubule Cell2,178 cells Degenerative Inner Medullary Collecting Duct Cell1,893 cells Outer Medullary Collecting Duct Intercalated Cell Type A1,845 cells Afferent / Efferent Arteriole Endothelial Cell1,705 cells Descending Thin Limb Cell Type 31,550 cells Adaptive / Maladaptive / Repairing Fibroblast1,516 cells Degenerative Vascular Smooth Muscle Cell1,461 cells Transitional Principal-Intercalated Cell1,409 cells Vascular Smooth Muscle Cell1,233 cells Degenerative Ascending Thin Limb Cell1,154 cells Distal Convoluted Tubule Cell Type 2827 cells Cycling Proximal Tubule Epithelial Cell809 cells Degenerative Medullary Fibroblast714 cells Connecting Tubule Intercalated Cell Type A664 cells Papillary Tip Epithelial Cell531 cells Degenerative Fibroblast469 cells Lymphatic Endothelial Cell463 cells Degenerative Podocyte412 cells Degenerative Descending Thin Limb Cell Type 3406 cells Degenerative Peritubular Capilary Endothelial Cell269 cells Degenerative Endothelial Cell236 cells Classical Dendritic Cell216 cells Cycling Mononuclear Phagocyte215 cells Cycling Natural Killer Cell / Natural Killer T Cell165 cells Cycling Endothelial Cell125 cells Renin-positive Juxtaglomerular Granular Cell106 cells Schwann Cell / Neural77 cells Plasmacytoid Dendritic Cell75 cells Cycling Distal Convoluted Tubule Cell75 cells Cycling Connecting Tubule Cell68 cells Cycling Myofibroblast66 cells adaptive - epi40,951 cells adaptive - str3,570 cells epithelial cells228,939 cells endothelial cells25,175 cells proximal tubules76,031 cells Distal tubules64,549 cells Collecting tubules55,016 cells intermediate tubules28,094 cells renal corpuscle9,471 cells 30.0 and Above30,398 cells 10x 3' v3, single-nucleus200,338 cells cortex of kidney122,914 cells renal medulla57,086 cells renal papilla20,338 cells African American55,974 cells Hispanic or Latin American8,609 cells 
2. Single-nucleus RNA-seq of the Adult Human Kidney (Version 1.0)
ExploreSample ID
Experiment
Specimen ID
Disease
Disease (level 1)
Disease (level 2)
Subject ID
Tissue region (level 1)
Tissue region (level 2)
Percent of cortex
Percent of medulla
Sample tissue type
Sample source
Cell type
Cell type (subclass l3)
Cell type (subclass l2)
Cell type (subclass l1)
State l2
State
Cell type (class)
Structure
eGFR
BMI
Diabetes history
Hypertension
Assay
Sex
Tissue
Ethnicity
Age
Age group
Leiden clustering
KPMP_20200115B_10X-R13,763 cells KPMP_20191219C_10X-R8,667 cells KPMP_20191219B_10X-R8,216 cells KPMP_20190607K-10X-R7,775 cells KPMP_20190607J-10X-R7,481 cells KPMP_20200115A_10X-R7,019 cells KPMP_20200212H_10X-R6,917 cells BUKMAP_20200304F_10X-R6,488 cells KPMP_20200212E_10X-R6,099 cells BUKMAP_20200702D_10X-R6,089 cells KPMP_20191204A_10X-R6,039 cells BUKMAP_20200304B_10X-R5,815 cells BUKMAP_20190529L_10X-R5,744 cells BUKMAP_20200304A_10X-R5,652 cells BUKMAP_20190607L_10X-R5,520 cells KPMP_20191219A_10X-R5,380 cells KPMP_20200212B_10X-R5,113 cells BUKMAP_20191010-10X-R4,837 cells KPMP_20200212C_10X-R4,799 cells KPMP_20190607I-10X-R4,765 cells BUKMAP_20200702C_10X-R4,718 cells KPMP_20200212D_10X-R4,666 cells BUKMAP_20200205A_10X-R3,730 cells KPMP_20191219D_10X-R3,695 cells BUKMAP_20200707B_10X-R3,473 cells BUKMAP_20190822F_10X-R2,962 cells BUKMAP_20200205F_10X-R2,468 cells BUKMAP_20190829B_10X-R2,444 cells BUKMAP_20191104A-10X-R2,256 cells KPMP_20200212F_10X-R2,098 cells BUKMAP_20200707A_10X-R2,013 cells BUKMAP_20200707C_10X-R1,678 cells KPMP_20200212G_10X-R1,301 cells BUKMAP_20200205D_10X-R1,291 cells KPMP_20200212A_10X-R1,256 cells KPMP_20191204B_10X-R352 cells BUKMAP_20191009-10X-R268 cells S-1910-000149_R113,763 cells S-1908-010077_R18,667 cells S-1908-000858_R18,216 cells S-1909-007161_R17,019 cells S-1910-000196_R16,917 cells S-1908-009890_R16,099 cells S-1908-000952-R16,039 cells S-1908-009653_R15,380 cells S-1908-000905_R15,113 cells S-1908-009843_R14,799 cells S-1908-010125_R14,666 cells S-1910-000055_R13,695 cells S-2001-000055_R12,098 cells S-2001-000102_R11,301 cells S-1908-010172_R11,256 cells S-1905-017562-R1352 cells Normal Reference87,467 cells Acute Kidney Injury (AKI)30,867 cells Hypertensive CKD (H-CKD)30,787 cells Diabetic Kidney Disease (DKD)23,726 cells Deceased Donor19,246 cells Degenerative Proximal Tubule Epithelial Cell16,300 cells Adaptive / Maladaptive / Repairing Proximal Tubule Epithelial Cell13,339 cells Degenerative Medullary Thick Ascending Limb Cell10,196 cells Proximal Tubule Epithelial Cell Segment 1 / Segment 28,929 cells Medullary Thick Ascending Limb Cell8,124 cells Cortical Thick Ascending Limb Cell8,085 cells Adaptive / Maladaptive / Repairing Thick Ascending Limb Cell6,012 cells Medullary Fibroblast5,960 cells Distal Convoluted Tubule Cell Type 15,940 cells Peritubular Capilary Endothelial Cell5,273 cells Proximal Tubule Epithelial Cell Segment 34,700 cells Inner Medullary Collecting Duct Cell4,129 cells Cortical Collecting Duct Intercalated Cell Type A3,984 cells Ascending Vasa Recta Endothelial Cell3,876 cells Connecting Tubule Cell3,673 cells Descending Vasa Recta Endothelial Cell3,308 cells Descending Thin Limb Cell Type 13,220 cells Degenerative Outer Medullary Collecting Duct Principal Cell3,218 cells Cortical Collecting Duct Principal Cell3,028 cells Outer Medullary Collecting Duct Principal Cell2,653 cells Descending Thin Limb Cell Type 22,382 cells Vascular Smooth Muscle Cell / Pericyte1,926 cells Glomerular Capillary Endothelial Cell1,834 cells Degenerative Inner Medullary Collecting Duct Cell1,821 cells Ascending Thin Limb Cell1,799 cells Macula Densa Cell1,652 cells Connecting Tubule Principal Cell1,649 cells Outer Medullary Collecting Duct Intercalated Cell Type A1,622 cells Monocyte-derived Cell1,604 cells Intercalated Cell Type B1,501 cells Descending Thin Limb Cell Type 31,483 cells Adaptive / Maladaptive / Repairing Fibroblast1,456 cells Degenerative Cortical Thick Ascending Limb Cell1,355 cells Parietal Epithelial Cell1,150 cells Degenerative Ascending Thin Limb Cell1,142 cells Vascular Smooth Muscle Cell1,026 cells Degenerative Medullary Fibroblast708 cells Afferent / Efferent Arteriole Endothelial Cell672 cells Degenerative Cortical Intercalated Cell Type A654 cells Distal Convoluted Tubule Cell Type 2516 cells Degenerative Connecting Tubule Cell507 cells Natural Killer Cell / Natural Killer T Cell440 cells Non-classical Monocyte419 cells Transitional Principal-Intercalated Cell411 cells Degenerative Descending Thin Limb Cell Type 3406 cells Cycling Proximal Tubule Epithelial Cell357 cells Papillary Tip Epithelial Cell326 cells Lymphatic Endothelial Cell292 cells Degenerative Peritubular Capilary Endothelial Cell252 cells Connecting Tubule Intercalated Cell Type A230 cells Degenerative Vascular Smooth Muscle Cell210 cells Degenerative Fibroblast203 cells Degenerative Podocyte194 cells Degenerative Endothelial Cell179 cells Degenerative Distal Convoluted Tubule Cell154 cells Classical Dendritic Cell143 cells Cycling Mononuclear Phagocyte108 cells Cycling Endothelial Cell93 cells Cycling Distal Convoluted Tubule Cell68 cells Cycling Myofibroblast64 cells Schwann Cell / Neural59 cells Renin-positive Juxtaglomerular Granular Cell55 cells Cycling Connecting Tubule Cell54 cells Plasmacytoid Dendritic Cell53 cells adaptive - epi19,351 cells adaptive - str3,378 cells epithelial cells128,888 cells endothelial cells15,779 cells proximal tubules43,625 cells Distal tubules36,090 cells Collecting tubules29,460 cells intermediate tubules16,444 cells renal corpuscle5,455 cells 30.0 and Above23,076 cells 10x 3' v3, single-nucleus172,847 cells cortex of kidney97,084 cells renal medulla55,425 cells renal papilla20,338 cells African American14,849 cells 
3. Single-cell RNA-seq of the Adult Human Kidney (Version 1.0)
ExploreTissue region (level 2)
Tissue region (level 1)
Data source
Sample type
Clustering
Tissue type
Cell type (subclass)
eGFR
BMI
Diabetes history
Hypertension
Specimen ID
Subject ID
Sex
Ethnicity
Age
Sample ID
Experiment
Disease
Disease (level 1)
Disease (level 2)
Percent of cortex
Percent of medulla
Sample tissue type
Sample source
Cell type
Cell type (subclass l3)
Cell type (subclass l2)
Cell type (subclass l1)
State l2
State
Cell type (class)
Structure
Assay
Tissue
Age group
Leiden clustering
disease biopsy86,847 cells 30.0 and Above4,361 cells Sample1162-EO21,345 cells Sample1153-EO31,338 cells Sample1157-EO21,204 cells Sample1157-EO11,045 cells Sample1162-EO21,345 cells Sample1153-EO31,338 cells Sample1157-EO21,204 cells Sample1157-EO11,045 cells African American30,907 cells Diabetic Kidney Disease (DKD)40,703 cells Acute Kidney Injury (AKI)34,991 cells Normal Reference20,497 cells Hypertensive CKD (H-CKD)11,153 cells Cortical Thick Ascending Limb Cell13,849 cells Adaptive / Maladaptive / Repairing Proximal Tubule Epithelial Cell10,315 cells Degenerative Proximal Tubule Epithelial Cell6,879 cells Degenerative Outer Medullary Collecting Duct Principal Cell6,299 cells Proximal Tubule Epithelial Cell Segment 1 / Segment 25,933 cells Adaptive / Maladaptive / Repairing Thick Ascending Limb Cell5,486 cells Degenerative Distal Convoluted Tubule Cell4,356 cells Natural Killer Cell / Natural Killer T Cell3,644 cells Peritubular Capilary Endothelial Cell3,164 cells Cortical Collecting Duct Intercalated Cell Type A2,835 cells Connecting Tubule Cell2,637 cells Monocyte-derived Cell2,521 cells Degenerative Cortical Intercalated Cell Type A2,382 cells Macula Densa Cell2,051 cells Connecting Tubule Principal Cell2,021 cells Non-classical Monocyte1,839 cells Degenerative Connecting Tubule Cell1,623 cells Glomerular Capillary Endothelial Cell1,490 cells Vascular Smooth Muscle Cell / Pericyte1,416 cells Intercalated Cell Type B1,274 cells Degenerative Vascular Smooth Muscle Cell1,247 cells Descending Thin Limb Cell Type 11,206 cells Ascending Vasa Recta Endothelial Cell1,091 cells Parietal Epithelial Cell992 cells Transitional Principal-Intercalated Cell979 cells Afferent / Efferent Arteriole Endothelial Cell961 cells Descending Vasa Recta Endothelial Cell830 cells Proximal Tubule Epithelial Cell Segment 3809 cells Cortical Collecting Duct Principal Cell610 cells Descending Thin Limb Cell Type 2557 cells Medullary Thick Ascending Limb Cell511 cells Degenerative Cortical Thick Ascending Limb Cell493 cells Distal Convoluted Tubule Cell Type 1452 cells Ascending Thin Limb Cell427 cells Cycling Proximal Tubule Epithelial Cell423 cells Connecting Tubule Intercalated Cell Type A410 cells Degenerative Medullary Thick Ascending Limb Cell328 cells Distal Convoluted Tubule Cell Type 2248 cells Degenerative Fibroblast217 cells Outer Medullary Collecting Duct Intercalated Cell Type A209 cells Outer Medullary Collecting Duct Principal Cell203 cells Papillary Tip Epithelial Cell202 cells Degenerative Podocyte185 cells Cycling Natural Killer Cell / Natural Killer T Cell165 cells Inner Medullary Collecting Duct Cell139 cells Lymphatic Endothelial Cell113 cells Vascular Smooth Muscle Cell87 cells Cycling Mononuclear Phagocyte76 cells Descending Thin Limb Cell Type 355 cells Adaptive / Maladaptive / Repairing Fibroblast48 cells Renin-positive Juxtaglomerular Granular Cell45 cells Classical Dendritic Cell31 cells Cycling Endothelial Cell20 cells Degenerative Endothelial Cell11 cells Medullary Fibroblast6 cells Schwann Cell / Neural5 cells adaptive - epi15,801 cells epithelial cells80,489 cells endothelial cells7,682 cells proximal tubules24,359 cells Distal tubules22,288 cells Collecting tubules21,823 cells intermediate tubules7,731 cells renal corpuscle2,823 cells 
4. Patient 20-576 [Slide-seq2]
ExploreCell type
Cell type (level 2)
Sample ID
Leiden clustering
Subject ID
Specimen ID
Assay
Disease
Tissue annotation (level 1)
Tissue annotation (level 2)
Sex
Tissue type
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GSM6128252_Puck_201229_0726,724 cells GSM6128255_Puck_201229_1124,056 cells GSM6128254_Puck_201229_1023,944 cells GSM6128253_Puck_201229_0821,569 cells GSM6128248_Puck_201229_0313,586 cells GSM6128250_Puck_201229_0511,347 cells GSM6128251_Puck_201229_0611,300 cells GSM6128249_Puck_201229_0410,331 cells GSM6128247_Puck_201229_0210,267 cells GSM6128256_Puck_201229_129,824 cells GSM6128246_Puck_201229_014,155 cells Patient 20-576167,103 cells Puck_201229_0726,724 cells Puck_201229_1124,056 cells Puck_201229_1023,944 cells Puck_201229_0821,569 cells Puck_201229_0313,586 cells Puck_201229_0511,347 cells Puck_201229_0611,300 cells Puck_201229_0410,331 cells Puck_201229_0210,267 cells Puck_201229_129,824 cells Puck_201229_014,155 cells Normal reference167,103 cells Outer Medulla106,117 cells 
5. Patient 21-019 [Slide-seq2]
ExploreCell type
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Sample ID
Leiden clustering
Specimen ID
Assay
Disease
Subject ID
Tissue annotation level 1
Tissue annotation level 2
Sex
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GEO accession
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GSM6128259_Puck_210412_0325,988 cells GSM6128260_Puck_210412_0425,093 cells GSM6128262_Puck_210412_0824,858 cells GSM6128257_Puck_210412_0122,660 cells GSM6128258_Puck_210412_0221,687 cells GSM6128261_Puck_210412_0720,080 cells GSM6128263_Puck_210412_0918,280 cells GSM6128264_Puck_210412_1017,357 cells GSM6128266_Puck_210412_1316,894 cells GSM6128267_Puck_210412_1616,799 cells GSM6128265_Puck_210412_1113,179 cells Puck_210412_0325,988 cells Puck_210412_0425,093 cells Puck_210412_0824,858 cells Puck_210412_0122,660 cells Puck_210412_0221,687 cells Puck_210412_0720,080 cells Puck_210412_0918,280 cells Puck_210412_1017,357 cells Puck_210412_1316,894 cells Puck_210412_1616,799 cells Puck_210412_1113,179 cells Normal reference222,875 cells Outer Medulla140,366 cells 
6. Patient 21-020 [Slide-seq2]
ExploreCell type
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Sample ID
Leiden clustering
Specimen ID
Assay
Subject ID
Tissue annotation level 1
Tissue annotation level 2
Sex
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GEO accession
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GSM6128278_Puck_210412_2928,181 cells GSM6128277_Puck_210412_2725,382 cells GSM6128275_Puck_210412_2420,015 cells GSM6128274_Puck_210412_2319,067 cells GSM6128279_Puck_210412_3118,849 cells GSM6128268_Puck_210412_1718,620 cells GSM6128271_Puck_210412_2018,077 cells GSM6128272_Puck_210412_2117,765 cells GSM6128276_Puck_210412_2617,197 cells GSM6128269_Puck_210412_1816,593 cells GSM6128270_Puck_210412_1916,440 cells GSM6128273_Puck_210412_2211,478 cells Puck_210412_2928,181 cells Puck_210412_2725,382 cells Puck_210412_2420,015 cells Puck_210412_2319,067 cells Puck_210412_3118,849 cells Puck_210412_1718,620 cells Puck_210412_2018,077 cells Puck_210412_2117,765 cells Puck_210412_2617,197 cells Puck_210412_1816,593 cells Puck_210412_1916,440 cells Puck_210412_2211,478 cells Cortex / Medulla25,382 cells Outer Medulla86,112 cells Normal reference227,664 cells 
7. Patient 3579 [Slide-seq2]
ExploreCell type
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Sample ID
Leiden clustering
Specimen ID
Assay
Subject ID
Tissue annotation level 1
Tissue annotation level 2
Sex
Race
Tissue type
Sample source
Source ID
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GSM5554452_Puck_200903_0630,275 cells GSM5554456_Puck_200906_1027,322 cells GSM5554451_Puck_200903_0525,465 cells GSM5554454_Puck_200903_2525,459 cells GSM5554457_Puck_200906_1825,366 cells GSM5554453_Puck_200903_0724,701 cells GSM5554450_Puck_200903_0324,065 cells GSM5554455_Puck_200903_2622,410 cells GSM5554448_Puck_200903_0120,828 cells GSM5554449_Puck_200903_0220,222 cells Puck_200903_0630,275 cells Puck_200906_1027,322 cells Puck_200903_0525,465 cells Puck_200903_2525,459 cells Puck_200906_1825,366 cells Puck_200903_0724,701 cells Puck_200903_0324,065 cells Puck_200903_2622,410 cells Puck_200903_0120,828 cells Puck_200903_0220,222 cells Patient 3579246,113 cells HBM336.GKJN.63930,275 cells HBM537.VLPL.73427,322 cells HBM364.JRNL.42225,465 cells HBM427.RVVD.27625,459 cells HBM786.LZQZ.24225,366 cells HBM247.GGHT.65824,701 cells HBM488.GXLS.68924,065 cells HBM464.KHSK.92722,410 cells HBM346.CSWK.38820,828 cells HBM956.NKKJ.64620,222 cells Normal reference246,113 cells 
8. Patient 3593 [Slide-seq2]
ExploreCell type
Cell type (level 2)
Sample ID
Leiden clustering
Specimen ID
Assay
Subject ID
Tissue annotation level 1
Tissue annotation level 2
Sex
Race
Donor living at sample collection
Sample source
Source ID
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Tissue
Disease
GSM6128228_Puck_210113_2631,645 cells GSM6128223_Puck_210113_2130,113 cells GSM6128225_Puck_210113_2327,437 cells GSM6128230_Puck_210113_2826,936 cells GSM6128243_Puck_210119_0926,072 cells GSM6128226_Puck_210113_2425,903 cells GSM6128231_Puck_210113_2925,552 cells GSM6128229_Puck_210113_2724,802 cells GSM6128224_Puck_210113_2222,247 cells GSM6128232_Puck_210113_3021,369 cells GSM6128227_Puck_210113_2518,167 cells Puck_210113_2631,645 cells Puck_210113_2130,113 cells Puck_210113_2327,437 cells Puck_210113_2826,936 cells Puck_210119_0926,072 cells Puck_210113_2425,903 cells Puck_210113_2925,552 cells Puck_210113_2724,802 cells Puck_210113_2222,247 cells Puck_210113_3021,369 cells Puck_210113_2518,167 cells Patient 3593280,243 cells Outer Medulla136,244 cells Inner Medulla117,927 cells Deceased Donor280,243 cells HBM499.GPFC.89431,645 cells HBM472.ZSRG.58630,113 cells HBM876.NMKV.39227,437 cells HBM684.XVPK.33626,936 cells HBM387.KXLD.86726,072 cells HBM246.PZPG.57325,903 cells HBM543.DWSW.97825,552 cells HBM832.WWZH.57524,802 cells HBM969.VBPS.23922,247 cells HBM337.GJHZ.66521,369 cells HBM757.CMSL.89718,167 cells Normal reference280,243 cells 
9. Patient 3611 [Slide-seq2]
ExploreCell type
Cell type (level 2)
Sample ID
Leiden clustering
Specimen ID
Assay
Subject ID
Tissue annotation level 1
Tissue annotation level 2
Sex
Race
Tissue type
Sample source
Source ID
Reference genome
Age group
Tissue
Disease
GSM6128236_Puck_210113_3437,110 cells GSM6128241_Puck_210113_3934,758 cells GSM6128233_Puck_210113_3134,723 cells GSM6128239_Puck_210113_3734,440 cells GSM6128235_Puck_210113_3331,966 cells GSM6128237_Puck_210113_3531,610 cells GSM6128234_Puck_210113_3231,421 cells GSM6128240_Puck_210113_3826,541 cells GSM6128238_Puck_210113_3622,589 cells GSM6128242_Puck_210113_4014,188 cells GSM6128244_Puck_210119_1810,549 cells GSM6128245_Puck_210119_207,691 cells Puck_210113_3437,110 cells Puck_210113_3934,758 cells Puck_210113_3134,723 cells Puck_210113_3734,440 cells Puck_210113_3331,966 cells Puck_210113_3531,610 cells Puck_210113_3231,421 cells Puck_210113_3826,541 cells Puck_210113_3622,589 cells Puck_210113_4014,188 cells Puck_210119_1810,549 cells Puck_210119_207,691 cells Patient 3611317,586 cells Outer Medulla299,346 cells HBM348.FXGT.72837,110 cells HBM492.QPNN.57934,758 cells HBM797.HSMJ.59634,723 cells HBM272.KQDJ.87334,440 cells HBM754.SJMP.48631,966 cells HBM778.VKRZ.93431,610 cells HBM699.CHMK.45731,421 cells HBM489.LPCX.97826,541 cells HBM586.QXWD.49222,589 cells HBM258.RBCM.39314,188 cells HBM838.LDFP.57810,549 cells HBM973.XRLR.3657,691 cells Normal reference317,586 cells 
10. Spatial localization with Spatial Transcriptomics for an atlas of healthy and injured cell states and niches in the human kidney [Visium ST]
ExploreSample ID
Specimen ID
Assay
Disease
Disease (level 1)
Disease (level 2)
Subject ID
Tissue annotation
Sex
Race
Tissue type
Sample source
Source ID
Tissue
Reference genome
Sample preservation method
Leiden clustering
eGFR
Age group
Age
BMI
V19S25-019_XY03-M614,166 cells V19S25-019_XY04-F523,627 cells V19S25-019_XY02-M322,627 cells V19S25-017_XY03-134371,322 cells V10S15-102_XY02_IU-21-019-51,034 cells V10S15-102_XY03_IU-21-015-2956 cells V10S14-086_XY03_21-0063904 cells V10S14-086_XY01_21-0055787 cells V10S14-085_XY03_21-0056673 cells V10S21-388_XY04_20-0073673 cells V10S21-388_XY03_20-0072673 cells V10S14-085_XY02_20-0040645 cells V10S14-086_XY04_21-0066640 cells V10S14-086_XY02_20-0039601 cells V10S21-388_XY01_21-0068560 cells V10S14-087_XY03_21-0064534 cells V10S14-087_XY04_21-0065507 cells V10S14-087_XY02_21-0063461 cells V10S14-087_XY01_21-0061453 cells V10S14-085_XY04_21-0057407 cells V10S21-388_XY02_20-0071370 cells V10S14-085_XY01_20-0038317 cells Diabetic Kidney Disease (DKD)6,053 cells Acute Kidney Injury (AKI)3,152 cells Chronic Kidney Injury (CKD)1,322 cells Cortex / Medulla2,263 cells 
11. An atlas of healthy and injured cell states and niches in the human kidney [SNARE-Seq2]
ExploreLibrary ID
Doublet detection
Sample ID
Experiment
Specimen ID
Disease
Subject ID
Tissue region (level 1)
Tissue region (level 2)
Tissue region (level 3)
Sex
Race
Tissue type
Assay
Sample source
Cell type (predicted class)
Cell type (predicted subclass l1)
Cell type
Cell type (subclass l3)
Cell type (subclass l2)
Cell type (subclass l1)
State (level 2)
State (level 1)
Cell type (class)
Structure
Tissue
Leiden clustering
Sample preservation method
Reference genome
Age group
BUKMAP_20190822E_SNARE2-R9,338 cells BUKMAP_20190822C_SNARE2-R8,309 cells BUKMAP_20190529F_SNARE2-R6,960 cells BUKMAP_20190822B_SNARE2-R6,419 cells BUKMAP_20190529G_SNARE2-R4,624 cells BUKMAP_20190822D_SNARE2-R3,192 cells BUKMAP_20200211B_SNARE2-R_P192,928 cells BUKMAP_20200211H_SNARE2-R_P82,656 cells BUKMAP_20200211E_SNARE2-R_P82,610 cells BUKMAP_20200211B_SNARE2-R_P152,325 cells BUKMAP_20200211B_SNARE2-R_P162,267 cells BUKMAP_20200211H_SNARE2-R_P32,182 cells BUKMAP_20200211B_SNARE2-R_P172,180 cells BUKMAP_20200211H_SNARE2-R_P22,111 cells BUKMAP_20200211H_SNARE2-R_P42,090 cells BUKMAP_20200211B_SNARE2-R_P132,079 cells BUKMAP_20200211B_SNARE2-R_P142,059 cells BUKMAP_20200211H_SNARE2-R_P12,057 cells BUKMAP_20200211E_SNARE2-R_P42,027 cells BUKMAP_20200211E_SNARE2-R_P12,023 cells BUKMAP_20200211E_SNARE2-R_P21,999 cells BUKMAP_20200211E_SNARE2-R_P31,983 cells BUKMAP_20200211E_SNARE2-R_P51,980 cells BUKMAP_20200211H_SNARE2-R_P71,949 cells BUKMAP_20200211H_SNARE2-R_P51,949 cells BUKMAP_20200211H_SNARE2-R_P61,852 cells BUKMAP_20200211E_SNARE2-R_P71,794 cells BUKMAP_20200211E_SNARE2-R_P61,741 cells BUKMAP_20190822A_SNARE2-R1,149 cells BUKMAP_20200211C_SNARE2-R_P19948 cells BUKMAP_20200211A_SNARE2-R_P19864 cells BUKMAP_20190529E_SNARE2-R833 cells BUKMAP_20200211C_SNARE2-R_P17753 cells BUKMAP_20200211C_SNARE2-R_P15737 cells BUKMAP_20200211C_SNARE2-R_P16720 cells BUKMAP_20200211C_SNARE2-R_P13699 cells BUKMAP_20200211C_SNARE2-R_P14659 cells BUKMAP_20200211A_SNARE2-R_P13658 cells BUKMAP_20200211A_SNARE2-R_P17636 cells BUKMAP_20200211A_SNARE2-R_P15632 cells BUKMAP_20200211F_SNARE2-R_P8626 cells BUKMAP_20200211A_SNARE2-R_P16608 cells BUKMAP_20200211A_SNARE2-R_P14600 cells BUKMAP_20200211F_SNARE2-R_P2538 cells BUKMAP_20200211F_SNARE2-R_P3535 cells BUKMAP_20200211F_SNARE2-R_P4511 cells BUKMAP_20200211F_SNARE2-R_P5508 cells BUKMAP_20200211D_SNARE2-R_P19504 cells BUKMAP_20200211F_SNARE2-R_P1482 cells BUKMAP_20200211F_SNARE2-R_P7479 cells BUKMAP_20200211F_SNARE2-R_P6452 cells BUKMAP_20200211D_SNARE2-R_P16430 cells BUKMAP_20200211D_SNARE2-R_P17422 cells BUKMAP_20200211D_SNARE2-R_P15407 cells BUKMAP_20200211D_SNARE2-R_P14373 cells BUKMAP_20200211D_SNARE2-R_P13367 cells BUKMAP_20200211G_SNARE2-R_P19365 cells BUKMAP_20200211G_SNARE2-R_P17290 cells BUKMAP_20200211G_SNARE2-R_P16274 cells BUKMAP_20190529D_SNARE2-R261 cells BUKMAP_20200211G_SNARE2-R_P14243 cells BUKMAP_20200211G_SNARE2-R_P15241 cells BUKMAP_20200211G_SNARE2-R_P13235 cells BUKMAP_20200211B_SNARE2-R_P1851 cells BUKMAP_20200211D_SNARE2-R_P1816 cells BUKMAP_20200211G_SNARE2-R_P189 cells BUKMAP_20200211C_SNARE2-R_P187 cells BUKMAP_20200211A_SNARE2-R_P184 cells BUKMAP_20200211H16,846 cells BUKMAP_20200211E16,157 cells BUKMAP_20200211B13,889 cells BUKMAP_20190822E9,338 cells BUKMAP_20190822C8,309 cells BUKMAP_20190529F6,960 cells BUKMAP_20190822B6,419 cells BUKMAP_20190529G4,624 cells BUKMAP_20200211C4,523 cells BUKMAP_20200211F4,131 cells BUKMAP_20200211A4,002 cells BUKMAP_20190822D3,192 cells BUKMAP_20200211D2,519 cells BUKMAP_20200211G1,657 cells BUKMAP_20190822A1,149 cells BUKMAP_20190529E833 cells BUKMAP_20190529D261 cells Normal Reference104,809 cells Deceased Donor67,346 cells epithelial cells91,578 cells endothelial cells4,693 cells Medullary Thick Ascending Limb Cell15,987 cells Adaptive / Maladaptive / Repairing Proximal Tubule Epithelial Cell9,083 cells Proximal Tubule Epithelial Cell Segment 18,731 cells Adaptive / Maladaptive / Repairing Thick Ascending Limb Cell7,546 cells Degenerative Outer Medullary Collecting Duct Principal Cell5,579 cells Cortical Thick Ascending Limb Cell4,811 cells Descending Thin Limb Cell Type 14,697 cells Medullary Fibroblast3,476 cells Cortical Collecting Duct Intercalated Cell Type A3,295 cells Degenerative Medullary Thick Ascending Limb Cell3,227 cells Distal Convoluted Tubule Cell Type 12,711 cells Descending Thin Limb Cell Type 22,709 cells Cortical Collecting Duct Principal Cell2,664 cells Proximal Tubule Epithelial Cell Segment 32,516 cells Proximal Tubule Epithelial Cell Segment 22,360 cells Connecting Tubule Cell2,174 cells Outer Medullary Collecting Duct Intercalated Cell Type A1,822 cells Ascending Vasa Recta Endothelial Cell1,660 cells Descending Vasa Recta Endothelial Cell1,349 cells Ascending Thin Limb Cell1,269 cells Peritubular Capilary Endothelial Cell1,230 cells Outer Medullary Collecting Duct Principal Cell1,118 cells Degenerative Proximal Tubule Epithelial Cell991 cells Vascular Smooth Muscle Cell / Pericyte989 cells Transitional Principal-Intercalated Cell727 cells Connecting Tubule Principal Cell663 cells Degenerative Cortical Intercalated Cell Type A647 cells Degenerative Cortical Thick Ascending Limb Cell604 cells Parietal Epithelial Cell478 cells Macula Densa Cell472 cells Intercalated Cell Type B470 cells Monocyte-derived Cell390 cells Glomerular Capillary Endothelial Cell375 cells Cycling Proximal Tubule Epithelial Cell360 cells Inner Medullary Collecting Duct Cell287 cells Distal Convoluted Tubule Cell Type 2268 cells Connecting Tubule Intercalated Cell Type A227 cells Degenerative Inner Medullary Collecting Duct Cell190 cells Degenerative Peritubular Capilary Endothelial Cell170 cells Adaptive / Maladaptive / Repairing Fibroblast165 cells Vascular Smooth Muscle Cell146 cells Degenerative Connecting Tubule Cell122 cells Degenerative Fibroblast109 cells Lymphatic Endothelial Cell89 cells Natural Killer T Cell79 cells Non-Classical Monocyte77 cells Renin-positive Juxtaglomerular Granular Cell24 cells Afferent / Efferent Arteriole Endothelial Cell18 cells adaptive - epi16,629 cells epithelial cells90,817 cells endothelial cells4,891 cells distal tubules28,080 cells proximal tubules24,041 cells collecting tubules19,985 cells intermediate tubules16,221 cells renal corpuscle2,940 cells cryosectioned104,809 cells 
Alias names
GSE183279, GSE183273, GSE183274, GSE183276, GSE183277, GSE183456, GSE199711